Page 54 - GPD-4-1
P. 54
Gene & Protein in Disease GPER1 in brain and heart diseases
170. Xu JJ, Gao P, Wu Y, et al. G protein-coupled estrogen doi: 10.1016/j.psyneuen.2014.12.021
receptor in the rostral ventromedial medulla contributes to 180. Liverman CS, Brown JW, Sandhir R, McCarson KE, Berman
the chronification of postoperative pain. CNS Neurosci Ther. NEJ. Role of the oestrogen receptors GPR30 and ERalpha
2021;27(11):1313-1326. in peripheral sensitization: Relevance to trigeminal pain
doi: 10.1111/cns.13704 disorders in women. Cephalalgia. 2009;29(7):729-741.
171. Zheng W, Huang X, Wang J, et al. The chronification doi: 10.1111/j.1468-2982.2008.01789.x
mechanism of orofacial inflammatory pain: Facilitation by 181. Vermeer LMM, Gregory E, Winter MK, McCarson KE,
GPER1 and microglia in the rostral ventral medulla. Front Berman NEJ. Exposure to bisphenol A exacerbates migraine-
Mol Neurosci. 2022;15:1078309. like behaviors in a multibehavior model of rat migraine.
doi: 10.3389/fnmol.2022.1078309 Toxicol Sci. 2014;137(2):416-427.
172. Xu Z, Xie W, Feng Y, et al. Positive interaction between GPER doi: 10.1093/toxsci/kft245
and β-alanine in the dorsal root ganglion uncovers potential 182. Seehusen F, Baumgärtner W. Axonal pathology and loss
mechanisms: mediating continuous neuronal sensitization precede demyelination and accompany chronic lesions in a
and neuroinflammation responses in neuropathic pain. spontaneously occurring animal model of multiple sclerosis.
J Neuroinflamm. 2022;19(1):164. Brain Pathol. 2010;20(3):551-559.
doi: 10.1186/s12974-022-02524-9 doi: 10.1111/j.1750-3639.2009.00332.x
173. Wang J, Wang S, Fang Z, et al. Estrogen receptor GPR30 in the 183. Kingwell E, Marriott JJ, Jetté N, et al. Incidence and
anterior cingulate cortex mediates exacerbated neuropathic prevalence of multiple sclerosis in Europe: a systematic
pain in ovariectomized mice. Brain Res. 2024;1829:148798. review. BMC Neurol. 2013;13:128.
doi: 10.1016/j.brainres.2024.148798 doi: 10.1186/1471-2377-13-128
174. Xu E, Xia X, Jiang C, et al. GPER1 silencing suppresses the 184. Confavreux C, Hutchinson M, Hours MM, Cortinovis-
proliferation, migration, and invasion of gastric cancer cells Tourniaire P, Moreau T. Rate of pregnancy-related relapse
by inhibiting PI3K/AKT-mediated EMT. Front Cell Dev Biol. in multiple sclerosis. Pregnancy in Multiple Sclerosis Group.
2020;8:591239. N Engl J Med. 1998;339(5):285-291.
doi: 10.3389/fcell.2020.591239 doi: 10.1056/NEJM199807303390501
175. Araldi D, Ferrari LF, Green P, Levine JD. Marked sexual 185. Blasko E, Haskell CA, Leung S, et al. Beneficial role of the
dimorphism in 5-HT1 receptors mediating pronociceptive GPR30 agonist G-1 in an animal model of multiple sclerosis.
effects of sumatriptan. Neuroscience. 2017;344:394-405. J Neuroimmunol. 2009;214(1-2):67-77.
doi: 10.1016/j.neuroscience.2016.12.031 doi: 10.1016/j.jneuroim.2009.06.023
176. Jiang M, Liu Y, Wu H, Ma Z, Gu X. High estrogen level 186. Bodhankar S, Offner H. GPR30 forms an integral part
modifies postoperative hyperalgesia via GPR30 and of e2-protective pathway in experimental autoimmune
MMP-9 in dorsal root ganglia neurons. Neurochem Res. encephalomyelitis. Immunol Endocr Metab Agents Med
2020;45(7):1661-1673. Chem. 2011;11(4):262-274.
doi: 10.1007/s11064-020-03032-z doi: 10.2174/1871522211108040262
177. Felix FB, Vago JP, Fernandes DO, et al. Biochanin a regulates 187. Hirahara Y, Matsuda KI, Yamada H, et al. G protein-coupled
key steps of inflammation resolution in a model of antigen- receptor 30 contributes to improved remyelination after
induced arthritis via GPR30/PKA-dependent mechanism. cuprizone-induced demyelination. Glia. 2013;61(3):420-431.
Front Pharmacol. 2021;12:662308. doi: 10.1002/glia.22445
doi: 10.3389/fphar.2021.662308 188. Wang C, Dehghani B, Li Y, et al. Membrane estrogen receptor
178. Liu H, Duan SR. Prostaglandin E2-mediated upregulation of regulates experimental autoimmune encephalomyelitis
neuroexcitation and persistent tetrodotoxin-resistant Na(+) through up-regulation of programmed death 1. J Immunol.
currents in Ah-type trigeminal ganglion neurons isolated 2009;182(5):3294-3303.
from adult female rats. Neuroscience. 2016;320:194-204. doi: 10.4049/jimmunol.0803205
doi: 10.1016/j.neuroscience.2016.02.008 189. Yates MA, Li Y, Chlebeck PJ, Offner H. GPR30, but not
179. Liu S, Tian Z, Guo Y, Zhang N, Feng B, Zhao M. Activation estrogen receptor-alpha, is crucial in the treatment of
of GPR30 attenuates chronic pain-related anxiety in experimental autoimmune encephalomyelitis by oral ethinyl
ovariectomized mice. Psychoneuroendocrinology. 2015; estradiol. BMC Immunol. 2010;11:20.
53:94-107. doi: 10.1186/1471-2172-11-20
Volume 4 Issue 1 (2025) 25 doi: 10.36922/gpd.4632

