Page 41 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
BRCA VUS in breast cancer in MENA region

(Cont'd...)

ClinVar classification Uncertain significance Uncertain significance Uncertain significance Not reported Conflicting interpretations of pathogenicity Uncertain significance Uncertain significance Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Pathogenic/likely pathogenic Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Pathogenic/likely pathogenic C

dbSNP reference rs80358908 rs1060502417 rs398122570 - rs273901741 rs2052392087 rs774505084 rs80358973 rs80358982 rs80359012 rs80359076 rs80359094 rs80357410 rs80359104 rs1555288163 rs878853614 rs56179254 rs11571833 rs1593202262 rs748237097 rs80358531 rs80358603 rs757612558 rs80357209

Consequence p.Gly2281Glu p.Asp2294Glu p.Lys2308Glu - p.Ser1577Tyr p.Tyr1625Asn p.Ala1627Thr p.Arg2494Gln p.Arg2520Leu p.His2623Arg p.Arg2784Gln p.Val2818Ile p.Cys24Gly p.Arg2842Cys p.Ala2902Thr p.Gly2961Ser p.Ala3029Thr p.Lys3326Ter p.Lys3360Glu p.Ala3372Val p.Pro94Ser p.Arg118His - p.Thr77Met

Mutation type MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS MS NS MS MS MS MS IVS MS

Genetic variant c. 6842G > A c. 6882C > G c. 6922A > G c. 7435G > C c. 4730C > A c. 4873T > A c. 4879G > A c. 7481G > A c. 7559G > T c. 7868A > G c. 8351G > A c. 8452G > A c. 70T > G c. 8524C > T c. 8704G > A c. 8881G > A c. 9085G > A c. 9976A > T c. 10078A > G c. 10115C > T c. 280C > T c. 353G > A c. 425 + 4T > G c. 230C > T

Exon Exon 12 Exon 12 Exon 12 Exon 14 Exon 15 Exon 15 Exon 15 Exon 15 Exon 15 Exon 17 Exon 19 Exon 19 Exon 2 Exon 20 Exon 21 Exon 22 Exon 23 Exon 27 Exon 27 Exon 27 Exon 3 Exon 4 Exon 4 Exon 5

Gene BRCA2 BRCA2 BRCA2 BRCA2 BRCA1 BRCA1 BRCA1 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA1 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA1

Year of publication 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020

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Authors

Table 2. (Continued) Country Region Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey

Volume 9 Issue 1 (2025) 33 doi: 10.36922/ejmo.5800