Page 48 - AN-4-4
P. 48

Advanced Neurology                                                  Lipid metabolism and Parkinson’s disease



               doi: 10.1038/s41583-025-00908-3                 41.  Wang L, He M, Liu X, Jiang BP, Chen H, Shen XC. Dual-
                                                                  labeled single fluorescent probes for the simultaneous two-
            31.  Castellanos DB, Martín-Jiménez CA, Rojas-Rodríguez  F,
               Barreto GE, González J. Brain lipidomics as a rising   color visualization of dual organelles and for monitoring cell
               field in neurodegenerative contexts: Perspectives with   autophagy. Anal Chem. 2024;96(2):876-886.
               machine learning approaches.  Front Neuroendocrinol.      doi: 10.1021/acs.analchem.3c04520
               2021;61:100899.
                                                               42.  Herker E, Vieyres G, Beller M, Krahmer N, Bohnert M.
               doi: 10.1016/j.yfrne.2021.100899                   Lipid droplet contact sites in health and disease. Trends Cell
                                                                  Biol. 2021;31(5):345-358.
            32.  Tian J, Zhang Y, Zhao X. The effects and mechanisms of n-3
               and n-6 polyunsaturated fatty acids in the central nervous      doi: 10.1016/j.tcb.2021.01.004
               system. Cell Mol Neurobiol. 2025;45(1):25.
                                                               43.  Zhang Y, Chen Y, Zhuang C, Qi J, Zhao RC, Wang J. Lipid
               doi: 10.1007/s10571-025-01543-3                    droplets in the nervous system: Involvement in cell metabolic
                                                                  homeostasis. Neural Regen Res. 2025;20(3):740-750.
            33.  Fanning S, Haque A, Imberdis T, et al. Lipidomic analysis
               of  α-synuclein neurotoxicity identifies stearoyl CoA      doi: 10.4103/NRR.NRR-D-23-01401
               desaturase as a target for Parkinson treatment.  Molecular   44.  Kumar M, Wu Y, Knapp J,  et al. Triglycerides are an
               Cell. 2019;73(5):1001-1014.e8.
                                                                  important fuel reserve for synapse function in the brain. Nat
               doi: 10.1016/j.molcel.2018.11.028                  Metab. 2025;7(7):1392-1403.
            34.  Nettebrock NT, Bohnert M. Born this way - biogenesis of      doi: 10.1038/s42255-025-01321-x
               lipid droplets from specialized ER subdomains.  Biochim   45.  Shatz N, Chohan Y, Klionsky DJ. ATG14 and STX18:
               Biophys Acta Mol Cell Biol Lipids. 2020;1865(1):158448.
                                                                  Gatekeepers of lipid droplet degradation and the implications
               doi: 10.1016/j.bbalip.2019.04.008                  for disease modulation. Autophagy. 2024;20(8):1697-1699.
            35.  Benador IY, Veliova M, Mahdaviani K, et al. Mitochondria      doi: 10.1080/15548627.2024.2350739
               bound to lipid droplets have unique bioenergetics,   46.  Bouchaoui H, Mahoney-Sanchez L, Garçon G, et al. ACSL4
               composition, and dynamics that support lipid droplet   and the lipoxygenases 15/15B are pivotal for ferroptosis
               expansion. Cell Metab. 2018;27(4):869-885.e6.
                                                                  induced by iron and PUFA dyshomeostasis in dopaminergic
               doi: 10.1016/j.cmet.2018.03.003                    neurons. Free Radic Biol Med. 2023;195:145-157.
            36.  Rambold AS, Cohen S, Lippincott-Schwartz J. Fatty acid      doi: 10.1016/j.freeradbiomed.2022.12.086
               trafficking in starved cells: Regulation by lipid droplet   47.  Bickel PE, Tansey JT, Welte MA. PAT proteins, an ancient
               lipolysis, autophagy, and mitochondrial fusion dynamics.   family of lipid droplet proteins that regulate cellular lipid
               Dev Cell. 2015;32(6):678-692.
                                                                  stores. Biochim Biophys Acta. 2009;1791(6):419-440.
               doi: 10.1016/j.devcel.2015.01.029
                                                                  doi: 10.1016/j.bbalip.2009.04.002
            37.  Bulankina AV, Deggerich A, Wenzel D,  et al. TIP47   48.  Girard V, Jollivet F, Knittelfelder O,  et al. Abnormal
               functions in the biogenesis of lipid droplets.  J  Cell Biol.   accumulation of lipid droplets  in neurons induces the
               2009;185(4):641-655.
                                                                  conversion of alpha-synuclein to proteolytic resistant forms
               doi: 10.1083/jcb.200812042                         in a Drosophila model of Parkinson’s disease. PLOS Genet.
                                                                  2021;17(11):e1009921.
            38.  Bezawork-Geleta A, Devereux CJ, Keenan SN, et al. Proximity
               proteomics reveals a mechanism of fatty acid transfer at lipid      doi: 10.1371/journal.pgen.1009921
               droplet-mitochondria-endoplasmic reticulum contact sites.   49.  Han X, Liu Y, Dai Y,  et al. Neuronal SH2B1 attenuates
               Nat Commun. 2025;16(1):2135.
                                                                  apoptosis in an MPTP mouse model of Parkinson’s
               doi: 10.1038/s41467-025-57405-5                    disease via promoting PLIN4 degradation.  Redox  Biol.
                                                                  2022;52:102308.
            39.  Hong Z, Adlakha J, Wan N, et al. Mitoguardin-2-mediated
               lipid transfer preserves mitochondrial morphology and lipid      doi: 10.1016/j.redox.2022.102308
               droplet formation. J Cell Biol. 2022;221(12):e202207022.
                                                               50.  Han X, Zhu J, Zhang X, et al. Plin4-dependent lipid droplets
               doi: 10.1083/jcb.202207022                         hamper neuronal mitophagy in the MPTP/p-induced mouse
                                                                  model of Parkinson’s disease. Front Neurosci. 2018;12:397.
            40.  Vrijsen S, Vrancx C, Del Vecchio M, et al. Inter-organellar
               communication in Parkinson’s and Alzheimer’s disease:      doi: 10.3389/fnins.2018.00397
               Looking  beyond  endoplasmic  reticulum-mitochondria   51.  Costa CAD, Manaa WE, Duplan E, Checler F. The
               contact sites. Front Neurosci. 2022;16:900338.
                                                                  endoplasmic reticulum stress/unfolded protein response and
               doi: 10.3389/fnins.2022.900338                     their contributions to Parkinson’s disease physiopathology.


            Volume 4 Issue 4 (2025)                         42                           doi: 10.36922/AN025320086
   43   44   45   46   47   48   49   50   51   52   53