Page 24 - ARNM-3-2

Advances in Radiotherapy &

Nuclear Medicine

REVIEW ARTICLE
Bidirectional regulatory mechanisms of

lipids and radiotherapy: Metabolic disorders,
therapeutic interventions, and pan-cancer

clinical insights

2†
1†
Jinxia Wu and Jiahua Lyu *
1 School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
2 Department of Radiotherapy, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center,
Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu,
Sichuan, China

Abstract
Malignant tumors continue to pose a significant threat to global health. Emerging
evidence suggests that abnormal blood lipid levels may influence tumor incidence,
and cancer patients frequently exhibit dysregulated lipid profiles. Radiotherapy, a
† These authors equally contributed cornerstone in cancer treatment, has been demonstrated to modulate blood lipid
to this work. levels in patients. Conversely, blood lipid concentrations can significantly impact
*Corresponding author: the efficacy of radiotherapy and the incidence of associated complications. This
Jiahua Lyu comprehensive review delves into cutting-edge research illuminating the intricate
(winlttljh@163.com)
bidirectional interplay between blood lipid profiles and radiotherapy efficacy in
Citation: Wu J, Lyu J. Bidirectional malignant tumor patients. At the same time, it investigates the promising potential
regulatory mechanisms of lipids
and radiotherapy: Metabolic of tailored dietary modulation strategies and novel lipid-lowering therapeutics to
disorders, therapeutic interventions, enhance treatment efficacy and patient prognosis.
and pan-cancer clinical insights.
Adv Radiother Nucl Med.
2025;3(2):16-23. Keywords: Radiotherapy; Blood lipids; Cancer; Lipid metabolism; Therapeutic efficacy
doi: 10.36922/ARNM025070006
Received: February 10, 2025
1st revised: March 13, 2025
1. Introduction
2nd revised: March 28, 2025
Malignant tumors remain the leading cause of mortality worldwide. According to the
1
Accepted: April 2, 2025 Global Cancer Statistics 2022 report, there were approximately 19.97 million new cancer
Published online: April 15, 2025 cases and 9.74 million cancer-related deaths globally in 2022. 2
Copyright: © 2025 Author(s). Blood lipids, encompassing triglycerides (TG), cholesterol, cholesterol esters,
This is an Open-Access article phospholipids, and free fatty acids, play a crucial role in cellular metabolism. Emerging
distributed under the terms of the
Creative Commons Attribution evidence suggests that tumorigenesis in specific cancer types may be accompanied by
License, permitting distribution, dysregulated blood lipid metabolism. For instance, a lipid analysis of serum samples
and reproduction in any medium, from 100 breast cancer patients and 100 healthy controls revealed elevated levels of low-
provided the original work is
properly cited. density lipoprotein (LDL), TG, and total cholesterol (TC) in cancer patients compared to
healthy individuals, underscoring the prevalence of dyslipidemia in cancer populations. 3
Publisher’s Note: AccScience
Publishing remains neutral with Radiotherapy, a primary modality in cancer treatment, exerts its therapeutic
regard to jurisdictional claims in 4
published maps and institutional effects through the induction of DNA damage in malignant cells. A growing body of
affiliations. evidence indicates that radiotherapy can significantly alter patients’ blood lipid profiles.

Volume 3 Issue 2 (2025) 16 doi: 10.36922/ARNM025070006