Page 47 - GPD-4-1

Gene & Protein in Disease GPER1 in brain and heart diseases

doi: 10.1016/j.abb.2024.109882 receptor signaling. Hypertension. 2006;47(6):1019-1026.
25. De Francesco EM, Pellegrino M, Santolla MF, et al. GPER doi: 10.1161/01.HYP.0000223064.62762.0b
mediates activation of HIF1α/VEGF signaling by estrogens. 36. Gohar EY. G protein-coupled estrogen receptor 1 as a novel
Cancer Res. 2014;74(15):4053-4064.
regulator of blood pressure. Am J Physiol Renal Physiol.
doi: 10.1158/0008-5472.CAN-13-3590 2020;319(4):F612-F617.
26. Prossnitz ER, Barton M. The G protein-coupled oestrogen doi: 10.1152/ajprenal.00045.2020
receptor GPER in health and disease: An update. Nat Rev 37. Di Mattia RA, Mariángelo JIE, Blanco PG, et al. The
Endocrinol. 2023;19(7):407-424.
activation of the G protein-coupled estrogen receptor
doi: 10.1038/s41574-023-00822-7 (GPER) prevents and regresses cardiac hypertrophy. Life Sci.
2020;242:117211.
27. Weiser MJ, Foradori CD, Handa RJ. Estrogen receptor
beta in the brain: From form to function. Brain Res Rev. doi: 10.1016/j.lfs.2019.117211
2008;57(2):309-320.
38. Deschamps AM, Murphy E. Activation of a novel estrogen
doi: 10.1016/j.brainresrev.2007.05.013 receptor, GPER, is cardioprotective in male and female rats.
Am J Physiol Heart Circ Physiol. 2009;297(5):H1806-H1813.
28. Lu Y, Jiang Q, Yu L, et al. 17β-estradiol rapidly attenuates
P2X3 receptor-mediated peripheral pain signal transduction doi: 10.1152/ajpheart.00283.2009
via ERα and GPR30. Endocrinology. 2013;154(7):2421-2433.
39. Machuki JO, Zhang HY, Geng J, et al. Estrogen regulation
doi: 10.1210/en.2012-2119 of cardiac cAMP-L-type Ca2+ channel pathway modulates
sex differences in basal contraction and responses to β2AR-
29. Takanami K, Sakamoto H, Matsuda KI, et al. Expression of
G protein-coupled receptor 30 in the spinal somatosensory mediated stress in left ventricular apical myocytes. Cell
system. Brain Res. 2010;1310:17-28. Commun Signal. 2019;17(1):34.
doi: 10.1186/s12964-019-0346-2
doi: 10.1016/j.brainres.2009.11.004
40. Ogola BO, Zimmerman MA, Sure VN, et al. G protein-
30. Hazell GGJ, Yao ST, Roper JA, Prossnitz ER, O’Carroll AM,
Lolait SJ. Localisation of GPR30, a novel G protein-coupled coupled estrogen receptor protects from angiotensin
oestrogen receptor, suggests multiple functions in rodent brain II-induced increases in pulse pressure and oxidative stress.
and peripheral tissues. J Endocrinol. 2009;202(2):223-236. Front Endocrinol (Lausanne). 2019;10:586.
doi: 10.3389/fendo.2019.00586
doi: 10.1677/JOE-09-0066
41. Carregosa D, Mota S, Ferreira S, et al. Overview of beneficial
31. Kuhn J, Dina OA, Goswami C, Suckow V, Levine JD,
Hucho T. GPR30 estrogen receptor agonists induce effects of (Poly)phenol metabolites in the context of
mechanical hyperalgesia in the rat. Eur J Neurosci. neurodegenerative diseases on model organisms. Nutrients.
2008;27(7):1700-1709. 2021;13(9):2940.
doi: 10.3390/nu13092940
doi: 10.1111/j.1460-9568.2008.06131.x
42. Brahmachari G. Discovery and Development of
32. Brandt N, Rune GM. Sex-dependency of oestrogen-induced
structural synaptic plasticity: Inhibition of aromatase Neuroprotective Agents from Natural Products. Netherlands:
versus application of estradiol in rodents. Eur J Neurosci. Elsevier; 2018.
2020;52(1):2548-2559. doi: 10.1016/C2014-0-04884-8
doi: 10.1111/ejn.14541 43. Goyal A, Verma A, Agrawal N. Dietary phytoestrogens:
Neuroprotective role in Parkinson’s disease. Curr Neurovasc
33. Prossnitz ER, Barton M. The G-protein-coupled estrogen
receptor GPER in health and disease. Nat Rev Endocrinol. Res. 2021;18(2):254-267.
2011;7(12):715-726. doi: 10.2174/1567202618666210604121233
doi: 10.1038/nrendo.2011.122 44. Cosselman KE, Navas-Acien A, Kaufman JD. Environmental
factors in cardiovascular disease. Nat Rev Cardiol.
34. Wang H, Sun X, Chou J, et al. Cardiomyocyte-specific
deletion of the G protein-coupled estrogen receptor (GPER) 2015;12(11):627-642.
leads to left ventricular dysfunction and adverse remodeling: doi: 10.1038/nrcardio.2015.152
A sex-specific gene profiling analysis. Biochim Biophys Acta 45. Żabińska M, Wiśniewska K, Węgrzyn G, Pierzynowska K.
Mol Basis Dis. 2017;1863(8):1870-1882.
Exploring the physiological role of the G protein-coupled
doi: 10.1016/j.bbadis.2016.10.003 estrogen receptor (GPER) and its associations with human
diseases. Psychoneuroendocrinology. 2024;166:107070.
35. Meyer MR, Haas E, Barton M. Gender differences of
cardiovascular disease: New perspectives for estrogen doi: 10.1016/j.psyneuen.2024.107070

Volume 4 Issue 1 (2025) 18 doi: 10.36922/gpd.4632