Page 39 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
BRCA VUS in breast cancer in MENA region

(Cont'd...)

ClinVar classification Conflicting interpretations of pathogenicity Benign Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Uncertain significance Not reported Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Confl

dbSNP reference rs886038001 rs56336919 rs1060502347 rs397507223 rs771076131 rs759878392 rs748221377 - rs730881442 rs775869160 rs769712441 rs80359036 rs747489126 rs431825287 rs2072424315 rs80358577 rs80358598 - - -

Consequence p.Gln867Glu p.Val1181Ile p.Glu1210Gly p.Ala1293Pro p.Asn268Lys p.His437Tyr p.Val457Ile p.Glu881Gln p.Asp420Gly p.Ile429Thr p.Ser889Phe p.Gly267Glu p.Glu456Asp p.Ile594val p.Glu621Ser p.Thr1104Pro p.Met1168Lys - - p.Gly904Arg

Mutation type MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS

Genetic variant c. 2599C > G c. 3541G > A c. 3629A > G c. 3877G > C c. 804C > G c. 1309C > T c. 1369G > A c. 2641G > C c. 1259A > G c. 1286T > C c. 2666C > T c. 800G > A c. 1368G > C c. 1780A > C c. 1861_1863delGAAinsAGC c. 3310A > C c. 3503T > A c. 1947G > T c. 2519T > G c. 2710G > A

Exon Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11

Gene BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2

Year of publication 2020 2020 2020 2020 2020 2020 2020 2020 2021 2021 2021 2020 2020 2020 2020 2020 2020 2020 2020 2020

Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Gezdirici et al. 47 Gezdirici et al. 47 Gezdirici et al. 47 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46

Authors

Table 2. (Continued) Country Region Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East

Volume 9 Issue 1 (2025) 31 doi: 10.36922/ejmo.5800