Page 48 - GPD-4-1
P. 48
Gene & Protein in Disease GPER1 in brain and heart diseases
46. Hamilton JP. Epigenetics: Principles and practice. Dig Dis. 56. Bai N, Zhang Q, Zhang W, et al. G-protein-coupled estrogen
2011;29(2):130-135. receptor activation upregulates interleukin-1 receptor
antagonist in the hippocampus after global cerebral ischemia:
doi: 10.1159/000323874
implications for neuronal self-defense. J Neuroinflamm.
47. Muhammad A, Hixon JC, Pharmacy Yusuf A, et al. 2020;17(1):45.
Sex-specific epigenetics drive low GPER expression in
gastrointestinal smooth muscles in type 2 diabetic mice. Sci doi: 10.1186/s12974-020-1715-x
Rep. 2024;14(1):5633. 57. Pan MX, Tang JC, Liu R, Feng YG, Wan Q. Effects of
estrogen receptor GPR30 agonist G1 on neuronal apoptosis
doi: 10.1038/s41598-024-54213-7
and microglia polarization in traumatic brain injury rats.
48. Prestegui Martel B, Chávez-Blanco AD, Domínguez- Chin J Traumatol. 2018;21(4):224-228.
Gómez G, et al N-(2-Hydroxyphenyl)-2-propylpentanamide doi: 10.1016/j.cjtee.2018.04.003
(HO-AAVPA) induces apoptosis and cell cycle arrest in
breast cancer cells, decreasing GPER expression. Molecules. 58. Zhang Z, Qin P, Deng Y, et al. The novel estrogenic
2024;29(15):3509. receptor GPR30 alleviates ischemic injury by inhibiting
TLR4-mediated microglial inflammation. J Neuroinflamm.
doi: 10.3390/molecules29153509 2018;15(1):206.
49. Major KM, DeCourten BM, Li J, et al. Early life exposure doi: 10.1186/s12974-018-1246-x
to environmentally relevant levels of endocrine disruptors
drive multigenerational and transgenerational epigenetic 59. Peng J, Yu Z, Xiao R, Hu X, Xia Y. Exosomal ZEB1 derived
changes in a fish model. Front Mar Sci. 2020;7. from neural stem cells reduces inflammation injury in
OGD/R-treated microglia via the GPR30-TLR4-NF-κB axis.
doi: 10.3389/fmars.2020.00471 Neurochem Res. 2023;48(6):1811-1821.
50. Wnuk A, Rzemieniec J, Litwa E, Lasoń W, Kajta M. Prenatal doi: 10.1007/s11064-023-03866-3
exposure to benzophenone-3 (BP-3) induces apoptosis,
disrupts estrogen receptor expression and alters the 60. Wang XS, Yue J, Hu LN, et al. Activation of G protein-coupled
epigenetic status of mouse neurons. J Steroid Biochem Mol receptor 30 protects neurons by regulating autophagy in
Biol. 2018;182:106-118. astrocytes. Glia. 2020;68(1):27-43.
doi: 10.1016/j.jsbmb.2018.04.016 doi: 10.1002/glia.23697
51. Prasanth MI, Sivamaruthi BS, Cheong CSY, et al. Role 61. Yuan LJ, Zhang M, Chen S, Chen WF. Anti-inflammatory
of epigenetic modulation in neurodegenerative diseases: effect of IGF-1 is mediated by IGF-1R cross talk with GPER
Implications of phytochemical interventions. Antioxidants in MPTP/MPP+-induced astrocyte activation. Mol Cell
(Basel). 2024;13(5):606. Endocrinol. 2021;519:l111053.
doi: 10.3390/antiox13050606 doi: 10.1016/j.mce.2020.111053
52. Zhang W, Xiao D, Mao Q, Xia H. Role of neuroinflammation 62. Yin J, Zhang B, Yu Z, et al. Ameliorative effect of dietary
in neurodegeneration development. Signal Transduct Target tryptophan on neurodegeneration and inflammation
Ther. 2023;8(1):267. in d-galactose-induced aging mice with the potential
mechanism relying on AMPK/SIRT1/PGC-1α pathway and
doi: 10.1038/s41392-023-01486-5 gut microbiota. J Agric Food Chem. 2021;69(16):4732-4744.
53. Lebesgue D, Traub M, de Butte-Smith M, et al. Acute doi: 10.1021/acs.jafc.1c00706
administration of non-classical estrogen receptor agonists
attenuates ischemia-induced hippocampal neuron loss in 63. Yin J, Zhang Y, Liu X, et al. Gut microbiota-derived indole
middle-aged female rats. PLoS One. 2010;5(1):e8642. derivatives alleviate neurodegeneration in aging through
activating GPR30/AMPK/SIRT1 pathway. Mol Nutr Food
doi: 10.1371/journal.pone.0008642 Res. 2023;67(9):e2200739.
54. Lebesgue D, Chevaleyre V, Zukin RS, Etgen AM. Estradiol doi: 10.1002/mnfr.202200739
rescues neurons from global ischemia-induced cell death: 64. Peng J, Zuo Y, Huang L, et al. Activation of GPR30 with G1
Multiple cellular pathways of neuroprotection. Steroids. attenuates neuronal apoptosis via src/EGFR/stat3 signaling
2009;74(7):555-561.
pathway after subarachnoid hemorrhage in male rats. Exp
doi: 10.1016/j.steroids.2009.01.003 Neurol. 2019;320:113008.
55. Tang H, Zhang Q, Yang L, et al. GPR30 mediates estrogen doi: 10.1016/j.expneurol.2019.113008
rapid signaling and neuroprotection. Mol Cell Endocrinol. 65. Shen F, Wang J, Gao F, Wang J, Zhu G. Ginsenoside
2014;387(1-2):52-58.
Rg1 prevents cognitive impairment and hippocampal
doi: 10.1016/j.mce.2014.01.024 neuronal apoptosis in experimental vascular dementia
Volume 4 Issue 1 (2025) 19 doi: 10.36922/gpd.4632

