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Gene & Protein in Disease Prognostic role of SIRT1 expression in cancer

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also pave the way for more effective cancer management 2. McBurney MW, Clark-Knowles KV, Caron AZ, Gray DA.
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Acknowledgment 2013;4(3-4):125-134.
The authors wish to thank the Vice Chancellor of the doi: 10.1177/1947601912474893
University of Narowal for providing support for this study.
3. Luo J, Nikolaev AY, Imai SI, et al. Negative control of
Funding p53 by Sir2α promotes cell survival under stress. Cell.
2001;107(2):137-148.
None.
doi: 10.1016/s0092-8674(01)00524-4
Conflict of interest 4. Wang RH, Sengupta K, Li C, et al. Impaired DNA damage
Umair Ali Khan Saddozai and Xin-Ying Ji are members of response, genome instability, and tumorigenesis in SIRT1
mutant mice. Cancer Cell. 2008;14(4):312-323.
the Editorial Board of this journal but were not involved in
the editorial and peer-review processes for this paper, either doi: 10.1016/j.ccr.2008.09.001
directly or indirectly. Separately, the other authors declare 5. Khawar MB, Sohail AM, Li W. SIRT1: A key player in male
that they have no known competing financial interests or reproduction. Life. 2022;12(2):318.
personal relationships that could have influenced the work doi: 10.3390/life12020318
reported in this paper.
6. Khawar MB, Liu C, Gao F, et al. Sirt1 regulates testosterone
Author contributions biosynthesis in Leydig cells via modulating autophagy.
Protein Cell. 2021;12(1):67-75.
Conceptualization: Muhammad Babar Khawar, Xin-Ying Ji
Data curation: Ali Afzal, Muhammad Babar Khawar, doi: 10.1007/s13238-020-00771-1
Sana Tanveer, Mehreen Iftikhar, Shaaf Ahmad, Amna 7. Wang XW, Jiang YH, Ye W, Shao CF, Xie JJ, Li X. SIRT1
Rehman promotes the progression and chemoresistance of colorectal
Formal analysis: Ali Afzal, Muhammad Babar Khawar, cancer through the p53/miR-101/KPNA3 axis. Cancer Biol
Samyyia Abrar, Faiqa Irshad, Kaleem Maqsood, Ther. 2023;24(1):2235770.
Umair Ali Khan Saddozai, Xin-Ying Ji doi: 10.1080/15384047.2023.2235770
Investigation: Muhammad Babar Khawar, Xin-Ying Ji
Methodology: Ali Afzal, Muhammad Babar Khawar, 8. Carafa V, Altucci L, Nebbioso A. Dual tumor suppressor and
Sana Tanveer, Mehreen Iftikhar, Shaaf Ahmad, tumor promoter action of sirtuins in determining malignant
Amna Rehman phenotype. Front Pharmacol. 2019;10:38.
Writing – original draft: Ali Afzal, Muhammad Babar, doi: 10.3389/fphar.2019.00038
Khawar, Sana Tanveer, Mehreen Iftikhar, Shaaf, 9. Alves-Fernandes DK, Jasiulionis MG. The role of SIRT1 on
Ahmad, Amna Rehman DNA damage response and epigenetic alterations in cancer.
Writing – review & editing: Ali Afzal, Muhammad Babar Int J Mol Sci. 2019;20(13):3153.
Khawar, Sana Tanveer, Mehreen Iftikhar
doi: 10.3390/ijms20133153
Ethics approval and consent to participate 10. Karbasforooshan H, Roohbakhsh A, Karimi G. SIRT1 and
microRNAs: The role in breast, lung and prostate cancers.
Not applicable.
Exp Cell Res. 2018;367(1):1-6.
Consent for publication doi: 10.1016/j.yexcr.2018.03.023

Not applicable. 11. Shuang T, Wang M, Zhou Y, Shi C. Over-expression of
Sirt1 contributes to chemoresistance and indicates poor
Availability of data prognosis in serous epithelial ovarian cancer (EOC). Med
Oncol. 2015;32:260.
Not applicable.
doi: 10.1007/s12032-015-0706-8
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1. Kumar A, Chauhan S. How much successful are the is associated with a poor prognosis, whereas DBC1 is
medicinal chemists in modulation of SIRT1: A critical associated with favorable outcomes in gastric cancer. Cancer
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