Page 45 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
BRCA VUS in breast cancer in MENA region

(Cont'd...)

ClinVar classification Benign Benign Benign Uncertain significance Benign Not reported Benign Uncertain significance Benign Conflicting interpretations of pathogenicity Benign Not reported Not provided Not reported Benign Benign Not reported Benign Benign Benign Benign Benign Benign Benign Benign Benign Not reported Not provided Benign

dbSNP reference rs1060915 rs1799955 rs169547 rs746057464 rs1799966 - rs9534262 rs1466452770 rs11571746 rs587782313 rs1801426 - rs 2137453020 rs11571661 rs273900734 rs3092994 - rs1799943 rs11571574 rs4942486 rs9595456 rs11571824 rs11571622 Rs799923 rs273902772 rs2126042 - rs2154418740 rs1800709

Consequence p.Ser1436Ser p.Ser2414= p.Ala2466Val p.Arg2488Gly p.Ser1613Gly p.Asn1592Lys Non coding p.Val2652Met p.Ser2835Pro p.Ala3122Thr p.Ile3412Val p.Asn66Tyr p.Leu209Phe Non coding Non-coding Non coding Non coding Non-coding Non-coding Non codeing Non coding Non coding Non-coding Non coding Non coding Non-coding Non coding p.Ser611* p.Arg841Trp

Mutation type S MS MS MS MS MS IVS MS MS MS MS MS MS IVS IVS IVS IVS 5′UTR IVS IVS IVS IVS IVS IVS IVS IVS IVS MS MS

Genetic variant c. 4308T > C c. 7242A > G c. 7397T > C c. 7462A > G c. 4837A > G c. 4776C > A c. 7806_14T > C c. 7954G > A c. 8503T > C c. 9364G > A c. 10234A > G c. 196A > T c. 625C > T c. 6841 + 80delTTAA c. 4485_63C > G c. 5152 + 66G > A c. 8488_143G > A c.-26G > A c. 67 + 62T > G c. 8735_66T > C c. 9257_83G > A c. 9648 + 106delT c. 516 + 21A > T c. 442_34C > T c. 548_58delT c. 681 + 56C > T c. 594_67G > T c. 1832T > C c. 2

Exon Exon 13 Exon 14 Exon 14 Exon 15 Exon 16 Exon 16 Exon 17 Exon 17 Exon 20 Exon 25 Exon 27 Exon 5 Exon 7 intron 11 intron 14 Intron 17 intron 19 intron 2 intron 2 intron 21 intron 24 intron 26 intron 6 intron 7 intron 8 intron 8 Intron 9 Exon 10 Exon 10

Gene BRCA1 BRCA2 BRCA2 BRCA2 BRCA1 BRCA1 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA1 BRCA2 BRCA2 BRCA1 BRCA1 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA1 BRCA1 BRCA2 BRCA1 BRCA1 BRCA1

Year of publication 2012 2012 2012 2012 2012 2012 2012 2020 2012 2012 2012 2012 2020 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2007 2015

Authors Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Laraqui et al. 15 Taazite et al. 15 Mansouri et al. 17 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Laraqui et al. 19 Mansouri et al. 17 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite

Table 2. (Continued) Country Region Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocc

Volume 9 Issue 1 (2025) 37 doi: 10.36922/ejmo.5800