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Eurasian Journal of Medicine and
Oncology
Single-cell RNA-seq in malignant skin tumors

doi: 10.3389/fcell.2022.874429 doi: 10.3390/ijms21134576
67. Deng W, Ma Y, Su Z, et al. Single-cell RNA-sequencing 77. Castellani G, Buccarelli M, Arasi MB, et al. BRAF
+
analyses identify heterogeneity of CD8 T cell subpopulations mutations in melanoma: Biological aspects, therapeutic
and novel therapy targets in melanoma. Mol Ther Oncolytics. implications, and circulating biomarkers. Cancers (Basel).
2021;20:105-118. 2023;15(16):4026.
doi: 10.1016/j.omto.2020.12.003 doi: 10.3390/cancers15164026
68. Yan M, Hu J, Ping Y, et al. Single-cell transcriptomic 78. Augustin RC, Newman S, Li A, et al. Identification of tumor-
analysis reveals a tumor-reactive T cell signature associated intrinsic drivers of immune exclusion in acral melanoma.
with clinical outcome and immunotherapy response in J Immunother Cancer. 2023;11(10):e007567.
melanoma. Front Immunol. 2021;12:758288. doi: 10.1136/jitc-2023-007567
doi: 10.3389/fimmu.2021.758288 79. Capparelli C, Purwin TJ, Glasheen M, et al. Targeting SOX10-
69. Lian W, Xiang P, Ye C, et al. Single-cell RNA sequencing deficient cells to reduce the dormant-invasive phenotype
analysis reveals the role of cancerassociated fibroblasts in state in melanoma. Nat Commun. 2022;13(1):1381.
skin melanoma. Curr Med Chem. 2024;31(42):7015-7029. doi: 10.1038/s41467-022-28801-y
doi: 10.2174/0109298673282799231211113347 80. Purwin TJ, Caksa S, Sacan A, Capparelli C, Aplin AE. Gene
70. Novotny J, Strnadova K, Dvorankova B, et al. Single-Cell signature reveals decreased SOX10-dependent transcripts in
RNA sequencing unravels heterogeneity of the stromal malignant cells from immune checkpoint inhibitor-resistant
niche in cutaneous melanoma heterogeneous spheroids. cutaneous melanomas. iScience. 2023;26(9):107472.
Cancers (Basel). 2020;12(11):3324. doi: 10.1016/j.isci.2023.107472
doi: 10.3390/cancers12113324 81. Randic T, Magni S, Philippidou D, et al. Single-cell
71. Sun H, Deng K, Zhou X, et al. A novel gene prognostic transcriptomics of NRAS-mutated melanoma transitioning
signature lymphocyte cytosolic protein 2 regulates to drug resistance reveals P2RX7 as an indicator of early
melanoma progression by activating tumor-infiltrating drug response. Cell Rep. 2023;42(7):112696.
CD8 T-cells through the interferon regulatory factor 5 doi: 10.1016/j.celrep.2023.112696
+
signaling pathway. Tumor Discov. 2023;2(1):318.
82. Kim S, Carvajal R, Kim M, Yang HW. Kinetics of RTK
doi: 10.36922/td.318 activation determine ERK reactivation and resistance
72. Goding SR, Wilson KA, Xie Y, et al. Restoring immune to dual BRAF/MEK inhibition in melanoma. Cell
function of tumor-specific CD4 T cells during recurrence Rep. 2023;42(6):112570.
+
of melanoma. J Immunol. 2013;190(9):4899-4909. doi: 10.1016/j.celrep.2023.112570
doi: 10.4049/jimmunol.1300271 83. Dong Y, Chen Z, Yang F, Wei J, Huang J, Long X. Prediction
73. Kim J, Kim TJ, Chae S, et al. Targeted deletion of CD244 on of immunotherapy responsiveness in melanoma through
monocytes promotes differentiation into anti-tumorigenic single-cell sequencing-based characterization of the tumor
macrophages and potentiates PD-L1 blockade in melanoma. immune microenvironment. Transl Oncol. 2024;43:101910.
Mol Cancer. 2024;23(1):45. doi: 10.1016/j.tranon.2024.101910
doi: 10.1186/s12943-024-01936-w 84. Statescu L, Trandafir LM, Tarca E, et al. Advancing cancer
research: Current knowledge on cutaneous neoplasia. Int J
74. Zhang Y, Bai Y, Ma XX, et al. Clinical-mediated discovery
of pyroptosis in CD8 T cell and NK cell reveals melanoma Mol Sci. 2023;24(13):11176.
+
heterogeneity by single-cell and bulk sequence. Cell Death doi: 10.3390/ijms241311176
Dis. 2023;14(8):553. 85. Rao A, Barkley D, Franca GS, Yanai I. Exploring tissue
doi: 10.1038/s41419-023-06068-5 architecture using spatial transcriptomics. Nature.
2021;596(7871):211-220.
75. Shi A, Yan M, Pang B, et al. Dissecting cellular states
of infiltrating microenvironment cells in melanoma by doi: 10.1038/s41586-021-03634-9
integrating single-cell and bulk transcriptome analysis. 86. Liu T, Ye J, Hu C, et al. Artificial intelligence-enabled spatially
BMC Immunol. 2023;24(1):52. resolved transcriptomics reveal spatial tissue organization of
doi: 10.1186/s12865-023-00587-8 multiple tumors. Tumor Discov. 2024;3(1):2049.
76. Czarnecka AM, Bartnik E, Fiedorowicz M, Rutkowski P. doi: 10.36922/td.2049
Targeted therapy in melanoma and mechanisms of 87. Wang L, Hu Y, Gao L. Adjustment of scRNA-seq data to
resistance. Int J Mol Sci. 2020;21(13):4576.

Volume 9 Issue 1 (2025) 14 doi: 10.36922/ejmo.5809