Page 57 - GPD-4-1
P. 57
Gene & Protein in Disease GPER1 in brain and heart diseases
of resveratrol. J Pharmacol Exp Ther. 2008;325(3):961-968. effects in spontaneously hypertensive rat hearts. PLoS One.
2013;8(8):e69322.
doi: 10.1124/jpet.107.135061
doi: 10.1371/journal.pone.0069322
231. Santoro F, Mango F, Mallardi A, et al. Arrhythmic
risk stratification among patients with hypertrophic 241. Kabir ME, Singh H, Lu R, Olde B, Leeb-Lundberg LMF,
cardiomyopathy. J Clin Med. 2023;12(10):3397. Bopassa JC. G Protein-coupled estrogen receptor 1 mediates
acute estrogen-induced cardioprotection via MEK/ERK/
doi: 10.3390/jcm12103397
GSK-3β pathway after ischemia/reperfusion. PLoS One.
232. Fang Z, Raza U, Song J, et al. Systemic aging fuels heart 2015;10(9):e0135988.
failure: Molecular mechanisms and therapeutic avenues.
ESC Heart Fail. 2024. doi: 10.1371/journal.pone.0135988
242. Roubille F, Combes S, Leal-Sanchez J, et al. Myocardial
doi: 10.1002/ehf2.14947
expression of a dominant-negative form of Daxx decreases
233. Kang S, Liu Y, Sun D, et al. Chronic activation of the G infarct size and attenuates apoptosis in an in vivo mouse
protein-coupled receptor 30 with agonist G-1 attenuates model of ischemia/reperfusion injury. Circulation.
heart failure. PLoS One. 2012;7(10):e48185. 2007;116(23):2709-2717.
doi: 10.1371/journal.pone.0048185 doi: 10.1161/CIRCULATIONAHA.107.694844
234. Shao Z, Shen Q, Kong M, Ni H, Hou X. Involvement of 243. Li WL, Xiang W, Ping Y. Activation of novel estrogen
GPR30 in protection effect of Dexmedetomidine against receptor GPER results in inhibition of cardiocyte apoptosis
myocardial ischemia/reperfusion injury in rat via AKT and cardioprotection. Mol Med Rep. 2015;12(2):2425-2430.
pathway. Acta Biochim Pol. 2021;68(1):119-126.
doi: 10.3892/mmr.2015.3674
doi: 10.18388/abp.2020_5473
244. Algoet M, Janssens S, Himmelreich U, et al. Myocardial
235. Pei H, Wang W, Zhao DI, Su H, Su G, Zhao Z. G Protein- ischemia-reperfusion injury and the influence of
coupled estrogen receptor 1 inhibits angiotensin II-induced inflammation. Trends Cardiovasc Med. 2023;33(6):357-366.
cardiomyocyte hypertrophy via the regulation of PI3K-Akt-
mTOR signalling and autophagy. Int J Biol Sci. 2019;15(1):81-92. doi: 10.1016/j.tcm.2022.02.005
245. Wang X, Lu L, Tan Y, et al. GPR 30 reduces myocardial
doi: 10.7150/ijbs.28304
infarct area and fibrosis in female ovariectomized mice by
236. Patten RD, Pourati I, Aronovitz MJ, et al. 17beta-estradiol activating the PI3K/AKT pathway. Life Sci. 2019;226:22-32.
reduces cardiomyocyte apoptosis in vivo and in vitro via
activation of phospho-inositide-3 kinase/Akt signaling. Circ doi: 10.1016/j.lfs.2019.03.049
Res. 2004;95(7):692-699. 246. Krishnan SM, Ling YH, Huuskes BM, et al. Pharmacological
inhibition of the NLRP3 inflammasome reduces blood
doi: 10.1161/01.RES.0000144126.57786.89
pressure, renal damage, and dysfunction in salt-sensitive
237. Lenhart PM, Broselid S, Barrick CJ, Leeb-Lundberg LMF, hypertension. Cardiovasc Res. 2019;115(4):776-787.
Caron KM. G-protein-coupled receptor 30 interacts
with receptor activity-modifying protein 3 and confers doi: 10.1093/cvr/cvy252
sex-dependent cardioprotection. J Mol Endocrinol. 247. van Hout GPJ, Bosch L, Ellenbroek GHJM, et al. The
2013;51(1):191-202. selective NLRP3-inflammasome inhibitor MCC950 reduces
infarct size and preserves cardiac function in a pig model of
doi: 10.1530/JME-13-0021
myocardial infarction. Eur Heart J. 2017;38(11):828-836.
238. Watanabe H, Takahashi E, Kobayashi M, et al. The estrogen-
responsive adrenomedullin and receptor-modifying doi: 10.1093/eurheartj/ehw247
protein 3 gene identified by DNA microarray analysis are 248. Carvalho FS, Burgeiro A, Garcia R, Moreno AJ, Carvalho RA,
directly regulated by estrogen receptor. J Mol Endocrinol. Oliveira PJ. Doxorubicin-induced cardiotoxicity: From
2006;36(1):81-89. bioenergetic failure and cell death to cardiomyopathy. Med
Res Rev. 2014;34(1):106-135.
doi: 10.1677/jme.1.01825
doi: 10.1002/med.21280
239. Barrick CJ, Lenhart PM, Dackor RT, Nagle E, Caron KM.
Loss of receptor activity-modifying protein 3 exacerbates 249. De Francesco EM, Rocca C, Scavello F, et al. Protective
cardiac hypertrophy and transition to heart failure in a sex- role of GPER agonist G-1 on cardiotoxicity induced by
dependent manner. J Mol Cell Cardiol. 2012;52(1):165-174. doxorubicin. J Cell Physiol. 2017;232(7):1640-1649.
doi: 10.1016/j.yjmcc.2011.10.021 doi: 10.1002/jcp.25585
240. De Francesco EM, Angelone T, Pasqua T, Pupo M, 250. Wang H, Sun X, Lin MS, Ferrario CM, van Remmen H,
Cerra MC, Maggiolini M. GPER mediates cardiotropic Groban L. G protein-coupled estrogen receptor (GPER)
Volume 4 Issue 1 (2025) 28 doi: 10.36922/gpd.4632

