Page 25 - EJMO-9-2

Eurasian Journal of Medicine

and Oncology

REVIEW ARTICLE
The role of gut microbiome in obesity and

metabolic dysfunctions: Insights and therapeutic
potential

1
Siham El Moussaoui * , Touria Derkaoui 1,2 , Fatima Zahrae Alaoui Ismaili 1 ,
Nezha Tawfiq 3 , Mohammed El Mzibri 4 , Abdelilah Laraqui 5 ,
1
1,6
Mohamed Mansouri , Amina Barakat , Naima Ghailani Nourouti 1 ,
Maria Paz Weisshaar and Mohcine Bennani Mechita 1
7
1 Intelligent Automation and BioMed Genomics Laboratory, Faculty of Sciences and Techniques of
Tangier, Abdelmalek Essaâdi University, Tétouan, Morocco
2 Higher Institute of Nursing Professions and Health Techniques of Tangier, Ministry of Health,Tangier,
Morocco
3 Mohammed VI Center for Cancer Treatment, Ibn Rochd University Hospital, Hassan II University,
Casablanca, Morocco
4 Biology and Medical Research Unit, National Centre for Energy, Nuclear Sciences and Techniques
(CNESTEN), Rabat, Morocco
5 Sequencing Unit, Center of Virology, Infectious and Tropical Diseases, Mohammed V Military
Teaching Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco
6 Oncology Clinic, Al Amal of Tangier, Morocco
7 Department of Natural Sciences, University of Applied Sciences Bonn-Rhein-Sieg, Rheinbach,
Germany

*Corresponding author:
Siham El Moussaoui
(siham.elmoussaoui1@etu.uae. Abstract
ac.ma)
Citation: El Moussaoui S, Obesity is a chronic inflammatory disease defined by an excessive accumulation of
Derkaoui T, Ismaili FZA, Tawfiq N, body fat. The human gut microbiota (GM) is an intricate ecosystem of microorganisms
El Mzibri M, Laraqui A, et al. The
role of gut microbiome in obesity living symbiotically within the gastrointestinal tract and has emerged as a key player
and metabolic dysfunctions: Insights in health and metabolic diseases. Recently, several studies have increasingly revolved
and therapeutic potential. Eurasian around understanding the specific compositions and strains of GM and their potential
J Med Oncol. 2025;9(2):17-42.
doi: 10.36922/ejmo.8318 impact on obesity. This review provides a summary of the most recent findings
regarding obesity and newly developed therapies that show exceptional efficacy in
Received: December 31, 2024 treating this condition. In addition, it explores different GM strains that may contribute
Revised: January 28, 2025 to the progression and development of obesity. This article summarizes the molecular
Accepted: February 18, 2025 insights involved in the relationship between obesity and GM, the characteristics
of this ecosystem, and its involvement in human metabolism, energy balance, and
Published online: March 24. 2025 inflammation leading to obesity. Furthermore, it examines the bacteria most engaged
Copyright: © 2025 Author(s). in managing obesity. These findings contribute to a better understanding of this
This is an Open Access article significant and intricate relationship, ultimately aiding in obesity prevention.
distributed under the terms of the
Creative Commons Attribution
License, permitting distribution,
and reproduction in any medium, Keywords: Microbiota; Weight loss; Weight gain; Obesity; Diversity; Gut microbiome
provided the original work is
properly cited.
Publisher’s Note: AccScience 1. Introduction
Publishing remains neutral with
regard to jurisdictional claims in
published maps and institutional Obesity is a condition linked to an abnormal accumulation of body fat. It involves
affiliations. various intricate mechanisms. The buildup of fat, a process called adipogenesis, can

Volume 9 Issue 2 (2025) 17 doi: 10.36922/ejmo.8318