Page 20 - EJMO-9-2
P. 20
Eurasian Journal of
Medicine and Oncology Single-cell sequencing for lung cancer
Funding 5. Wauthoz N, Rosière R, Amighi K. Inhaled cytotoxic
chemotherapy: Clinical challenges, recent developments, and
This work was supported by the National Natural future prospects. Expert Opin Drug Deliv. 2021;18(3):333-354.
Science Foundation of China (No. 82200070), the
Chongqing Wanzhou Municipal Science and Health doi: 10.1080/17425247.2021.1829590
Joint Research Project (Grant No. wzwjw-kw2024008), 6. Otano I, Ucero AC, Zugazagoitia J, Paz-Ares L. At the
the Chongqing Wanzhou Municipal Science and Health crossroads of immunotherapy for oncogene-addicted
Joint Medical Research Project Key Program (Grant No. subsets of NSCLC. Nat Rev Clin Oncol. 2023;20(3):143-159.
wzstc-kw2023001), the Innovation and Development Joint doi: 10.1038/s41571-022-00718-x
Fund of the Natural Science Foundation of Chongqing (No. 7. McCoach CE. A cautionary analysis of immunotherapy
CSTB2023NSCQ-LMX0037 and No. CSTB2023NSCQ- prior to targeted therapy. J Thoracic Oncol. 2019;14(1):8-10.
LMX0038), and the Natural Science Foundation of
Chongqing, China (No. CSTB2024NSCQ-MSX0761). doi: 10.1016/j.jtho.2018.10.009
8. Cai J, Fang L, Huang Y, et al. Simultaneous overactivation of
Conflict of interest Wnt/β-catenin and TGFβ signalling by miR-128-3p confers
chemoresistance-associated metastasis in NSCLC. Nat
The authors declare no conflicts of interest. Commun. 2017;8:15870.
Author contributions doi: 10.1038/ncomms15870
Conceptualization: Mingzhu Yin, Jian Sun 9. Lambrechts D, Wauters E, Boeckx B, et al. Phenotype molding
Investigation: Wei Su, Bingbing Bai, Jinhai Deng, Yuesong of stromal cells in the lung tumor microenvironment. Nat
Wu Med. 2018;24(8):1277-1289.
Writing – original draft: Jian Sun, Zhongsha Li doi: 10.1038/s41591-018-0096-5
Writing – review & editing: Wei Su, Bingbing Bai, Yuesong 10. Altorki NK, Markowitz GJ, Gao D, et al. The lung
Wu, Baoyin Zhang, Dejuan Xiang, Gilwa Borjigin, microenvironment: An important regulator of tumour
Jinhai Deng growth and metastasis. Nat Rev Cancer. 2019;19(1):9-31.
Ethics approval and consent to participate doi: 10.1038/s41568-018-0081-9
11. Bischoff P, Trinks A, Obermayer B, et al. Single-cell RNA
Not applicable. sequencing reveals distinct tumor microenvironmental
Consent for publication patterns in lung adenocarcinoma. Oncogene.
2021;40(50):6748-6758.
Not applicable. doi: 10.1038/s41388-021-02054-3
Availability of data 12. Tang F, Barbacioru C, Wang Y, et al. mRNA-Seq whole-
transcriptome analysis of a single cell. Nat Methods.
Not applicable. 2009;6(5):377-382.
References doi: 10.1038/nmeth.1315
13. Navin N, Kendall J, Troge J, et al. Tumour evolution inferred
1. Thai AA, Solomon BJ, Sequist LV, Gainor JF, Heist RS. Lung
cancer. Lancet (London, England). 2021;398(10299):535-554. by single-cell sequencing. Nature. 2011;472(7341):90-94.
doi: 10.1038/nature09807
doi: 10.1016/s0140-6736(21)00312-3
14. Xu X, Hou Y, Yin X, et al. Single-cell exome sequencing
2. Gridelli C, Rossi A, Carbone DP, et al. Non-small-cell lung
cancer. Nat Rev Dis Prim. 2015;1:15009. reveals single-nucleotide mutation characteristics of a
kidney tumor. Cell. 2012;148(5):886-895.
doi: 10.1038/nrdp.2015.9
doi: 10.1016/j.cell.2012.02.025
3. Nooreldeen R, Bach H. Current and future development in 15. Zhang J, Song C, Tian Y, Yang X. Single-cell RNA sequencing
lung cancer diagnosis. In J Mol Sci. 2021;22(16):8661.
in lung cancer: Revealing phenotype shaping of stromal cells
doi: 10.3390/ijms22168661 in the microenvironment. Front Immunol. 2021;12:802080.
4. Li MY, Liu LZ, Dong M. Progress on pivotal role and doi: 10.3389/fimmu.2021.802080
application of exosome in lung cancer carcinogenesis, 16. Yu D, Zhang S, Liu Z, Xu L, Chen L, Xie L. Single-cell RNA
diagnosis, therapy and prognosis. Mol Cancer. 2021;20(1):22.
sequencing analysis of gene regulatory network changes in
doi: 10.1186/s12943-021-01312-y the development of lung adenocarcinoma. Biomolecules.
Volume 9 Issue 2 (2025) 12 doi: 10.36922/ejmo.6883

