Page 262 - EJMO-9-2

Eurasian Journal of
Medicine and Oncology The genetics of chronic stress in cervical lesions

3.1. Analysis using the codominant model 3.2. Analysis using the allelic model

Under the codominant model, we initially compared the For a clearer understanding of the risk or protective effects
distribution of genotypes across HPV-infected individuals of each allele, we examined the allele distribution between
and controls (Table 2). Only significant results are shown. the two populations (Table 3). Only significant results are
Among the genes studied, only SLC6A4 and ADRB2 shown. Notably, ADRB2 (p<0.001) exhibited a distinct
displayed dissimilar genotype distributions between allele distribution, with allele A demonstrating a risk factor
the two female populations (p=0.003 and p<0.001, (OR = 4.091, 95% CI: 2.051 – 8.160).
respectively).
3.3. Analysis using dominant, overdominant, and
recessive models
Table 2. Comparison of genotype distribution using the
codominant model We evaluated the genotype distribution using the
dominant, overdominant, and recessive models (Table 4).
Genes Human papillomavirus, n (%) Controls, n (%) p a
Only genes with significant results are shown. Only for
SLC6A4 significant outcomes were ORs calculated.
12/12 10 (25.6) 219 (44.2) 0.003
12/10 27 (69.2.) 205 (41.4) The genotype distributions varied for the SLC6A4,
10/10 2 (5.1) 71 (14.3) ADRB2, and CHRNA5 genes. In the case of SLC6A4,
the dominant (p=0.024, OR = 2.301, 95% CI: 1.098 –
ADRB2 4.824) and overdominant (p<0.001, OR = 3.183, 95%
GG 2 (6.5) 45 (24.6) <0.001 CI: 1.576 – 6.430) models revealed a risk factor of 10 alleles.
AG 10 (32.3) 93 (50.8) In addition, allele A of ADRB2 emerged as a risk factor, with
AA 19 (61.3) 45 (24.6) two genetic models showing significant results (p=0.024,
Note: Chi-square test, only significant values at p<0.05 are presented. OR = 4.728, 95% CI: 1.085 – 20.603 for the dominant
a
Table 3. Comparison of allele distribution using the allelic model
Gene Human papillomavirus, n (%) Controls, n (%) p a Odds ratio (confidence interval)
ADRB2
Allele G 14 (22.6) 183 (50.0) <0.001 0.244 (0.123 – 0.488)
Allele A 48 (77.4) 183 (50.0) 4.091 (2.051 – 8.160)
Note: Chi-square test, only significant values at p<0.05 are presented.
a

Table 4. Comparison of genotype distribution using the dominant, overdominant, and recessive models
Genes Human papillomavirus, n (%) Controls, n (%) p a Odds ratio (confidence interval)
SLC6A4
10/10 and 12/10 versus 12/12 29 (74.4) 10 (25.6) 276 (55.8) 219 (44.2) 0.024* 2.301 (1.098 – 4.824)
12/10 versus 12/12 and 10/10 27 (69.2) 12 (30.8) 205 (41.4) 290 (58.6) <0.001* 3.183 (1.576 – 6.430)
10/10 versus 12/10and 12/12 2 (5.1) 37 (94.9) 71 (14.3) 424 (85.7) 0.107 NA
ADRB2
AG and AA versus GG 29 (93.5) 2 (6.5) 138 (75.4) 45 (24.6) 0.024* 4.728 (1.085 – 20.603)
AG versus GG and AA 10 (32.3) 21 (67.7) 93 (50.8) 90 (49.2) 0.056 NA
AA versus GG and AG 19 (61.3) 12 (38.7) 45 (24.6) 138 (75.4) <0.001* 4.856 (2.188 – 10.776)
CHRNA5
AG and AA versus GG 32 (50.8) 31 (49.2) 121 (66.1) 62 (33.9) 0.030* 0.529 (0.296 – 0.946)
AG versus GG and AA 21 (33.3) 42 (66.7) 90 (49.2) 93 (50.8) 0.029* 0.517 (0.284 – 0.940)
AA versus AG and GG 11 (17.5) 52 (82.5) 31 (16.9) 152 (83.1) 0.925 NA
Note: Chi-square test, *indicates significance at p<0.05.
a
Abbreviation: NA: Not applicable.

Volume 9 Issue 2 (2025) 254 doi: 10.36922/EJMO025100047