Page 46 - GPD-4-1
P. 46
Gene & Protein in Disease GPER1 in brain and heart diseases
7. Paterni I, Granchi C, Katzenellenbogen JA, Minutolo F. cytokeratin intermediate filaments. Mol Pharmacol.
Estrogen receptors alpha (ERα) and beta (ERβ): subtype- 2011;79(3):400-410.
selective ligands and clinical potential. Steroids. 2014;90:13-29.
doi: 10.1124/mol.110.069500.
doi: 10.1016/j.steroids.2014.06.012
17. Cheng SB, Quinn JA, Graeber CT, Filardo EJ. Down-
8. Filardo EJ, Quinn JA, Frackelton AR Jr., Bland KI. Estrogen modulation of the G-protein-coupled estrogen receptor,
action via the G protein-coupled receptor, GPR30: GPER, from the cell surface occurs via a trans-Golgi-
Stimulation of adenylyl cyclase and cAMP-mediated proteasome pathway. J Biol Chem. 2011;286(25):22441-22455.
attenuation of the epidermal growth factor receptor-to-
MAPK signaling axis. Mol Endocrinol. 2002;16(1):70-84. doi: 10.1074/jbc.M111.224071
doi: 10.1210/mend.16.1.0758 18. Gonzalez de Valdivia E, Broselid S, Kahn R, Olde B, Leeb-
Lundberg LMF. G protein-coupled estrogen receptor 1
9. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, (GPER1)/GPR30 increases ERK1/2 activity through PDZ
Prossnitz ER. A transmembrane intracellular estrogen motif-dependent and-independent mechanisms. J Biol
receptor mediates rapid cell signaling. Science. Chem. 2017;292(24):9932-9943.
2005;307(5715):1625-1630.
doi: 10.1074/jbc.M116.765875
doi: 10.1126/science.1106943
19. Filardo EJ. Epidermal growth factor receptor (EGFR)
10. Thomas P, Pang Y, Filardo EJ, Dong J. Identity of an estrogen transactivation by estrogen via the G-protein-coupled
membrane receptor coupled to a G protein in human breast receptor, GPR30: A novel signaling pathway with potential
cancer cells. Endocrinology. 2005;146(2):624-632. significance for breast cancer. J Steroid Biochem Mol Biol.
doi: 10.1210/en.2004-1064 2002;80(2):231-238.
11. Gonzalez de Valdivia E, Sandén C, Kahn R, Olde B, Leeb- doi: 10.1016/S0960-0760(01)00190-X
Lundberg LMF. Human G protein-coupled receptor 30 20. Ding X, Gao T, Gao P, et al. Activation of the G protein-
is N-glycosylated and N-terminal domain asparagine coupled estrogen receptor elicits store calcium release and
44 is required for receptor structure and activity. Biosci phosphorylation of the Mu-opioid receptors in the human
Rep. 2019;39(2):BSR20182436.
neuroblastoma SH-SY5Y cells. Front Neurosci. 2019;13:1351.
doi: 10.1042/BSR20182436
doi: 10.3389/fnins.2019.01351
12. Luo J, Liu D. Does GPER really function as a G protein- 21. Chuang SC, Chen CH, Chou YS., Ho ML, Chang JK.
coupled estrogen receptor in vivo? Front Endocrinol. G protein-coupled estrogen receptor mediates cell
2020;11:148.
proliferation through the cAMP/PKA/CREB pathway in
doi: 10.3389/fendo.2020.00148 murine bone marrow mesenchymal stem cells. Int J Mol Sci.
13. Sakamoto H, Matsuda KI, Hosokawa K, et al. Expression 2020;21(18):6490.
of G protein-coupled receptor-30, a G protein-coupled doi: 10.3390/ijms21186490
membrane estrogen receptor, in oxytocin neurons of the
rat paraventricular and supraoptic nuclei. Endocrinology. 22. Conde K, Meza C, Kelly MJ, Sinchak K, Wagner EJ. Estradiol
2007;148(12):5842-5850. rapidly attenuates ORL-1 receptor-mediated inhibition of
proopiomelanocortin neurons via Gq-coupled, membrane-
doi: 10.1210/en.2007-0436 initiated signaling. Neuroendocrinology. 2016;103(6):787-805.
14. Warfvinge K, Krause DN, Maddahi A, Edvinsson JCA, doi: 10.1159/000443765
Edvinsson L, Haanes KA. Estrogen receptors α, β and
GPER in the CNS and trigeminal system - molecular and 23. Ahmadian Elmi M, Motamed N, Picard D. Proteomic
functional aspects. J Headache Pain. 2020;21(1):131. analyses of the G protein-coupled estrogen receptor
GPER1 reveal constitutive links to endoplasmic reticulum,
doi: 10.1186/s10194-020-01197-0 glycosylation, trafficking, and calcium signaling. Cells.
15. Goncalves GK, Scalzo S, Alves AP, Agero U, Guatimosim S, 2023;12(21):2571.
Reis AM. Neonatal cardiomyocyte hypertrophy induced doi: 10.3390/cells12212571
by endothelin-1 is blocked by estradiol acting on GPER.
American journal of physiology. Am J Physiol Cell Physiol. 24. Tutzauer J, Serafin DS, Schmidt T, Olde B, Caron KM,
2018;314(3):C310-C322. Leeb-Lundberg LMF. G protein-coupled estrogen receptor
(GPER)/GPR30 forms a complex with the β1-adrenergic
doi: 10.1152/ajpcell.00060.2017 receptor, a membrane-associated guanylate kinase
16. Sandén C, Broselid S, Cornmark L, et al. G protein-coupled (MAGUK) scaffold protein, and protein kinase A anchoring
estrogen receptor 1/G protein-coupled receptor 30 localizes protein (AKAP) 5 in MCF7 breast cancer cells. Arch Biochem
in the plasma membrane and traffics intracellularly on Biophys. 2024;752:109882.
Volume 4 Issue 1 (2025) 17 doi: 10.36922/gpd.4632

