Page 50 - EJMO-9-1
P. 50

Eurasian Journal of Medicine and
            Oncology
                                                                              BRCA VUS in breast cancer in MENA region


            influencing BC susceptibility in this region, paving the way   mutations. J Natl Cancer Inst. 2003;95(6):448-457.
            for improved patient outcomes and tailored interventions.     doi: 10.1093/jnci/95.6.448
            Acknowledgments                                    6.   Mavaddat N, Peock S, Frost D, et al. Cancer risks for BRCA1 and
                                                                  BRCA2 mutation carriers: Results from prospective analysis
            None.                                                 of EMBRACE. J Natl Cancer Inst. 2013;105(11):812-822.
            Funding                                               doi: 10.1093/JNCI/DJT095

            None.                                              7.   Miki  Y, Swensen J,  Shattuck-Eidens  D,  et al.  A  strong
                                                                  candidate for the breast and ovarian cancer susceptibility
            Conflict of interest                                  gene BRCA1. Science. 1994;266(5182):66-71.

            The authors declare that they have no competing interests.     doi: 10.1126/science.7545954
                                                               8.   Wooster R, Bignell G, Lancaster J,  et al. Identification
            Author contributions                                  of the breast cancer susceptibility gene BRCA2.  Nature.
            Conceptualization: Oubaida Elbiad, Abdelilah Laraqui  1995;378(6559):789-792.
            Formal analysis: Oubaida Elbiad, Bouabid Badaoui,      doi: 10.1038/378789a0
               Oumaima Mazour                                  9.   Domchek SM, Weber BL. Clinical management of BRCA1 and
            Writing – original draft: Oubaida Elbiad, Abdelilah Laraqui  BRCA2 mutation carriers. Oncogene. 2006;25(43):5825-5831.
            Writing – review & editing: Oubaida Elbiad, Abdelilah
               Laraqui, Khalid Ennibi                             doi: 10.1038/SJ.ONC.1209881
                                                               10.  Lindor NM, Guidugli L, Wang X,  et al.  A  review of a
            Ethics approval and consent to participate            multifactorial  probability-based model for classification
                                                                  of BRCA1 and BRCA2 variants of uncertain significance
            Not applicable.
                                                                  (VUS). Hum Mutat. 2012;33(1):8-21.
            Consent for publication                               doi: 10.1002/humu.21627
            Not applicable.                                    11.  Cragun D, Dean M, Baker D, et al. The development and
                                                                  evaluation of novel patient educational material for a variant
            Availability of data                                  of uncertain significance (VUS) result in hereditary cancer
                                                                  genes. Curr Oncol. 2024;31(6):3361-3378.
            Data are available on reasonable request by contacting the
            corresponding author directly.                        doi: 10.3390/curroncol31060256
                                                               12.  Slavin TP, Manjarrez S, Pritchard CC, Gray S, Weitzel JN.
            References                                            The effects of genomic germline variant reclassification on
            1.   Bray F, Laversanne M, Sung H, et al. Global cancer statistics   clinical cancer care. Oncotarget. 2019;10(4):417-423.
               2022: GLOBOCAN estimates of incidence and mortality      doi: 10.18632/oncotarget.26501
               worldwide for 36 cancers in 185 countries. CA Cancer J Clin.
               2024;74:229-263.                                13.  Bozsik A, Papp J, Grolmusz VK, Patócs A, Oláh E, Butz H.
                                                                  Reclassification of Five BRCA1/2 variants with unknown
               doi: 10.3322/caac.21834                            significance using complex functional study.  Cancer Res
            2.   Elengoe A. A short review on breast cancer. Int J Biotechnol   Treat. 2022;54(4):970-984.
               Biomed. 2024;1(1):1-11.                            doi: 10.4143/crt.2021.1078
               doi: 10.31674/ijbb.2024.v01i01.001              14.  Richards S, Aziz N, Bale S, et al. Standards and guidelines for
            3.   World Health Organisation.  Latest Global Cancer Data :   the interpretation of sequence variants: A joint consensus
               Cancer Burden Rises to 18. 1 Million New Cases and 9. 6   recommendation of the  American  College  of Medical
               Million Cancer Deaths in 2018. France: International Agency   Genetics and Genomics and the Association for Molecular
               for Research on Cancer; 2018. p. 13-15.            Pathology. Genet Med. 2015;17(5):405-424.
            4.   Safiri S, Noori M, Nejadghaderi SA, et al. Burden of female      doi: 10.1038/gim.2015.30
               breast cancer in the Middle East and North Africa region,   15.  Tazzite A, Jouhadi H, Nadifi S, et al. BRCA1 and BRCA2
               1990–2019. Arch Public Health. 2022;80(1):168.
                                                                  germline mutations in Moroccan breast/ovarian cancer
               doi: 10.1186/s13690-022-00918-y                    families: Novel mutations and unclassified variants. Gynecol
                                                                  Oncol. 2012;125(3):687-692.
            5.   Dite GS, Jenkins MA, Southey MC,  et al. Familial risks,
               early-onset breast cancer, and BRCA1 and BRCA2 germline      doi: 10.1016/j.ygyno.2012.03.007


            Volume 9 Issue 1 (2025)                         42                              doi: 10.36922/ejmo.5800
   45   46   47   48   49   50   51   52   53   54   55