Page 44 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
BRCA VUS in breast cancer in MENA region

(Cont'd...)

ClinVar classification Benign Benign Benign Benign Benign Benign Benign Benign Benign Likely benign Benign Benign Benign Not reported Not reported Not reported Not reported Not reported Not reported Benign Benign Benign Benign Likely benign Benign Benign Benign Benign Benign Benign Benign

dbSNP reference rs144848 rs1801439 rs1799950 rs80358329 rs4986850 Rs1799949 rs16940 rs55746541 Rs799917 rs1800740 rs16941 rs2227945 Rs16942 - - - - - - rs1801499 rs1799944 rs1801406 rs1799952 rs786202569 rs206075 rs55953736 rs206076 rs56248502 rs80358784 rs11571657 rs56248502

Consequence p.Asn372His p.Ser455= p.Gln356Arg p.Ser616del p.Asp693Asn p.Ser694Ser p.Leu771Leu p.Gln804His p.Pro871Leu p.Gly911Gly p.Glu1038Gly p.Ser1140Gly p.Lys1183Arg p.Asn473Tyr p.Ser647Arg p.Met751Leu p.Gln957Lys p.Gln975His p.Ala1039Ser p.His743His p.Asn991Asp p.Lys1132= p.Ser1172ser p.Asp1269= p.Leu1521Leu p.His2116Arg p.Val2171= p.Ile1364Leu p.Asn1878Lys p.Asn1880Lys p.Ile1364Val

Mutation type MS S MS IFD MS S S MS MS S MS MS MS MS MS MS MS MS MS S MS S S S S MS S MS MS MS MS

Genetic variant c. 1114A > C c. 1365A > G c. 1067A > G c. 1846delTCT c. 2077G > A c. 2082C > T c. 2311T > C c. 2412G > C c. 2612C > T c. 2733A > G c. 3113A > G c. 3418A > G c. 3548A > G c. 1417A > T c. 1941T > G c. 2251A > C c. 2869C > A c. 2925A > T c. 3115G > T c. 2229T > C c. 2971A > G c. 3396A > G c. 3516G > A c. 3807C > T c. 4563G > A c. 6347A > G c. 6513C > G c. 4090A > C c. 5634C > G c. 5640T > G c. 4090A > G

Exon Exon 10 Exon 10 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11

Gene BRCA2 BRCA2 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2

Year of publication 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2020 2020 2020 2020

Authors Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Laraqui et al. 19 Laraqui et al. 19 Laraqui et al. 19 Laraqui et al. 19 Laraqui et al. 19 Laraqui et al. 19 Taazite et al. 15 Taazite et al. 15 Taazite et al. 15 Taazite et

Table 2. (Continued) Country Region Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocco North Africa Morocc

Volume 9 Issue 1 (2025) 36 doi: 10.36922/ejmo.5800