Page 22 - ARNM-2-4

Advances in Radiotherapy
& Nuclear Medicine 68 Ga-PSMA PET CT/MRI in prostate cancer

Figure 1. Schematic representation of PRISMA workflow for manuscript’s selection
Abbreviations: PRISMA: Preferred reporting items for systematic reviews and meta-analyses; Ga-PSMA-PET: Gallium-68-prostate-specific membrane
68
antigen-positron emission tomography.
clinically significant prostate cancer (csPCa), particularly supporting its incorporation into the initial workup of
16
in ambiguous lesions such as prostate imaging-reporting high-risk PCa patients. Table 1 shows the summary of the
and data system (PI-RADS) 3, offering added value beyond main findings of the articles in this section.
MRI alone. In cases with equivocal MRI findings or
10
suspicion of clinically significant disease, Ga-PSMA-PET/ 3.2. Relation of PET findings with histopathology
68
CT has demonstrated promise as a non-invasive imaging PSMA, a type 2 transmembrane glycoprotein, is
modality for the initial diagnosis of PCa, complementing overexpressed in prostate tumors and correlates with
14
MRI. Prospective trials have underscored the importance elevated serum levels of prostate-specific antigen (PSA)
of Ga-PSMA-PET in primary PCa diagnosis. However, and higher GS, indicating its potential as a biomarker for
68
a systematic review noted notable variability in imaging PCa severity and progression. 17,18 There is a significant
68
protocols and reporting methods, necessitating association between the intensity of Ga-PSMA uptake
standardized reporting practices to enhance the broader and GS in confirmed lesions suggesting that parameters
applicability of trial results. 13 such as maximum standardized uptake value (SUV ) and
max
SUV ratio of the primary tumor could serve as predictors of
68 Ga-PSMA-PET accuracy in detecting primary PCa csPCa. Patients with higher levels of total PSA and GS
14
lesions and its potential to aid in recurrence detection tend to exhibit higher SUV values, indicating a potential
max
and staging make it a promising screening method, association between tumor aggressiveness and SUV .
max
particularly when combined with other modalities like Moreover, SUV values have been correlated with nodal
max
MRI. 15 68 Ga-PSMA-PET demonstrates high diagnostic involvement and primary tumor aggressiveness, providing
accuracy for primary prostatic lesions, with comparable valuable insights into disease prognosis and management
sensitivity, specificity, and diagnostic odds ratios, strategies. 19

Volume 2 Issue 4 (2024) 3 doi: 10.36922/arnm.4590