Page 34 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
BRCA VUS in breast cancer in MENA region

(Cont'd...)

ClinVar classification Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Uncertain significance Conflicting interpretations of pathogenicity Uncertain significance Uncertain significance Conflicting interpretations of pathogenicity Uncertain significance Uncertain significance Uncertain significance Unc

dbSNP reference rs1555282656 rs786202836 rs587782062 rs730881550 rs1555582594 rs80358954 rs398122710 rs80359135 rs730881502 rs2137663534 rs2073050972 rs776730435 rs80358726 rs62625285 rs1555583976 rs587782093 - - - rs56191579 rs80358656 rs1265352633 -

Consequence p.Lys799Arg p.Asp1709Ala p.Lys789Arg p.Ala2306Pro p.Glu1478Asp p.Lys2434Thr p.Glu2878Gln p.Gln2925Arg p.Thr1852Ile p.Ser3252_ Gly3255del p.Asp3261Asn p.Ser93Ala p.Pro168Ala p.Gly160Arg - - - p.Ser873Pro p.Gly1319Val p.Gly2044Ala p.Thr1354Met p.Tyr1552His p.A22V

Mutation type MS MS MS MS MS MS MS MS MS IFD MS MS MS MS IVS IVS IVS MS MS MS MS MS MS

Genetic variant c. 2396A > G c. 5126A > C c. 2366A > G c. 6916G > C c. 4434G > C c. 7301A > C c. 8632G > C c. 8774A > G c. 5555C > T c. 9754_9765del c. 9781G > A c. 277T > G c. 502C > G c. 478G > A c. 4357 + 5G > A c. 8332-3C > G c. 632-5T > C c. 2617T > C c. 3956G > T c. 6131G > C c. 4061C > T c. 4654T > C c. 65C > T

Exon Exon 11 Exon 11 Exon 11 Exon 12 Exon 13 Exon 14 Exon 20 Exon 22 Exon 23 Exon 27 Exon 27 Exon 3 Exon 6 Exon 7 Intron 12 Intron 18 Exon ? Exon 10 Exon 10 Exon 11 Exon 11 Exon 14 Exon 2

Gene BRCA2 BRCA2 BRCA2 BRCA2 BRCA1 BRCA2 BRCA2 BRCA2 BRCA1 BRCA2 BRCA2 BRCA2 BRCA2 BRCA1 BRCA1 BRCA2 BRCA2 BRCA1 BRCA1 BRCA2 BRCA2 BRCA1 BRCA2

Year of publication 2021 2021 2021 2018 2018 2021 2021 2018 2021 2021 2021 2021 2018 2021 2021 2021 2019 2019 2019 2012 2017 2012 2017

Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 32 Abdel-Razeq et al. 32 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 32 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 32 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Chantal et al. 42 Chantal et al. 42 Chantal et al. 42

Authors Jalkh et al. 39 Jalkh et al. 41 Jalkh et al. 39 Jalkh et al. 41

Table 2. (Continued) Country Region Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Lebanon Middle East Lebanon Middle East Lebanon Middle East Lebanon Middle East Le

Volume 9 Issue 1 (2025) 26 doi: 10.36922/ejmo.5800