Page 137 - GPD-3-3

Gene & Protein in Disease Association of GST1 with lung cancer

Methodology: Arpan Saha, Madhurima Sinha, Susweta Roy accessed on 2024 Sep 23].
Resources: Somsubhra Nath 7. Byun J, Han Y, Li Y, et al. Cross-ancestry genome-wide meta-
Writing – original draft: Arpan Saha analysis of 61,047 cases and 947,237 controls identifies new
Writing – review & editing: Mainak Sengupta susceptibility loci contributing to lung cancer. Nat Genet.
2022;54(8):1167-1177.
Ethics approval and consent to participate
doi: 10.1038/s41588-022-01115-x
The study protocol involving human subjects was approved 8. Sato M, Shames DS, Gazdar AF, Minna JD. A translational
by the Ethics Committee of Saroj Gupta Cancer Centre and view of the molecular pathogenesis of lung cancer. J Thorac
Research Institute (IEC SGCCRI Ref No-2017/MS/1; dated: Oncol. 2007;2(4):327-343.
October 11, 2017), the Ethics Committee of IPGME&R doi: 10.1097/01.JTO.0000263718.69320.4c
(Memo No. Inst/IEC/2015/545; dated: December 10,
2015), and the Ethics Committee of the University of 9. Sun S, Schiller JH, Spinola M, Minna JD. New molecularly
Calcutta (Ref No: 0024/16-117/1434; dated: October targeted therapies for lung cancer. J Clin Invest.
24, 2016) in Kolkata, India. The approval was granted in 2007;117(10):2740-2750.
accordance with the regulations of the Indian Council of doi: 10.1172/JCI31809
Medical Research (ICMR) and followed the Declaration 10. Long E, Patel H, Byun J, Amos CI, Choi J. Functional studies
of Helsinki, 1964. Informed consent was obtained from all of lung cancer GWAS beyond association. Hum Mol Genet.
individual participants included in the study. 2022;31(R1):R22-R36.

Consent for publication doi: 10.1093/hmg/ddac140
11. Van Dyck E, Nazarov PV, Muller A, et al. Bronchial airway
The study subjects gave consent to publish their data.
gene expression in smokers with lung or head and neck
Availability of data cancer. Cancer Med. 2014;3(2):322-336.
doi: 10.1002/cam4.190
All data generated or analyzed during this study are
available from the corresponding author on reasonable 12. Hammouz RY, Kostanek JK, Dudzisz A, Witas P,
request. Orzechowska M, Bednarek AK. Differential expression
of lung adenocarcinoma transcriptome with signature of
References tobacco exposure. J Appl Genet. 2020;61(3):421-437.
1. Singh N, Agrawal S, Jiwnani S, et al. Lung cancer in India. doi: 10.1007/s13353-020-00569-1
J Thorac Oncol. 2021;16(8):1250-1266. 13. Bozhilov YK, Downes DJ, Telenius J, et al. A gain-of-
doi: 10.1016/j.jtho.2021.02.004 function single nucleotide variant creates a new promoter
which acts as an orientation-dependent enhancer-blocker.
2. United States. Public Health Service. Office of the Surgeon Nat Commun. 2021;12(1):3806.
General. How Tobacco Smoke Causes Disease : The Biology
and Behavioral Basis for Smoking-Attributable Disease : doi: 10.1038/s41467-021-23980-6
A Report of the Surgeon General. U.S: Department of Health 14. Kotnis A, Sarin R, Mulherkar R. Genotype, phenotype and
and Human Services, Public Health Service, Office of the cancer: Role of low penetrance genes and environment in
Surgeon General; 2010. tumour susceptibility. J Biosci. 2005;30:93-102.
3. Department of Health and Human Services. The Health doi: 10.1007/BF02705154
Consequences of Smoking - 50 Years of Progress: A Report of
the Surgeon General. Available from: https://www.cdc.gov/ 15. Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N,
tobacco [Last accessed on 2024 Sep 23]. Hecht SS, Hainaut P. Tobacco smoke carcinogens, DNA
damage and p53 mutations in smoking-associated cancers.
4. Mathur P, Sathishkumar K, Chaturvedi M, et al. Cancer Oncogene. 2002;21:7435-7451.
Statistics, 2020: Report from national cancer registry
programme, India. JCO Glob Oncol. 2020;6:1063-1075. doi: 10.1038/sj.onc.1205803
16. Leanderson P, Tagesson C. Cigarette smoke-induced DNA
doi: 10.1200/GO.20.00122
damage in cultured human lung cells: Role of hydroxyl
5. Schwartz AG. Genetic epidemiology of cigarette smoke- radicals and endonuclease activation. Chem Biol Interact.
induced lung disease. Proc Am Thorac Soc. 2012;9:22-26. 1992;81:197-208.
doi: 10.1513/pats.201106-037MS doi: 10.1016/0009-2797(92)90034-i
6. Ankathil R. Tobacco, Genetic Susceptibility and Lung Cancer. 17. Sengupta D, Mukhopadhyay P, Banerjee S, et al. Identifying
Vol. 2010. Available from: https://www.la-press.com [Last polymorphic cis-regulatory variants as risk markers for lung

Volume 3 Issue 3 (2024) 7 doi: 10.36922/gpd.3928