Page 21 - GPD-3-2

Gene & Protein in Disease lncRNAs in trained immunity

2018;19(2):570. maintains active chromatin to coordinate homeotic gene
expression. Nature. 2011;472(7341):120-124.
doi: 10.3390/ijms19020570
doi: 10.1038/nature09819
75. Kanbar JN, Ma S, Kim ES, et al. The long noncoding RNA
Malat1 regulates CD8+ T cell differentiation by mediating 85. Gomez JA, Wapinski OL, Yang YW, et al. The NeST long
epigenetic repression. J Exp Med. 2022;219(6):e20211756. ncRNA controls microbial susceptibility and epigenetic
doi: 10.1084/jem.20211756 activation of the interferon-γ locus. Cell. 2013;152(4):743-754.
76. Fok ET, Davignon L, Fanucchi S, Mhlanga MM. The lncRNA doi: 10.1016/j.cell.2013.01.015
connection between cellular metabolism and epigenetics in 86. Murphy MB, Medvedev AE. Long noncoding RNAs
trained immunity. Front Immunol. 2018;9:3184. as regulators of Toll-like receptor signaling and innate
doi: 10.3389/fimmu.2018.03184 immunity. J Leukoc Biol. 2016;99(6):839-850.
77. Fanucchi S, Dominguez-Andres J, Joosten LA, Netea MG, doi: 10.1189/jlb.2RU1215-575R
Mhlanga MM. The Intersection of epigenetics and 87. Carpenter S. Long noncoding RNA: Novel links between
metabolism in trained immunity. Immunity. 2021;54(1): gene expression and innate immunity. Virus Res.
32-43. 2016;212:137-145.
doi: 10.1016/j.immuni.2020.10.011 doi: 10.1016/j.virusres.2015.08.019
78. Fernandes JC, Acuna SM, Aoki JI, Floeter-Winter LM, 88. Du M, Yuan L, Tan X, et al. The LPS-inducible lncRNA
Muxel SM. Long Non-Coding RNAs in the regulation of Mirt2 is a negative regulator of inflammation. Nat Commun.
gene expression: Physiology and disease. Noncoding RNA. 2017;8(1):2049.
2019;5(1):17.
doi: 10.1038/s41467-017-02229-1
doi: 10.3390/ncrna5010017
89. Lu W, Cao F, Wang S, Sheng X, Ma J. LncRNAs: The regulator
79. Zhang T, Cooper S, Brockdorff N. The interplay of glucose and lipid metabolism in tumor cells. Front Oncol.
of histone modifications-writers that read. EMBO 2019;9:1099.
Rep. 2015;16(11):1467-1481.
doi: 10.3389/fonc.2019.01099
doi: 10.15252/embr.201540945
90. Hong J, Guo F, Lu SY, et al. F. nucleatum targets lncRNA
80. Bohmdorfer G, Wierzbicki AT. Control of chromatin ENO1-IT1 to promote glycolysis and oncogenesis in
structure by long noncoding RNA. Trends Cell Biol. colorectal cancer. Gut. 2021;70(11):2123-2137.
2015;25(10):623-632.
doi: 10.1136/gutjnl-2020-322780
doi: 10.1016/j.tcb.2015.07.002
91. Sohrabi Y, Godfrey R, Findeisen HM. Altered cellular
81. Fanucchi S, Fok ET, Dalla E, et al. Immune genes are primed metabolism drives trained immunity. Trends Endocrinol
for robust transcription by proximal long noncoding RNAs Metab. 2018;29(9):602-605.
located in nuclear compartments. Nat Genet. 2019;51(1):
138-150. doi: 10.1016/j.tem.2018.03.012
doi: 10.1038/s41588-018-0298-2 92. Arts RJ, Carvalho A, La Rocca C, et al. Immunometabolic
pathways in BCG-induced trained immunity. Cell
82. Fanucchi S, Mhlanga MM. Lnc-ing trained immunity to Rep. 2016;17(10):2562-2571.
chromatin architecture. Front Cell Dev Biol. 2019;7:2.
doi: 10.1016/j.celrep.2016.11.011
doi: 10.3389/fcell.2019.00002
93. Sohrabi Y, Dos Santos JC, Dorenkamp M, et al. Trained
83. Kim TK, Hemberg M, Gray JM. Enhancer RNAs: A class of immunity as a novel approach against COVID-19 with a
long noncoding RNAs synthesized at enhancers. Cold Spring focus on Bacillus Calmette-Guérin vaccine: Mechanisms,
Harb Perspect Biol. 2015;7(1):a018622.
challenges and perspectives. Clin Transl Immunol.
doi: 10.1101/cshperspect.a018622 2020;9(12):e1228.
84. Wang KC, Yang YW, Liu B, et al. A long noncoding RNA doi: 10.1002/cti2.1228

Volume 3 Issue 2 (2024) 15 doi: 10.36922/gpd.2791