Page 122 - GPD-1-2

Gene & Protein in Disease Exosomes connect periodontitis and systemic diseases

155-5p from PDLSCs regulated Th17/Treg balance by which Porphyromonas gingivalis evades innate immunity.
targeting sirtuin-1 in chronic periodontitis. J Cell Physiol, PLoS One, 12(8): e0182164.
234(11): 20662–20674.
https://doi.org/10.1371/journal.pone.0182164
https://doi.org/10.1002/jcp.28671
101. Sun W, Zhao C, Li Y, et al., 2016, Osteoclast-derived
90. Herbert BA, Novince CM, Kirkwood KL, 2016, microRNA-containing exosomes selectively inhibit
Aggregatibacter actinomycetemcomitans, a potent osteoblast activity. Cell Discov, 2: 16015.
immunoregulator of the periodontal host defense system https://doi.org/10.1038/celldisc.2016.15
and alveolar bone homeostasis. Mol Oral Microbiol, 31(3):
207–227. 102. Chunhui HU, Yinghua LI, Zhi Q, et al., 2019, Proteomics
analysis of serum exosomes and its application in
https://doi.org/10.1111/omi.12119 osteoporosis. Chin J Chromatogr, 37(8): 863–871.
91. Han EC, Choi SY, Lee Y, et al., 2019, Extracellular RNAs in 103. Wang Z, Sun D, 2018, Adipose-derived mesenchymal stem
periodontopathogenic outer membrane vesicles promote cells: A new tool for the treatment of renal fibrosis. Stem
TNF-α production in human macrophages and cross the Cells Dev, 27(20): 1406–1411.
blood-brain barrier in mice. FASEB J, 33(12): 13412–13422.
https://doi.org/10.1089/scd.2017.0304
https://doi.org/10.1096/fj.201901575r
104. Zhao T, Sun F, Liu J, et al., 2019, Emerging role of
92. Yu J, Lin Y, Xiong X, et al., 2019, Detection of exosomal mesenchymal stem cell-derived exosomes in regenerative
PD-L1 RNA in saliva of patients with periodontitis. Front medicine. Curr Stem Cell Res Ther, 14(6): 482–494.
Genet, 10: 202.
https://doi.org/10.2174/1574888x14666190228103230
https://doi.org/10.3389/fgene.2019.00202
105. Nogueira A, Pires MJ, Oliveira PA, 2017,
93. Huang X, Hu X, Zhao M, et al., 2020, Analysis of salivary Pathophysiological mechanisms of renal fibrosis:
exosomal proteins in young adults with severe periodontitis. A review of animal models and therapeutic strategies. In
Oral Dis, 26(1): 173–181. Vivo (Athens, Greece), 31(1): 1–22.
https://doi.org/10.1111/odi.13217 https://doi.org/10.21873/invivo.11019
94. Brosseau C, Colas L, Magnan A, et al., 2018, CD9 tetraspanin: 106. Meng XM, Inflammatory mediators and renal fibrosis. Adv
A new pathway for the regulation of inflammation? Front Exp Med Biol, 1165: 381–406.
Immunol, 9: 2316.
107. Berchtold L, Friedli I, Vallée JP, et al., 2017, Diagnosis and
https://doi.org/10.3389/fimmu.2018.02316 assessment of renal fibrosis: The state of the art. Swiss Med
95. Zhao LR, Mao JQ, Zhao BJ, et al., 2019, Isolation and Wkly, 147: w14442.
biological characteristics of exosomes derived from https://doi.org/10.4414/smw.2017.14442
periodontal ligament stem cells. Shanghai Kou Qiang Yi Xue,
28(4): 343–348. 108. Khalaf H, Lönn J, Bengtsson T, 2014, Cytokines and
chemokines are differentially expressed in patients with
96. Zhao M, Dai W, Wang H, et al., 2019, Periodontal ligament periodontitis: Possible role for TGF-β1 as a marker for
fibroblasts regulate osteoblasts by exosome secretion induced disease progression. Cytokine, 67(1): 29–35.
by inflammatory stimuli. Arch Oral Biol, 105: 27–34.
https://doi.org/10.1016/j.cyto.2014.02.007
https://doi.org/10.1016/j.archoralbio.2019.06.002
109. Meng XM, Nikolic-Paterson DJ, Lan HY, 2016, TGF-β:
97. Papadopoulos G, Kramer CD, Slocum CS, et al., 2014, A The master regulator of fibrosis. Nat Rev Nephrol, 12(6):
mouse model for pathogen-induced chronic inflammation 325–338.
at local and systemic sites. J Vis Exp, 90: e51556.
https://doi.org/10.1038/nrneph.2016.48
https://doi.org/10.3791/51556
110. Ma TT, Meng XM, 2019, TGF-β/smad and renal fibrosis.
98. Wang M, Li J, Ye Y, et al., 2020, SHED-derived conditioned Adv Exp Med Biol, 1165: 347–364.
exosomes enhance the osteogenic differentiation of PDLSCs 111. Chen P, Xuan DY, Zhang JC, 2017, Periodontitis aggravates
via Wnt and BMP signaling in vitro. Differentiation, kidney damage in obese mice by MMP2 regulation. Bratisl
111: 1–11.
Lek Listy, 118(12): 740–745.
https://doi.org/10.1016/j.diff.2019.10.003
https://doi.org/10.4149/bll_2017_140
99. Straka M, Straka-Trapezanlidis M, Deglovic J, et al., 2015, 112. Borges FT, Melo SA, Özdemir BC, et al, 2013, TGF-β1-
Periodontitis and osteoporosis. Neuroendocrinol Lett, containing exosomes from injured epithelial cells activate
36(5): 401–406. fibroblasts to initiate tissue regenerative responses and
100. Abdi K, Chen T, Klein BA, et al., 2017, Mechanisms by fibrosis. J Am Soc Nephrol, 24(3): 385–392.

Volume 1 Issue 2 (2022) 15 https://doi.org/10.36922/gpd.v1i2.99