Page 50 - AN-4-4

Advanced Neurology Lipid metabolism and Parkinson’s disease

Chen QH. Gut microbiota and short chain fatty acids: through GPR109A modulation and intestinal barrier
Influence on the autonomic nervous system. Neurosci Bull. restoration on PD mice. Nutrients. 2022;14(19):4163.
2020;36(1):91-95.
doi: 10.3390/nu14194163
doi: 10.1007/s12264-019-00410-8
84. Song C, Zhang J, Qi S, et al. Cardiolipin remodeling by
74. Duan WX, Wang F, Liu JY, Liu CF. Relationship between ALCAT1 links mitochondrial dysfunction to Parkinson’s
short-chain fatty acids and Parkinson’s disease: A review diseases. Aging Cell. 2019;18(3):e12941.
from pathology to clinic. Neurosci Bull. 2024;40(4):500-516.
doi: 10.1111/acel.12941
doi: 10.1007/s12264-023-01123-9
85. Rua AJ, Mitchell W, Claypool SM, Alder NN, Alexandrescu AT.
75. Cao Q, Shen M, Li R, et al. Elucidating the specific mechanisms Perturbations in mitochondrial metabolism associated with
of the gut-brain axis: The short-chain fatty acids-microglia defective cardiolipin biosynthesis: An in-organello real-time
pathway. J Neuroinflammation. 2025;22(1):133. NMR study. J Biol Chem. 2024;300(10):107746.
doi: 10.1186/s12974-025-03454-y doi: 10.1016/j.jbc.2024.107746
76. Chen SJ, Chen CC, Liao HY, et al. Association of fecal and 86. Tang Y, Wu J, Sun X, et al. Cardiolipin oxidized by ROS
plasma levels of short-chain fatty acids with gut microbiota from complex II acts as a target of gasdermin D to drive
and clinical severity in patients with Parkinson disease. mitochondrial pore and heart dysfunction in endotoxemia.
Neurology. 2022;98(8):e848-e858. Cell Rep. 2024;43(5):114237.
doi: 10.1212/WNL.0000000000013225 doi: 10.1016/j.celrep.2024.114237
77. Wang C, Yang M, Liu D, Zheng C. Metabolic rescue 87. Zhang Y, Tian L, Huang G, et al. Structural basis of BAX
of α-synuclein-induced neurodegeneration through pore formation. Science. 388(6754):eadv4314.
propionate supplementation and intestine-neuron signaling doi: 10.1126/science.adv4314
in C. Elegans. Cell Rep. 2024;43(3):113865.
88. Perier C, Tieu K, Guégan C, et al. Complex I deficiency
doi: 10.1016/j.celrep.2024.113865
primes Bax-dependent neuronal apoptosis through
78. Su SH, Chen M, Wu YF, et al. Fecal microbiota transplantation mitochondrial oxidative damage. Proc Natl Acad Sci U S A.
and short-chain fatty acids protected against cognitive 2005;102(52):19126-19131.
dysfunction in a rat model of chronic cerebral hypoperfusion.
CNS Neurosci Ther. 2023;29(Suppl 1):98-114. doi: 10.1073/pnas.0508215102
89. Qi LFR, Liu S, Fang Q, et al. Ginsenoside Rg3 restores
doi: 10.1111/cns.14089
mitochondrial cardiolipin homeostasis via GRB2 to prevent
79. Rane P, Shields J, Heffernan M, Guo Y, Akbarian S, Parkinson’s disease. Adv Sci (Weinh). 2024;11(39):e2403058.
King JA. The histone deacetylase inhibitor, sodium doi: 10.1002/advs.202403058
butyrate, alleviates cognitive deficits in pre-motor stage PD.
Neuropharmacology. 2012;62(7):2409-2412. 90. Van Meer G, Voelker DR, Feigenson GW. Membrane lipids:
Where they are and how they behave. Nat Rev Mol Cell Biol.
doi: 10.1016/j.neuropharm.2012.01.026
2008;9(2):112-124.
80. Li X, Wang C, Zhu J, et al. Sodium butyrate ameliorates
oxidative stress-induced intestinal epithelium barrier injury doi: 10.1038/nrm2330
and mitochondrial damage through AMPK-mitophagy 91. Devaux PF. Static and dynamic lipid asymmetry in cell
pathway. Oxid Med Cell Longev. 2022;2022:3745135. membranes. Biochemistry. 1991;30(5):1163-1173.
doi: 10.1155/2022/3745135 doi: 10.1021/bi00219a001
81. Gao Z, Yin J, Zhang J, et al. Butyrate improves insulin 92. Haider A, Wei YC, Lim K, et al. PCYT1A regulates
sensitivity and increases energy expenditure in mice. phosphatidylcholine homeostasis from the inner nuclear
Diabetes. 2009;58(7):1509-1517. membrane in response to membrane stored curvature
elastic stress. Dev Cell. 2018;45(4):481-495.e8.
doi: 10.2337/db08-1637
doi: 10.1016/j.devcel.2018.04.012
82. Mollica MP, Mattace Raso G, Cavaliere G, et al. Butyrate
regulates liver mitochondrial function, efficiency, and 93. Kang JH, Toita R, Kawano T, Murata M, Kano A.
dynamics in insulin-resistant obese mice. Diabetes. Phospholipids and their metabolites as diagnostic biomarkers
2017;66(5):1405-1418. of human diseases. Prog Lipid Res. 2025;99:101340.
doi: 10.2337/db16-0924 doi: 10.1016/j.plipres.2025.101340
83. Xu RC, Miao WT, Xu JY, et al. Neuroprotective effects of 94. Kent C. Eukaryotic phospholipid biosynthesis. Annu Rev
sodium butyrate and monomethyl fumarate treatment Biochem. 1995;64:315-343.

Volume 4 Issue 4 (2025) 44 doi: 10.36922/AN025320086