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Eurasian Journal of
            Medicine and Oncology                                                 Single-cell sequencing for lung cancer



            Funding                                            5.   Wauthoz N, Rosière R, Amighi K. Inhaled cytotoxic
                                                                  chemotherapy: Clinical challenges, recent developments, and
            This work was  supported by the  National Natural     future prospects. Expert Opin Drug Deliv. 2021;18(3):333-354.
            Science Foundation of China (No.  82200070), the
            Chongqing Wanzhou Municipal Science and Health        doi: 10.1080/17425247.2021.1829590
            Joint Research Project (Grant No. wzwjw-kw2024008),   6.   Otano I, Ucero AC, Zugazagoitia J, Paz-Ares L. At the
            the Chongqing Wanzhou Municipal Science and Health    crossroads of immunotherapy for oncogene-addicted
            Joint Medical Research Project Key Program (Grant No.   subsets of NSCLC. Nat Rev Clin Oncol. 2023;20(3):143-159.
            wzstc-kw2023001), the Innovation and Development Joint      doi: 10.1038/s41571-022-00718-x
            Fund of the Natural Science Foundation of Chongqing (No.   7.   McCoach CE. A  cautionary analysis of immunotherapy
            CSTB2023NSCQ-LMX0037 and No. CSTB2023NSCQ-            prior to targeted therapy. J Thoracic Oncol. 2019;14(1):8-10.
            LMX0038), and the Natural Science Foundation of
            Chongqing, China (No. CSTB2024NSCQ-MSX0761).          doi: 10.1016/j.jtho.2018.10.009
                                                               8.   Cai J, Fang L, Huang Y, et al. Simultaneous overactivation of
            Conflict of interest                                  Wnt/β-catenin and TGFβ signalling by miR-128-3p confers
                                                                  chemoresistance-associated metastasis in NSCLC.  Nat
            The authors declare no conflicts of interest.         Commun. 2017;8:15870.

            Author contributions                                  doi: 10.1038/ncomms15870
            Conceptualization: Mingzhu Yin, Jian Sun           9.   Lambrechts D, Wauters E, Boeckx B, et al. Phenotype molding
            Investigation: Wei Su, Bingbing Bai, Jinhai Deng, Yuesong   of stromal cells in the lung tumor microenvironment. Nat
               Wu                                                 Med. 2018;24(8):1277-1289.
            Writing – original draft: Jian Sun, Zhongsha Li       doi: 10.1038/s41591-018-0096-5
            Writing – review & editing: Wei Su, Bingbing Bai, Yuesong   10.  Altorki NK, Markowitz GJ, Gao D,  et al. The lung
               Wu, Baoyin Zhang, Dejuan Xiang, Gilwa Borjigin,    microenvironment: An important regulator of tumour
               Jinhai Deng                                        growth and metastasis. Nat Rev Cancer. 2019;19(1):9-31.

            Ethics approval and consent to participate            doi: 10.1038/s41568-018-0081-9
                                                               11.  Bischoff P, Trinks A, Obermayer B, et al. Single-cell RNA
            Not applicable.                                       sequencing reveals distinct tumor microenvironmental

            Consent for publication                               patterns  in  lung  adenocarcinoma.  Oncogene.
                                                                  2021;40(50):6748-6758.
            Not applicable.                                       doi: 10.1038/s41388-021-02054-3

            Availability of data                               12.  Tang F, Barbacioru C, Wang Y,  et al. mRNA-Seq whole-
                                                                  transcriptome analysis of a single cell.  Nat Methods.
            Not applicable.                                       2009;6(5):377-382.

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            Volume 9 Issue 2 (2025)                         12                              doi: 10.36922/ejmo.6883
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