Page 61 - GPD-4-1

Gene & Protein in Disease rs670 SNP in APOA1 gene

Figure 1. Flowchart of article searches and selection
Abbreviations: dbSNP: Database of single-nucleotide polymorphisms; GWAS: Genome-wide association study; MAF: Minor allele frequency.

Figure 2. Geographical distribution of articles. Adapted from Wikimedia Commons (https://commons.wikimedia.org/).

[OR] = 1.31; P < 0.001) and lipid parameters such as studies (10.71%) assessed gene-diet interactions. In diets
total cholesterol (TC), low-density lipoprotein cholesterol high in saturated fat, the polymorphic allele was associated
(LDL-c), VLDL-c, HDL-c (OR = 1.34; P = 0.026), triglycerides with elevated TC levels. Conversely, in low-calorie diets
(TG), high-sensitivity C-reactive protein (hsCRP), insulin, rich in polyunsaturated fats, the allele correlated with
and homeostasis model assessment-estimated insulin increased HDL-c levels and reduced LDL-c, insulin, and
resistance (HOMA-IR). In addition, three studies (10.71%) HOMA-IR levels.
found an association between the polymorphic allele and an The remaining studies investigated the association of the
increased risk of ischemic events, such as stroke (OR = 2.28; rs670 polymorphism with other conditions. No significant
P < 0.001) and acute myocardial infarction (relative risk associations were found with neurological diseases, such
[RR] = 2.40; P = 0.034; OR = 1.77; P = 0.042). as schizophrenia and Alzheimer’s, pancreatitis, or benign

Two studies (7.14%) explored the pharmacogenetic breast cancer. However, in malignant breast cancer, the
aspects of the rs670 polymorphism. They found that the homozygous polymorphic genotype was linked to higher
homozygous polymorphic genotype was associated with risks of recurrence (RR = 3.12; P = 0.012) and mortality
improved responses to statins but not to fenofibrate. Three (RR = 4.36; P = 0.006).

Volume 4 Issue 1 (2025) 3 doi: 10.36922/gpd.4354