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Eurasian Journal of Medicine and
Oncology
Single-cell RNA-seq in malignant skin tumors

24. Pich-Bavastro C, Yerly L, Di Domizio J, et al. Activin A– 35. Li X, Zhao S, Bian X, et al. Signatures of EMT,
mediated polarization of cancer-associated fibroblasts immunosuppression, and inflammation in primary and
and macrophages confers resistance to checkpoint recurrent human cutaneous squamous cell carcinoma at
immunotherapy in skin cancer. Clin Cancer Res. single-cell resolution. Theranostics. 2022;12(17):7532-7549.
2023;29(17):3498-3513.
36. Wang J, Xie D, Wu H, Li Y, Wan C. Ferroptosis-related local
doi: 10.1158/1078-0432.Ccr-23-0219 immune cytolytic activity in tumor microenvironment of
25. Yost KE, Satpathy AT, Wells DK, et al. Clonal replacement basal cell and squamous cell carcinoma. Aging (Albany NY).
of tumor-specific T cells following PD-1 blockade. Nat Med. 2022;14(9):3956-3972.
2019;25(8):1251-1259. doi: 10.18632/aging.204057
doi: 10.1038/s41591-019-0522-3 38. Yan G, Li L, Zhu S, et al. Single-cell transcriptomic analysis
26. Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL. reveals the critical molecular pattern of UV-induced
Risk factors for cutaneous squamous cell carcinoma cutaneous squamous cell carcinoma. Cell Death Dis.
recurrence, metastasis, and disease-specific death. JAMA 2021;13(1):23.
Dermatol. 2016;152(4):419-428. doi: 10.1038/s41419-021-04477-y
doi: 10.1001/jamadermatol.2015.4994 37. Schütz S, Solé-Boldo L, Lucena-Porcel C, et al. Functionally
27. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics distinct cancer-associated fibroblast subpopulations
2020: GLOBOCAN estimates of incidence and mortality establish a tumor promoting environment in squamous cell
worldwide for 36 cancers in 185 countries. CA Cancer J Clin. carcinoma. Nat Commun. 2023;14(1):5413.
2021;71(3):209-249. doi: 10.1038/s41467-023-41141-9
doi: 10.3322/caac.21660 39. Taylor MA, Kandyba E, Halliwill K, et al. Stem-cell states
28. Waldman A, Schmults C. Cutaneous squamous cell converge in multistage cutaneous squamous cell carcinoma
carcinoma. Hematol Oncol Clin North Am. 2019;33(1):1-12. development. Science. 384(6699):eadi7453.
doi: 10.1016/j.hoc.2018.08.001 doi: 10.1126/science.adi7453
29. De Jong E, Lammerts MUP, Genders RE, Bouwes Bavinck JN. 40. Fontana GA, MacArthur MR, Rotankova N, Di Filippo M,
Update of advanced cutaneous squamous cell carcinoma. Beer HD, Gahlon HL. The mitochondrial DNA common
J Eur Acad Dermatol Venereol. 2022;36 (Suppl 1):6-10. deletion as a potential biomarker of cancer-associated
fibroblasts from skin basal and squamous cell carcinomas.
doi: 10.1111/jdv.17728
Sci Rep. 2024;14(1):553.
30. Budden T, Gaudy-Marqueste C, Craig S, et al. Female
immunity protects from cutaneous squamous cell doi: 10.1038/s41598-023-50213-1
carcinoma. Clin Cancer Res. 2021;27(11):3215-3223. 41. Leonardi GC, Falzone L, Salemi R, et al. Cutaneous
doi: 10.1158/1078-0432.Ccr-20-4261 melanoma: From pathogenesis to therapy (Review). Int J
Oncol. 2018;52(4):1071-1080.
31. Que SKT, Zwald FO, Schmults CD. Cutaneous squamous
cell carcinoma: Incidence, risk factors, diagnosis, and doi: 10.3892/ijo.2018.4287
staging. J Am Acad Dermatol. 2018;78(2):237-247. 42. Bray F, Laversanne M, Sung H, et al. Global cancer statistics
doi: 10.1016/j.jaad.2017.08.059 2022: GLOBOCAN estimates of incidence and mortality
worldwide for 36 cancers in 185 countries. CA Cancer J Clin.
32. Tripathi R, Knusel KD, Ezaldein HH, Bordeaux JS, Scott JF. 2024;74(3):229-263.
Characteristics of patients hospitalized for cutaneous
squamous cell carcinoma. Dermatol Surg. 2020;46(6):742-746. doi: 10.3322/caac.21834
doi: 10.1097/dss.0000000000002117 43. Arnold M, de Vries E, Whiteman DC, et al. Global burden
of cutaneous melanoma attributable to ultraviolet radiation
33. Ji AL, Rubin AJ, Thrane K, et al. Multimodal analysis of in 2012. Int J Cancer. Sep 15 2018;143(6):1305-1314.
composition and spatial architecture in human squamous
cell carcinoma. Cell. 2020;182(2):497-514.e22. doi: 10.1002/ijc.31527
doi: 10.1016/j.cell.2020.05.039 44. Xu J, Liu W, Liu X, Zhou X, Li G. Alcohol drinking, smoking,
and cutaneous melanoma risk: Mendelian randomization
34. Sun YZ, Zou DD, Li XJ, et al. Single-cell sequencing analysis. Gac Sanit. 2023;37:102351.
highlights heterogeneity and malignant progression in
actinic keratosis and cutaneous squamous cell carcinoma. doi: 10.1016/j.gaceta.2023.102351
Elife. 2023;12:e85270.
45. Ali Z, Yousaf N, Larkin J. Melanoma epidemiology, biology
doi: 10.7554/eLife.85270 and prognosis. EJC Suppl. 2013;11(2):81-91.

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