Page 17 - GPD-3-4

Gene & Protein in Disease Human sirtuins (SIRT1-7) in cancer

Front Immunol. 2023;14:1174180. doi: 10.1016/j.arr.2019.100961
doi: 10.3389/fimmu.2023.1174180 24. Maxwell MM, Tomkinson EM, Nobles J, et al. The Sirtuin
2 microtubule deacetylase is an abundant neuronal protein
12. Chen G, Huang P, Hu C. The role of SIRT2 in cancer: A novel that accumulates in the aging CNS. Hum Mol Genet.
therapeutic target. Int J Cancer. 2020;147(12):3297-3304.
2011;20:3986-3996.
doi: 10.1002/ijc.33118
doi: 10.1093/hmg/ddr326
13. Mishra Y, Kaundal RK. Role of SIRT3 in mitochondrial 25. Mei Z, Zhang X, Yi J, Huang J, He J, Tao Y. Sirtuins in
biology and its therapeutic implications in neurodegenerative metabolism, DNA repair and cancer. J Exp Clin Cancer Res.
disorders. Drug Discov Today. 2023;28(6):103583.
2016;35:182.
doi: 10.1016/j.drudis.2023.103583
doi: 10.1186/s13046-016-0461-5
14. Li Y, Zhou Y, Wang F, et al. SIRT4 is the last puzzle of mitochondrial 26. Diao Z, Ji Q, Wu Z, et al. SIRT3 consolidates heterochromatin and
sirtuins. Bioorg Med Chem. 2018;26(14):3861-3865. counteracts senescence. Nucleic Acids Res. 2021;49:4203-4219.
doi: 10.1016/j.bmc.2018.07.031
doi: 10.1093/nar/gkab161
15. Wang Y, Chen H, Zha X. Overview of SIRT5 as a potential 27. Wang Q, Li L, Li CY, Pei Z, Zhou M, Li N. SIRT3 protects
therapeutic target: Structure, function and inhibitors. Eur J cells from hypoxia via PGC-1α- and MnSOD-dependent
Med Chem. 2022;236:114363.
pathways. Neuroscience. 2015;286:109-121.
doi: 10.1016/j.ejmech.2022.114363 doi: 10.1016/j.neuroscience.2014.11.045
16. Yang Y, Zhu M, Liang J, et al. SIRT6 mediates 28. Zhang J, Xiang H, Liu J, Chen Y, He RR, Liu B. Mitochondrial
multidimensional modulation to maintain organism sirtuin 3: New emerging biological function and therapeutic
homeostasis. J Cell Physiol. 2022;237(8):3205-3221. target. Theranostics. 2020;10:8315-8342.
doi: 10.1002/jcp.30791 doi: 10.7150/thno.45922
17. Raza U, Tang X, Liu Z, Liu B. SIRT7: The seventh key to unlocking 29. Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5
the mystery of aging. Physiol Rev. 2024;104(1):253-280. Deacetylates carbamoyl phosphate synthetase 1 and
doi: 10.1152/physrev.00044.2022 regulates the urea cycle. Cell. 2009;137:560-570.
18. Alves-Fernandes DK, Jasiulionis MG. The role of SIRT1 on doi: 10.1016/j.cell.2009.02.026
DNA damage response and epigenetic alterations in cancer. 30. Matsushita N, Yonashiro R, Ogata Y, et al. Distinct regulation
Int J Mol Sci. 2019;20(13):3153. of mitochondrial localization and stability of two human
doi: 10.3390/ijms20133153 Sirt5 isoforms. Genes Cells. 2011;16:190-202.
19. Singh V, Ubaid S. Role of silent information regulator 1 doi: 10.1111/j.1365-2443.2010.01475.x
(SIRT1) in regulating oxidative stress and inflammation. 31. Kumar S, Lombard DB. Functions of the sirtuin deacylase
Inflammation. 2020;43:1589-1598. SIRT5 in normal physiology and pathobiology. Crit Rev
doi: 10.1007/s10753-020-01242-9 Biochem Mol Biol. 2018;53:311-334.
20. Lin L, Guo Z, He E, et al. SIRT2 regulates extracellular doi: 10.1080/10409238.2018.1458071
vesicle-mediated liver-bone communication. Nat Metab. 32. Wang YQ, Wang HL, Xu J, et al. Sirtuin5 contributes to
2023;5:821-841. colorectal carcinogenesis by enhancing glutaminolysis
doi: 10.1038/s42255-023-00803-0 in a deglutarylation-dependent manner. Nat Commun.
2018;9:545.
21. Rack JGM, VanLinden MR, Lutter T, Aasland R, Ziegler M.
Constitutive nuclear localization of an alternatively spliced doi: 10.1038/s41467-018-02951-4
sirtuin-2 isoform. J Mol Biol. 2014;426:1677-1691. 33. Chang AR, Ferrer CM, Mostoslavsky R. SIRT6, a
doi: 10.1016/j.jmb.2013.10.027 mammalian deacylase with multitasking abilities. Physiol
Rev. 2020;100:145-169.
22. Inoue T, Hiratsuka M, Osaki M, Oshimura M. The molecular
biology of mammalian SIRT proteins: SIRT2 in cell cycle doi: 10.1152/physrev.00030.2018
regulation. Cell Cycle. 2007;6:1011-1018. 34. Liu G, Chen H, Liu H, Zhang W, Zhou J. Emerging roles of
doi: 10.4161/cc.6.9.4219 SIRT6 in human diseases and its modulators. Med Res Rev.
2021;41:1089-1137.
23. Wang Y, Yang J, Hong T, Chen X, Cui L. SIRT2: Controversy
and multiple roles in disease and physiology. Ageing Res Rev. doi: 10.1002/med.21753
2019;55:100961. 35. Lagunas-Rangel FA. SIRT7 in the aging process. Cell Mol

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