Page 146 - GPD-4-2

Gene & Protein in Disease BCL11A targets and chromatin binding patterns

dendritic cells activate lymphoid-specific genetic doi: 10.1038/ni925
programs irrespective of their cellular origin. Immunity. 16. Yu Y, Wang J, Khaled W, et al. Bcl11a is essential for
2004;21(1):43-53.
lymphoid development and negatively regulates p53. J Exp
doi: 10.1016/j.immuni.2004.06.011 Med. 2012;209(13):2467-2483.
5. Wang YH, Liu YJ. Mysterious origin of plasmacytoid doi: 10.1084/jem.20121846
dendritic cell precursors. Immunity. 2004;21:1-2.
17. Shi H, Li C, Feng W, et al. BCL11A is oncogenic and predicts
doi: 10.1016/j.immuni.2004.07.003S107476130400175 poor outcomes in natural killer/T-cell lymphoma. Front
Pharmacol. 2020;11:820.
6. Pelayo R, Hirose J, Huang J, et al. Derivation of 2 categories
of plasmacytoid dendritic cells in murine bone marrow. doi: 10.3389/fphar.2020.00820
Blood. 2005;105(11):4407-4415.
18. Seachrist DD, Hannigan MM, Ingles NN, et al. The
doi: 10.1182/blood-2004-07-2529 transcriptional repressor BCL11A promotes breast cancer
metastasis. J Biol Chem. 2020;295(33):11707-11719.
7. Araujo AM, Dekker JD, Garrison K, et al. Lymphoid origin
of intrinsically activated plasmacytoid dendritic cells in doi: 10.1074/jbc.RA120.014018
mice. Elife. 2024;13:RP96394.
19. Borrayo-LóPez FJ, Ibarra-Cortés B, Perea-Díaz F, et al.
doi: 10.7554/eLife.96394 Foetal hemoglobin elevation, unfavorable prognosis, and
protective role of genetic variants HBG2 rs7482144, HBS1L-
8. Ippolito GC, Dekker JD, Wang YH, et al. Dendritic cell
fate is determined by BCL11A. Proc Natl Acad Sci U S A. MYB rs9399137 and BCL11A rs4671393 in children with
2014;111(11):E998-E1006. ALL. J Genet. 2024;103:17.
20. Sunami Y, Yokoyama T, Yoshino S, et al. BCL11A promotes
doi: 10.1073/pnas.1319228111
myeloid leukemogenesis by repressing PU.1 target genes.
9. Feng J, Pucella JN, Jang G, et al. Clonal lineage tracing Blood Adv. 2022;6(6):1827-1843.
reveals shared origin of conventional and plasmacytoid
dendritic cells. Immunity. 2022;55(3):405-422.e11. doi: 10.1182/bloodadvances.2021004558
21. Satterwhite E, Sonoki T, Willis TG, et al. The BCL11 gene
doi: 10.1016/j.immuni.2022.01.016
family: Involvement of BCL11A in lymphoid malignancies.
10. Villani AC, Satija R, Reynolds G, et al. Single-cell RNA-seq Blood. 2001;98(12):3413-3420.
reveals new types of human blood dendritic cells, monocytes,
and progenitors. Science. 2017;356(6335):eaah4573. doi: 10.1182/blood.v98.12.3413
22. Benjamini Y, Hochberg Y. Controlling the false discovery
doi: 10.1126/science.aah4573
rate: A practical and powerful approach to multiple testing.
11. Zhang H, Gregorio JD, Iwahori T, et al. A distinct subset J R Stat Soc Series B (Methodol). 1995;57(1):289-300.
of plasmacytoid dendritic cells induces activation and
differentiation of B and T lymphocytes. Proc Natl Acad Sci doi: 10.1111/j.2517-6161.1995.tb02031.x
U S A. 2017;114(8):1988-1993. 23. Maeda T, Murata K, Fukushima T, et al. A novel plasmacytoid
dendritic cell line, CAL-1, established from a patient
doi: 10.1073/pnas.1610630114
with blastic natural killer cell lymphoma. Int J Hematol.
12. Alcántara-Hernández M, Leylek R, Wagar LE, et al. High- 2005;81(2):148-154.
Dimensional phenotypic mapping of human dendritic cells
reveals interindividual variation and tissue specialization. doi: 10.1532/ijh97.04116
Immunity. 2017;47(6):1037-1050.e6. 24. Adachi N, So S, Iiizumi S, et al. The human pre-B cell line
nalm-6 is highly proficient in gene targeting by homologous
doi: 10.1016/j.immuni.2017.11.001
recombination. DNA Cell Biol. 2006;1:19-24.
13. Matsui T, Connolly JE, Michnevitz M, et al. CD2
distinguishes two subsets of human plasmacytoid dendritic doi: 10.1089/dna.2006.25.19
cells with distinct phenotype and functions. J Immunol. 25. Drexler HG, Minowada J. History and classification of
2009;182(11):6815-6823. human leukemia-lymphoma cell lines. Leuk Lymphoma.
1998;31(3-4):305-316.
doi: 10.4049/jimmunol.0802008
doi: 10.3109/10428199809059223
14. Reizis B. Plasmacytoid dendritic cells: Development,
regulation, and function. Immunity. 2019;50(1):37-50. 26. ENCODE Project Consortium. The Encode (ENCyclopedia
of DNA Elements) Project. Science. 2004;306:636-640.
doi: 10.1016/j.immuni.2018.12.027
doi: 10.1126/science.1105136
15. Liu P, Keller JR, Ortiz M, et al. Bcl11a is essential for normal
lymphoid development. Nat Immunol. 2003;4(6):525-532. 27. Cisse B, Caton ML, Lehner M, et al. Transcription factor

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