Page 66 - GPD-4-1
P. 66
Gene & Protein in Disease rs670 SNP in APOA1 gene
Breslow JL. Intracellular and extracellular processing of 13. Block R, Corsetti J, Goldenberg I, et al. The common
human apolipoprotein A-I: Secreted apolipoprotein A-I apolipoprotein A-1 polymorphism −75A>G is associated
isoprotein 2 is a propeptide. Proc Natl Acad Sci U S A. with ethnic differences in recurrent coronary events after
1983;80(9):2574-2578. recovery from an acute myocardial infarction. Heart Int.
2009;4(1):hi.2009.e8.
doi: 10.1073/PNAS.80.9.2574
doi: 10.4081/HI.2009.E8
4. Baldanzi G, Park B, Lee YJ, et al. APOA1/C3/A4/A5 gene
cluster at 11q23.3 and lipid metabolism disorders: From 14. Allot A, Wei CH, Phan L, et al. Tracking genetic variants
epigenetic mechanisms to clinical practices. Biomedicines. in the biomedical literature using LitVar 2.0. Nat Genet.
2024;12(6):1224. 2023;55(6):901-903.
doi: 10.3390/BIOMEDICINES12061224 doi: 10.1038/s41588-023-01414-x
5. Seilhamer JJ, Protter AA, Frossard P, Levy-Wilson B. 15. Ouimet M, Barrett TJ, Fisher EA. HDL and reverse
Isolation and DNA sequence of full-length cDNA and of cholesterol transport: Basic mechanisms and their roles in
the entire gene for human apolipoprotein AI-discovery of vascular health and disease. Circ Res. 2019;124(10):1505.
a new genetic polymorphism in the apo AI Gene. DNA. doi: 10.1161/CIRCRESAHA.119.312617
1984;3(4):309-317.
16. Ruiz-Ramie JJ, Barber JL, Sarzynski MA. Effects of exercise
doi: 10.1089/DNA.1.1984.3.309 on HDL functionality. Curr Opin Lipidol. 2019;30(1):16.
6. Pagani F, Sidoli A, Giudici GA, Barenghi L, Vergani C, Baralle doi: 10.1097/MOL.0000000000000568
FE. Human apolipoprotein A-I gene promoter polymorphism:
Association with hyperalphalipoproteinemia. J Lipid Res. 17. Bhale AS, Venkataraman K. Leveraging knowledge of HDLs
1990;31(8):1371-1377. major protein ApoA1: Structure, function, mutations,
and potential therapeutics. Biomed Pharmacother.
doi: 10.1016/s0022-2275(20)42608-2 2022;154:113634.
7. Smith JD, Brinton EA, Breslow JL. Polymorphism in doi: 10.1016/J.BIOPHA.2022.113634
the human apolipoprotein A-I gene promoter region.
Association of the minor allele with decreased production 18. Kluck GEG, Qian AS, Sakarya EH, Quach H, Deng YD,
Trigatti BL. Apolipoprotein A1 protects against necrotic core
rate in vivo and promoter activity in vitro. J Clin Invest. development in atherosclerotic plaques: PDZK1-dependent
1992;89(6):1796-1800.
high-density lipoprotein suppression of necroptosis in
doi: 10.1172/JCI115783 macrophages. Arterioscler Thromb Vasc Biol. 2023;43(1):45-63.
8. Jeenah M, Kessling A, Miller N, Humphries S. G to A doi: 10.1161/ATVBAHA.122.318062
substitution in the promoter region of the apolipoprotein 19. Tang C, Houston BA, Storey C, Leboeuf RC. Both STAT3
AI gene is associated with elevated serum apolipoprotein AI activation and cholesterol efflux contribute to the anti-
and high density lipoprotein cholesterol concentrations. Mol inflammatory effect of apoA-I/ABCA1 interaction in
Biol Med. 1990;7(3):233-241. macrophages. J Lipid Res. 2016;57(5):848-857.
9. RefSNP Report - dbSNP - NCBI - rs670. Available from: doi: 10.1194/JLR.M065797
https://www.ncbi.nlm.nih.gov/snp/rs670 [Last accessed on
2024 Jul 02]. 20. Wang JL, Gong D, Hu XY, et al. ApoA-1 mimetic peptide
ELK-2A2K2E decreases inflammatory factor levels through
10. Wu Y, Yu Y, Zhao T, et al. Interactions of environmental the ABCA1-JAK2-STAT3-TTP axis in THP-1-derived
factors and APOA1-APOC3-APOA4-APOA5 gene cluster macrophages. J Cardiovasc Pharmacol. 2018;72(1):60-67.
gene polymorphisms with metabolic syndrome. PLoS One.
2016;11(1):e0147946. doi: 10.1097/FJC.0000000000000594
doi: 10.1371/JOURNAL.PONE.0147946 21. Iqbal AJ, Barrett TJ, Taylor L, et al. Acute exposure to
apolipoprotein a1 inhibits macrophage chemotaxis in vitro
11. Yang JM, Park JK, Kim SS, Chun W, Lee HJ. Association and monocyte recruitment in vivo. Elife. 2016;5:e15190.
between apolipoprotein A1 (APOA1) single-nucleotide
polymorphisms and schizophrenia in a Korean population. doi: 10.7554/ELIFE.15190
Clin Psychopharmacol Neurosci. 2010;8(1):45-48. 22. Liu D, Ji L, Zhao M, et al. Lysine glycation of apolipoprotein
A-I impairs its anti-inflammatory function in type 2 diabetes
12. Smach MA, Edziri H, Charfeddine B, et al. Polymorphism in
apoA1 influences high-density lipoprotein cholesterol levels mellitus. J Mol Cell Cardiol. 2018;122:47-57.
but is not a major risk factor of Alzheimer’s disease. Dement doi: 10.1016/J.YJMCC.2018.08.001
Geriatr Cogn Dis Extra. 2011;1(1):249-257.
23. Anantharamaiah GM, Mishra VK, Garber DW, et al.
doi: 10.1159/000329910 Structural requirements for antioxidative and anti-
Volume 4 Issue 1 (2025) 8 doi: 10.36922/gpd.4354

