Page 56 - GPD-4-1
P. 56

Gene & Protein in Disease                                               GPER1 in brain and heart diseases



               coupled estrogen receptor 1 induces coronary artery   continuous-combined oral drospirenone- estradiol on blood
               relaxation via Epac/Rap1-mediated inhibition of RhoA/  pressure, body weight & lipid profile in early menopausal
               Rho  kinase pathway  in  parallel  with  PKA. PLoS One.   women. Indian J Med Res. 2021;154(6):857-865.
               2017;12(3):e0173085.
                                                                  doi: 10.4103/ijmr.IJMR_478_20
               doi: 10.1371/journal.pone.0173085
                                                               221. Delgado  NTB,  Rouver  WN,  Freitas-Lima  LC,  et al.  Sex
            211. Yu X, Stallone JN, Heaps CL, Han G. The activation of G   differences in the vasodilation mediated by G protein-
               protein-coupled estrogen receptor induces relaxation   coupled  estrogen  receptor  (GPER)  in hypertensive rats.
               via cAMP as well as potentiates contraction via EGFR   Front Physiol. 2021;12:659291.
               transactivation in porcine coronary arteries. PLoS One.      doi: 10.3389/fphys.2021.659291
               2018;13(1):e0191418.
                                                               222. Lam CSP, Arnott C, Beale AL, et al. Sex differences in heart
               doi: 10.1371/journal.pone.0191418
                                                                  failure. Eur Heart J. 2019;40(47):3859-3868c.
            212. Bologa CG, Revankar CM, Young SM,  et al. Virtual and      doi: 10.1093/eurheartj/ehz835
               biomolecular screening converge on a selective agonist for
               GPR30. Nat Chem Biol. 2006;2(4):207-212.        223. Iorga A, Li J, Sharma S, et al. Rescue of pressure overload-
                                                                  induced heart failure by estrogen therapy. J Am Heart Assoc.
               doi: 10.1038/nchembio775
                                                                  2016;5:1.
            213. Arefin S, Simoncini T, Wieland R, et al. Vasodilatory effects      doi: 10.1161/JAHA.115.002482
               of the selective GPER agonist G-1 is maximal in arteries of
               postmenopausal women. Maturitas. 2014;78(2):123-130.  224. Recchia AG, de Francesco EM, Vivacqua A,  et al. The G
                                                                  protein-coupled receptor  30 is up-regulated  by hypoxia-
               doi: 10.1016/j.maturitas.2014.04.002
                                                                  inducible factor-1alpha (HIF-1alpha) in breast cancer cells
            214. Feldman RD, Gros R, Ding Q,  et al. A  common    and cardiomyocytes. J Biol Chem. 2011;286(12):10773-10782.
               hypofunctional genetic variant of GPER is associated with      doi: 10.1074/jbc.M110.172247
               increased blood pressure in women. Br J Clin Pharmacol.
               2014;78(6):1441-1452.                           225. Bae S, Lim YH, Lee YA, Shin CH, Oh SY, Hong YC.
                                                                  Maternal urinary bisphenol a concentration during
               doi: 10.1111/bcp.12471
                                                                  midterm pregnancy and children’s blood pressure at age 4.
            215. Fredette NC, Malik E, Mukhtar ML, Prossnitz ER,   Hypertension. 2017;69(2):367-374.
               Terada N. A  hypertension patient-derived iPSC model      doi: 10.1161/HYPERTENSIONAHA.116.08281
               demonstrates a role for G protein-coupled estrogen receptor
               in  hypertension  risk  and  development. Am J Physiol Cell   226. Lombó M, González-Rojo S, Fernández-Díez C, Herráez  MP.
               Physiol. 2020;319(5):C825-C838.                    Cardiogenesis impairment promoted by bisphenol A
                                                                  exposure  is  successfully  counteracted  by  epigallocatechin
               doi: 10.1152/ajpcell.00350.2019
                                                                  gallate. Environ Pollut. 2019;246:1008-1019.
            216. Fredette  NC,  Meyer  MR,  Prossnitz  ER.  Role  of  GPER  in      doi: 10.1016/j.envpol.2019.01.004
               estrogen-dependent nitric oxide formation and vasodilation.
               J Steroid Biochem Mol Biol. 2018;176:65-72.     227.  Morselli E, Santos RS, Criollo A, Nelson MD, Palmer BF, Clegg DJ.
                                                                  The effects of oestrogens and their receptors on cardiometabolic
               doi: 10.1016/j.jsbmb.2017.05.006
                                                                  health. Nat Rev Endocrinol. 2017;13(6):352-364.
            217. Meyer MR, Rosemann T, Barton M, Prossnitz ER. GPER      doi: 10.1038/nrendo.2017.12
               mediates functional endothelial aging in renal  arteries.
               Pharmacology. 2017;100(3-4):188-193.            228.  Feng Z, Wang C, Yue J, Meng Q, Wu J, Sun H. Kaempferol-
                                                                  induced GPER upregulation attenuates atherosclerosis via the
               doi: 10.1159/000478732
                                                                  PI3K/AKT/Nrf2 pathway. Pharm Biol. 2021;59(1):1106-1116.
            218.  Davis GK, Newsome AD, Cole AB, Ojeda NB, Alexander  BT.      doi: 10.1080/13880209.2021.1961823
               Chronic estrogen supplementation  prevents  the increase  in
               blood pressure in female intrauterine growth-restricted offspring   229. Zhao W, Shan X, Li X,  et al. Icariin inhibits hypertrophy
               at 12 months of age. Hypertension. 2019;73(5):1128-1136.  by regulation of GPER1 and CaMKII/HDAC4/MEF2C
                                                                  signaling crosstalk in ovariectomized mice.  Chem Biol
               doi: 10.1161/HYPERTENSIONAHA.118.12379
                                                                  Interact. 2023;384:110728.
            219. Magness RR, Parker CR, Rosenfeld CR. Systemic and      doi: 10.1016/j.cbi.2023.110728
               uterine responses to chronic infusion of estradiol-17 beta.
               Am J Physiol. 1993;265(5 Pt 1):E690-E698.       230. Aubin MC, Lajoie C, Clément R, Gosselin H, Calderone A,
                                                                  Perrault LP. Female rats fed a high-fat diet were associated
               doi: 10.1152/ajpendo.1993.265.5.E690
                                                                  with vascular dysfunction and cardiac fibrosis in the absence
            220. Đogo A, Dožić B, Vujović S, Srebro D, Dožić I. Effects of   of overt obesity and hyperlipidemia: Therapeutic potential


            Volume 4 Issue 1 (2025)                         27                              doi: 10.36922/gpd.4632
   51   52   53   54   55   56   57   58   59   60   61