Page 28 - EJMO-9-1

Eurasian Journal of Medicine and
Oncology
BRCA VUS in breast cancer in MENA region

Table 1. Details of studies examining BRCA1 and BRCA2 in the Middle East and North Africa region
Region Country Authors Year of Numbers Number of Methods Covered gene region
publication of patients VUS detected (s)
Middle East Bahrain Al Hannan 2019 25 24 NGS BRCA1 and BRCA2
et al. 37
Middle East Cyprus Loizidou 2007 26 16 Sanger sequencing BRCA1 and BRCA2
et al. 43
Middle East Cyprus Loizidou 2017 527 32 Direct sequencing; BRCA1 and BRCA2
et al. 44 MLPA
Middle East Egypt AbdelHamid 2021 103 31 HRM; Direct BRCA1: exons 2 and 20;
et al. 31 sequencing BRCA2: exons 9 and 11
Middle East Iraq Chantal 2019 42 7 Direct sequencing BRCA1 and BRCA2
et al. 38
Middle East Jordan Abdel-Razeq 2018 100 6 Direct sequencing BRCA1 and BRCA2
et al. 32
Middle East Jordan Abdel-Razeq 2021 616 29 NGS; MLPA BRCA1 and BRCA2
et al. 33
Middle East Lebanon Jalkh 2012 72 56 Direct sequencing BRCA1 and BRCA2
et al. 39
Middle East Lebanon Jalkh 2017 45 7 Whole exome BRCA1 and BRCA2
et al. 41 sequencing
Middle East Lebanon El Saghir 2015 250 34 Direct sequencing; BRCA1 and BRCA2
et al. 40 MLPA
Middle East Lebanon Chantal 2019 281 26 Direct sequencing BRCA1 and BRCA2
et al. 42
Middle East Saudi Arabia El-Harith 2002 40 3 Direct sequencing BRCA1: exon 11-
et al. 50 BRCA2: exon 10 and 11
Middle East Saudi Arabia Alhuqail 2018 173 1 NGS; Sanger BRCA1 and BRCA2
et al. 35 sequencing
Middle East Saudi Arabia Abulkhair 49 2018 310 45 NGS BRCA1 and BRCA2
Middle East Turkey Bahsi and Erdem 46 2019 1419 91 NGS BRCA1 and BRCA2
Middle East Turkey Cecener 2019 603 7 Direct sequencing BRCA1 and BRCA2
et al. 45 and HDA
Middle East Turkey Gezdirici 2021 149 7 NGS BRCA1 and BRCA2
et al. 65
Middle East Turkey Duzkale and Teker. 48 2021 31 7 NGS BRCA1 and BRCA2
North Africa Algeria Cherbal 2012 101 45 Direct sequencing; BRCA1 and BRCA2
et al. 20 MLPA
North Africa Algeria Henouda 2016 40 4 Direct sequencing; BRCA1 and BRCA2
et al. 22 MLPA
North Africa Algeria Uhrhammer 2008 64 14 Direct sequencing, BRCA1
et al. 21 MLPA
North Africa Morocco Bakkach 2020 33 1 NGS BRCA1 and BRCA2
et al. 16
North Africa Morocco Mansouri 2020 32 6 NGS BRCA1 and BRCA2
et al. 17
North Africa Morocco Laraqui 2012 121 10 Direct sequencing BRCA1
et al. 19
North Africa Morocco Laraqui 2021 30 1 NGS BRCA1 and BRCA2
et al. 18
(Cont'd...)

Volume 9 Issue 1 (2025) 20 doi: 10.36922/ejmo.5800