Page 40 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
BRCA VUS in breast cancer in MENA region

(Cont'd...)

ClinVar classification Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Uncertain significance Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Uncertain significance Benign Conflicting interpretations of pathogenicity Uncertain significance Conflicting interpretations of pathogenicity Conflicting interpr

dbSNP reference rs786201837 - rs1064795381 rs80358571 rs398122761 rs1298550035 rs397507697 rs80359432 rs398122792 rs397507775 rs80358770 rs80358811 rs1566233345 rs431825337 rs80358889 rs1135401833 rs768327850 rs80357486 -

Consequence p.Met927Val p.Thr933Lys p.Val1078del p.Ile1086Val p.His1101Arg p.Ser1106Arg p.Met1300_ Thr1301delinsIle p.Glu1382del p.Asp1709Tyr p.Leu1740_ Ser1741del p.Ile1827Val p.Ser1946Pro p.Thr1954Ala p.Arg2027Lys p.Val2205Met p.Lys2188Glu p.Pro1425Ser p.Ser1448Gly p.Ala1416Pro

Mutation type MS MS IFD MS MS MS IFID IFD MS IFD MS MS MS MS MS MS MS MS MS

Genetic variant c. 2779A > G c. 2798C > A c. 3232_3234delGTT c. 3256A > G c. 3302A > G c. 3318C > G c. 3900_3902delGAC c. 4146_4148delAGA c. 5125G > T c. 5218_5223delTTAAG c. 5479A > G c. 5836T > C c. 5860A > G c. 6080G > A c. 6613G > A c. 6562A > G c. 4273C > T c. 4342A > G c. 4246G > C

Exon Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 12 Exon 12 Exon 12

Gene BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA1 BRCA1 BRCA1

Year of publication 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2020 2021 2020 2020 2021

Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Bahsi and Erdem 46 Gezdirici et al. 47 Bahsi and Erdem 46 Bahsi and Erdem 46 Gezdirici et al. 47

Authors

Table 2. (Continued) Country Region Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East Turkey Middle East

Volume 9 Issue 1 (2025) 32 doi: 10.36922/ejmo.5800