Page 309 - EJMO-9-3

Eurasian Journal of
Medicine and Oncology Ferroptosis inhibition for lung injury treatment

ferroptosis-inhibitory properties. Ganlu Qingwen Fang of traditional Chinese medicine. Chin J Exp Tradit Med
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has been shown to mitigate inflammatory responses and Formul. 2024;30(9):245-253.
oxidative stress in rats, thereby conferring protection doi: 10.13422/j.cnki.syfjx.20232121
against ALI, potentially through the modulation of
the Nrf2/GPX4 ferroptosis pathway. Modified Taoren 3. Chen Z, Tang H, Gan S, et al. Ferroptosis mediates airway
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epithelial E-cadherin dysfunction in LPS-induced acute
Chengqi may ameliorate VILI in rats by activating the lung injury. Pulm Pharmacol Ther. 2024;84:102284.
Nrf2/GPX4 pathway, consequently inhibiting ferroptosis. 8
doi: 10.1016/j.pupt.2023.102284
Ferroptosis represents a promising therapeutic target
for various pulmonary disorders, including ALI, chronic 4. Zhang J, Zheng Y, Wang Y, et al. YAP1 alleviates sepsis-
obstructive pulmonary disease, pulmonary fibrosis, lung induced acute lung injury via inhibiting ferritinophagy-
infections, and asthma, all of which exhibit ferroptosis mediated ferroptosis. Front Immunol. 2022;13:884362.
during their pathogenesis, thereby influencing the doi: 10.3389/fimmu.2022.884362
initiation and progression of the diseases. Thus, future 5. Wang Y, Chen D, Xie H, et al. AUF1 protects against
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investigations should aim to elucidate the specific roles ferroptosis to alleviate sepsis-induced acute lung injury by
of ferroptosis or crosstalk between different cell death regulating NRF2 and ATF3. Cell Mol Life Sci. 2022;79(5):228.
pathways in sepsis-induced ALI and to explore their
comprehensive signaling pathways and correlation with doi: 10.1007/s00018-022-04248-8
disease prognosis. Such research endeavors hold the 6. Li C, Wang H, He Q, Guo X, Jiang T, Guo Y. Study on
potential to unveil novel therapeutic targets and strategies the effect and mechanism of quercetin in inhibiting the
for the management of ALI. proliferation of A549 cells by inducing ferroptosis. Chin
Herb Med. 2022;53(22):7112-7120.
Funding 7. Li J, Li Z, Li X, Liang Q, Liao C, Li F. Exploration of the
The Science & Technology Development Fund of Tianjin protective effect of Ganlu Qingwen formula on rats with
Education Commission for Higher Education (2023KJ131). acute lung injury based on the Nrf2/GPX4 ferroptosis
pathway. ZCY. 2024;47(2):596-600.
Conflict of interest 8. Sun Z, Wang L, Suo H, Li H, Chen Q. Exploration of the

The authors declare no competing interests. protective effect of jiawei taoren chengqi decoction on rats
with ventilator-associated lung injury based on the Nrf2/
References GPX4 ferroptosis pathway. Tradit Chin Drug Res Clin
Pharmacol. 2024;35(9):1281-1288.
1. Zhao L, Ge G, Li J, Han X. The improvement effect of
osthole on lung injury in rats with mycoplasma pneumoniae doi: 10.19378/j.issn.1003-9783.2024.09.001
pneumonia through the Nrf2-Gpx4 ferroptosis pathway. 9. Zhao L, Ge G, Li J, Han X. The improvement effect of
ZCY. 2023;45(1):48-54. osthole on lung injury in rats with mycoplasma pneumoniae
2. Zhang H, Zhang Y, Fu J, et al. Research progress on the pneumonia through the Nrf2-Gpx4 ferroptosis pathway.
induction of ferroptosis in tumor cells by active ingredients ZCY. 2023;45(1):48-54.

Volume 9 Issue 3 (2025) 301 doi: 10.36922/EJMO025090043