Page 33 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
BRCA VUS in breast cancer in MENA region

(Cont'd...)

ClinVar classification Not provided Likely benign Not provided Not provided Not provided Uncertain significance Conflicting interpretations of pathogenicity Likely benign Conflicting interpretations of pathogenicity Uncertain significance Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Conflicting interpretations of pathogenicity Uncertain s

dbSNP reference rs1555601019 rs80356827 rs80357031 rs571834423 rs2051496536 rs1169190081 rs80358962 rs80357400 rs1555281730 rs80358327 rs1597865440 rs398122675 rs775339017 rs80357039 - rs730881525 rs143667871 rs80358693 rs2072509204 rs1449458592 rs587781536 rs80358925

Consequence p.Val11Leu p.Val14_Ile15= p.Ile15phe p.Gln1756His p.Lys1759Glu p.Ile247Phe p.Ile247Thr p.Phe486Leu p.Glu359Lys p.Ile483del p.Ser1050Thr p.Glu1214Asp p.Asp1343Val p.Gln284Arg p.Glu2193Lys p.Lys1226Gln p.Ile1418Val p.Val1532Phe p.Lys1541Gln p.Ala1648Val p.Asp1864Asn p.Ala691Val

Mutation type MS S MS MS MS MS MS MS MS IFD MS MS MS MS MS MS MS MS MS MS MS MS

Genetic variant c. 31G > T c. 42C > A c. 43A > T c. 5268G > T c. 5275A > G c. 739A > T c. 740T > C c. 1458T > G c. 1075G > A c. 1446_1448del c. 3149G > C c. 3642G > T c. 4028A > T c. 851A > G c. 6577G > A c. 3676A > C c. 4252A > G c. 4594G > T c. 4621A > C c. 4943C > T c. 5590G > A c. 2072C > T

Exon Exon 19 Exon 19 Exon 19 Exon 19 Exon 19 Exon 9 Exon 9 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 10 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11 Exon 11

Gene BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA2 BRCA2 BRCA1 BRCA2 BRCA1 BRCA1 BRCA1 BRCA1 BRCA1 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2 BRCA2

Year of publication 2021 2021 2021 2021 2021 2021 2021 2019 2019 2021 2021 2021 2021 2021 2018 2021 2021 2021 2021 2021 2021 2021

AbdelHamid et al. 31 AbdelHamid et al. 31 AbdelHamid et al. 31 AbdelHamid et al. 31 AbdelHamid et al. 31 AbdelHamid et al. 31 AbdelHamid et al. 31 Chantal et al. 38 Chantal et al. 38 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 32 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq et al. 33 Abdel-Razeq e

Authors

Table 2. (Continued) Country Region Egypt Middle East Egypt Middle East Egypt Middle East Egypt Middle East Egypt Middle East Egypt Middle East Egypt Middle East Iraq Middle East Iraq Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle East Jordan Middle Ea

Volume 9 Issue 1 (2025) 25 doi: 10.36922/ejmo.5800