Page 134 - EJMO-9-2

Eurasian Journal of Medicine and
Oncology
Anticancer effects of phytocomposites

Sumadain C, a naturally occurring monoterpene-chalcone binding affinity of the selected phytocompounds is
conjugate derived from plant sources, has garnered significant highly promising, suggesting that future experimental
attention due to its potential cytotoxic effects on various studies could develop them into chemotherapeutic
cancers. It induces programmed cell death in cancer cells agents. Integrating these phytocompounds into cancer
through multiple apoptotic pathways, leading to cytotoxic treatment holds great promise for enhancing therapeutic
processes. Sumadain C modulates pro-apoptotic proteins, outcomes and improving the overall well-being of
inhibits anti-apoptotic proteins, and triggers mitochondrial affected patients. CADD emerges as a promising source
malfunction, resulting in caspase activation and DNA of drug discovery, potentially revolutionizing cancer
breakage. In addition, it causes cell cycle arrest by disrupting therapeutics.
numerous angiogenic signaling pathways and suppressing
tumor vascularization. It hinders cell survival, proliferation, Acknowledgments
84
and metastasis by modifying carcinogenic signaling pathways. None.
Notably, sumadain C demonstrated potent cytotoxicity effects
against three cell lines with IC values of 13.00, 15.93, and Funding
50
12.78 µg/mL, respectively. For comparison, cisplatin, used
85
as a positive control, had IC values of 13.18, 31.91, and None.
50
16.39 µg/mL, respectively. B-cell lymphoma 2 was found to Conflict of interest
85
be the target of sumadain C through network pharmacology
techniques, like molecular docking, and was verified by a The authors declare no potential conflicts of interest to the
homogeneous time-resolved fluorescence assay. 86 research, authorship, and/or publication of this article.
The selected phytocompounds have demonstrated Author contributions
promising anticancer effects in various cancer therapies.
However, administering these compounds in combination Conceptualization: All authors
with other chemotherapeutic treatments is expected Data curation: Mudiyayirakkani Muthusamy
to yield greater efficacy than using them alone. The Formal analysis: Mudiyayirakkani Muthusamy, Mukesh
synergistic interactions between phytocompounds and Doble
chemotherapeutic medications can enhance the overall Investigation: Mudiyayirakkani Muthusamy, Mukesh
effectiveness of the treatment and reduce the required Doble
dosage of conventional chemotherapeutic drugs. Methodology: Mudiyayirakkani Muthusamy, Mukesh
A combination of these drugs could be used to achieve Doble
better efficacy and effectiveness. Future studies should Project administration: Pratibha Ramani
consider conducting in vitro experiments to analyze the Resources: Pratibha Ramani
effect of these phytocompounds on OSCC. The results Software: Ramya Ramadoss
may contribute significantly to the development and Supervision: Ramya Ramadoss
formulation of natural chemotherapeutic agents that can Validation: Pratibha Ramani, Ramya Ramadoss
be administered alone or as an adjuvant. Visualization: Mudiyayirakkani Muthusamy, Pratibha
Ramani, Ramya Ramadoss
5. Limitations Writing – original draft: Mudiyayirakkani Muthusamy,
Mukesh Doble, Ramya Ramadoss
Although the in silico analysis was conducted Writing – review & editing: Pratibha Ramani
comprehensively, the study has several limitations. The
scoring functions used in molecular docking can produce Ethics approval and consent to participate
inaccurate binding energies. In addition, the restricted
sampling of both ligand and receptor conformations This study was approved by the scientific review board
during pose prediction poses another challenge. Accurately with reference number SRB/PhD/OPATH-2001/22/047.
modeling water molecules in the binding pocket also Consent for publication
remains challenging. Furthermore, the variability in how
docking tools treat the protein can further affect the results. Not applicable.
6. Conclusion Availability of data

This study highlights the potential efficacy of The data used in this work can be made available to the
phytocompounds with anticancer activity. The readers on request to the corresponding author.

Volume 9 Issue 2 (2025) 126 doi: 10.36922/ejmo.7073