Page 42 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
BRCA VUS in breast cancer in MENA region

(Cont'd...)

ClinVar classification Conflicting interpretations of pathogenicity Benign Likely benign Not reported Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Uncertain significance Benign Likely benign Conflicting interpretations of pathogenicity Likely benign Conflicting interpretations of pathogenicity Uncertain significance Conflicting interpretations of pathogenicity Conflicting interpret

dbSNP reference rs397509298 rs1800704 - - rs276174809 rs2137467635 rs397509136 rs1800063 rs1800740 rs886040193 rs147448807 rs80358827 rs80358526 rs2137500806 rs1064793412 rs2137488810 rs876659609 - rs4987048 rs573514896 rs748854546 rs2137526252 rs80358766 rs2137526607

Consequence p.Ser186Ala p.Met1008Ile p.Asn916= - p.Lys502Gln p.Asp367Asn p.Glu1358Lys p.Thr327Thr p.Gly911Gly p.Gln1356Lys p.Gly1371= p.Thr1980Ile p.Asn886Ser p.Cys1290Ser p.Ser879Tyr p.Val891= p.Thr1185=) p.Ala1799= p.Asp1902Asn p.Ile1851= p.Ser1992= p.Ser2103= rs2137467635 p.His2116Asp

Mutation type MS MS S S MS MS MS S S MS S MS MS MS MS S S S MS S S S MS MS

Genetic variant c. 556T > G c. 3024G > A c. 2748T > C c. 3114A > G c. 1504A > C c. 1099G > A c. 4072G > A c. 981A > G c. 2733A > G c. 4066C > A c. 4113G > A c. 5939C > T c. 2657A > G c. 3868T > A c. 2636C > A c. 2673C > G c. 3555A > T c. 5397A > T c. 5704G > A c. 5553C > T c. 5976A > G c. 6309A > C c. 5428G > T c. 6346C > G

Exon Exon 8 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11

Gene BRCA1 BRCA1 BRCA1 BRCA1 BRCA2 BRCA2 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2

Year of publication 2020 2008 2012 2012 2016 2012 2008 2008 2008 2012 2012 2016 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012 2012

Bahsi and Erdem 46 Uhrhammer et al. 21 Cherbal et al. 20 Cherbal et al. 20 Henouda et al. 22 Cherbal et al. 20 Uhrhammer et al. 21 Uhrhammer et al. 21 Uhrhammer et al. 21 Cherbal et al. 20 Cherbal et al. 20 Henouda et al. 22 Cherbal et al. 20 Cherbal et al. 20 Cherbal et al. 20 Cherbal et al. 20 Cherbal et al. 20 Cherbal et al. 20 Cherbal et al. 20 Cherbal et al. 20 Cherbal et al. 20 Cherbal et al. 20 Cherba

Authors

Table 2. (Continued) Country Region Turkey Middle East Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria North Africa Algeria

Volume 9 Issue 1 (2025) 34 doi: 10.36922/ejmo.5800