Page 18 - BH-3-1

Brain & Heart TAVR in low gradient aortic stenosis

Table 2. (Continued)
First author, Year Study design Objective Number of patients/studies Outcome
included
EF and low-gradient AS
exhibited significantly higher
1-year mortality and a
significantly higher rate of low
cardiac output after TAVI.
Kataoka et al., Prospective study To analyze the prognosis of low-flow 723 patients Among Japanese small-body
2018 77 severe AS in Japanese small-body patients with severe AS, both
patients undergoing TAVR. paradoxical LF and LF-LG
severe AS were linked to poor
outcomes following TAVR.
Fischer-Rasokat A retrospective single- To determine if the prognosis of patients 2282 patients The mortality in patients
et al., 2019 78 center study with severe AS having high vs. low with LFLGAS was twice that
transvalvular mean pressure gradients in patients with HGAS after
varies after TAVR, even after strict TAVR. However, patients with
matching. paradoxical LFLGAS had
similar mortality benefits as
that of patients with HGAS.
Saito et al., 2021 79 A retrospective To compare the post-TAVR outcomes of 293 patients All-cause mortality,
observational study patients with paradoxical LFLGAS and hospitalization for valve-related
those with NFHGAS. symptoms, and worsening
congestive heart failure
were worse for patients with
pLFLGAS than for those
with NFHGAS. Patients with
pLFLGAS had a significantly
higher rate of pre-existing atrial
fibrillation/flutter, affecting the
post-TAVR outcomes.
Osman et al., 2019 80 Meta-analysis Comparing TAVI outcomes between 27204 patients from 19 Patients with classic HGAS
patients with classic HGAS and those studies showed better 30-day, midterm
with LGAS and between the three all-cause, and cardiovascular
subclasses of AS, including HG, pLFLG, mortality compared with
and Ref-LG. those with LGAS following
TAVI. Among patients with
LG severe AS, TAVI outcomes
were similar between patients
with reduced EF and those with
LGAS and pLFLGAS.
Takagi et al., 2019 81 Meta-analysis To analyze whether LFLGAS affects 5512 patients from 9 studies Patients with classical LFLGAS
survival after TAVI and compare exhibited increased early
outcomes between patients with classical mortality after TAVI compared
LFLG, paradoxical LFLG, and NFHG. with those with NFHGAS.
Classical and paradoxical
LFLGAS were associated with
increased midterm mortality
compared with NFHGAS. No
difference was observed in
early and midterm mortality
between patients with classical
LFLGAS and those with
paradoxical LFLGAS.
Rodriguez-Gabella A prospective To ascertain the clinical outcomes 493 patients There were no differences in
et al., 2018 82 multicenter study (mortality, NYHA Class III – IV) in mortality between the groups,
patients with paradoxical LFLG severe but patients with pLFLGAS
AS undergoing TAVI. more frequently showed NYHA
(Cont’d...)

Volume 3 Issue 1 (2025) 12 doi: 10.36922/bh.4017