Page 25 - ARNM-3-3
P. 25
Advances in Radiotherapy
& Nuclear Medicine Brachytherapy versus external beam in local dose escalation
Over the first 8 years following treatment, both the intermediate-risk (p=0.003) and
Main results the prevalence of severe urinary events ranged from 4% to 14% in the 3D-CRT+HDR-IRT group, and from 0% to 10% in the 3D-CRT alone. A statistically significant difference was observed only at 5.5 y (14% vs. 0%, LDR-IRT significantly improved biochemical progression-free survival in high-risk (p=0.048) A significant benefit was observed at 5 y for the LDR-IRT boost compared to the 3D-CRT was associated with higher
Median FU 7 y P=0.02) 6.5 y subsets 8.2 y 3D-CRT boost
Late toxicity GU G3, EBRT: 18.4%; p<0.0001*
- 5.2%; LDR: -
Acute toxicity GU G2, EBRT: 15.8%; LDR: 30%; p<0.0001*
- -
OS 3D-CRT: 89%; HDR IRT 88% 3D-CRT: 88%; HDR IRT: EBRT: 89%; LDR: 91% EBRT: 82%; LDR: 86% EBRT: 74%; LDR: 78% 3D-CRT: 87%; LDR-IRT: 80% 3D-CRT: 30%; LDR-IRT: 23%
At 5 y, At 7 y, 81% p=0.2 At 5 y, At 7 y, At 9 y, At 10.6 y, At 14 y,
CSS At 5-y, EBRT: LDR: 97% At 7 y, EBRT: LDR: 96% At 9-y, EBRT: LDR: 95% Abbreviations: CSS: Cancer-specific survival; DFS: Disease-free survival; DMFS: Distant metastasis-free survival; EBRT: External beam radiotherapy; fr: Fractions; FU: Follow-up; G: Grade; GU: Genito-urinary; Gy: Gray; HDR: High-dose rate; IRT: Interventional radiotherapy; LC: Local control; LDR: Low-dose rate; n: Number; OS: Overall surviv
- 98%; 94%; 92%; -
DMFS7DFS - At 5 y, EBRT: 93%; LDR: 93% At 7 y, EBRT: 93%; LDR: 91% At 9 y, EBRT: 85%; LDR: 89% -
LC 3D-CRT: 61%; HDR-IRT: 75% 3D-CRT 48% HDR IRT 66% EBRT: 84%; LDR: 89% EBRT: 75%; LDR: 86% EBRT: 62%; LDR: 83% 3D-CRT: 38% LDR-IRT: 67% 3D-CRT: 30% LDR-IRT: 53%
At 5 y, 3D-CRT: 55 Gy/13 fr; HDR IRT: At 7 y, 17Gy (+37.5 Gy 3D-CRT) p=0.04 At 5 y, 46Gy+32Gy/16fr At 7 y, LDR: 115 Gy (+46 Gy 3D-CRT) At 9 y, p<0.001 At 10.6 y, 3D-CRT: 66 Gy; LDR-IRT: 35 Gy (+40 Gy At 14 y, 3D-CRT) p<0.001
Treatment
Table 2. Summary of prostate cancer studies n pts Study Period 3D-CRT: Rand 1997 – 106; 2005 HDR-IRT: 110 EBRT: EBRT: Rand 2002 – 200; 2011 IRT: IRT: 198 3D-CRT Rand 1992 – 53; 1997 LDR-IRT: 51 y: Years; 3D-CRT: Three-dimensional conformal radiotherapy, vs.: Versus.
Volume 3 Issue 3 (2025) Authors Hoskin et al. 13 Morris et al. 14 17 Sathya et al. 15 doi: 10.36922/ARNM025160017
