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Gene & Protein in Disease lncRNAs in trained immunity

aerobic glycolysis, forming the metabolic foundation of Ethics approval and consent to participate
trained immunity. Increased glycolysis and tricarboxylic
19
acid cycle intermediates, such as fumarate and glutamate, Not applicable.
regulate the methylation (H3K4me3) and acetylation (lysine Consent for publication
27 acetylation, H3K27ac) of histones, highlighting the
91
metabolic basis of trained immunity. BCG-induced trained Not applicable.
immunity is also an example of metabolic reprogramming, Availability of data
in which a shift in glucose metabolism to glycolysis is
required for histone modification to occur. 92 Not applicable.
4. Conclusion References
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Harnessing the functions of lncRNAs offers a promising
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may lead to the development of targeted interventions and
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Acknowledgments 2015;47(3):199-208.
None. doi: 10.1038/ng.3192
Funding 8. Ahmad I, Valverde A, Ahmad F, Naqvi AR. Long noncoding
RNA in myeloid and lymphoid cell differentiation,
None. polarization and function. Cells. 2020;9(2):269.
Conflict of interest doi: 10.3390/cells9020269
9. Matsui M, Corey DR. Non-coding RNAs as drug targets.
The authors declare that they have no competing interests.
Nat Rev Drug Discov. 2017;16(3):167-179.
Author contributions doi: 10.1038/nrd.2016.117
Conceptualization: Bikesh Kumar Nirala, Praveen Kumar, 10. Yi K, Zhang Y, Wang Y, et al. Long noncoding RNA and
Ravi Shankar Singh its role in virus infection and pathogenesis. Front Biosci
Writing ‑original draft: All authors (Landmark Ed). 2019;24:777-789.
Writing ‑review & editing: All authors doi: 10.2741/4750

Volume 3 Issue 2 (2024) 11 doi: 10.36922/gpd.2791