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Gene & Protein in Disease Identification of new genes

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patterns and mutations that might be missed by traditional breast and ovarian cancer: New genes in confined pathways.
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biological pathways, revealing interconnected networks Programme. Nat Med. 2024;30:279-289.
of genes and proteins involved in cancer. This holistic doi: 10.1038/s41591-023-02682-0
view aids in understanding underlying mechanisms
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suggest existing drugs for repurposing based on their Mutational signatures: Emerging concepts, caveats and
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Despite their relevance, AI-based findings should
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Collaboration among researchers, access to comprehensive multiple mutations within individual oncogenes. Nature.
databases, advanced technologies, and integration of 2020;582:95-99.
multiple approaches can lead to the identification of new doi: 10.1038/s41586-020-2175-2
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Nature. 2023;623:432-441.
Conflict of interest doi: 10.1038/s41586-023-06682-5

Amancio Carnero is an Associate Editor of this journal. 10. Eifert C, Powers RS. From cancer genomes to oncogenic
drivers, tumour dependencies and therapeutic targets. Nat
Further disclosure Rev Cancer. 2012;12:572-578.

There are tens of thousands of works describing techniques doi: 10.1038/nrc3299
to identify new genes involved in cancer. It would have 11. Katti A, Diaz BJ, Caragine CM, Sanjana NE, Dow LE.
been impossible to cite all of them, even citations of only CRISPR in cancer biology and therapy. Nat Rev Cancer.
some landmark works using every technique. Therefore, 2022;22:259-279.
we only suggest further reading on the same topic and the doi: 10.1038/s41568-022-00441-w
references listed in this editorial for a better understanding.
12. Paczkowska M, Barenboim J, Sintupisut N, et al. Integrative
References pathway enrichment analysis of multivariate omics data. Nat
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Volume 4 Issue 1 (2025) 2 doi: 10.36922/gpd.2892