Page 53 - GPD-4-2

Gene & Protein in Disease Orexin in depression

for opioid and cannabinoid signalling and pharmacogenetics. doi: 10.1038/nrn3837
Pharmaceuticals (Basel). 2017;10(4):79.
14. Grafe LA, Eacret D, Luz S, et al. Orexin 2 receptor regulation
doi: 10.3390/ph10040079 of the hypothalamic-pituitary-adrenal (HPA) response to
acute and repeated stress. Neuroscience. 2017;348:313-323.
3. Xia L, Liu HY, Wang BY, Lin HN, Wang MC, Ren JX.
A review of physiological functions of orexin: From doi: 10.1016/j.neuroscience.2017.02.038
instinctive responses to subjective cognition. Medicine 15. Grafe LA, Bhatnagar S. Orexins and stress. Front
(Baltimore). 2023;102(26):e34206.
Neuroendocrinol. 2018;51:132-145.
doi: 10.1097/MD.0000000000034206
doi: 10.1016/j.yfrne.2018.06.003
4. Mazur F, Calka J. Hypothalamic orexins as possible 16. Jalewa J, Wong-Lin K, McGinnity TM, Prasad G, Holscher C.
therapeutic agents in threat and spatial memory disorders. Increased number of orexin/hypocretin neurons with high
Front Behav Neurosci. 2023;17:1228056.
and prolonged external stress-induced depression. Behav
doi: 10.3389/fnbeh.2023.1228056 Brain Res. 2014;272:196-204.
5. Kukkonen JP, Jacobson LH, Hoyer D, Rinne MK, Borgland doi: 10.1016/j.bbr.2014.05.030
SL. International union of basic and clinical pharmacology 17. Ji MJ, Zhang XY, Chen Z, Wang JJ, Zhu JN. Orexin prevents
CXIV: Orexin receptor function, nomenclature and depressive-like behavior by promoting stress resilience. Mol
pharmacology. Pharmacol Rev. 2024;76(5):625-688.
Psychiatry. 2019;24(2):282-293.
doi: 10.1124/pharmrev.123.000953
doi: 10.1038/s41380-018-0127-0
6. Peyron C, Kilduff TS. Mapping the hypocretin/orexin 18. Pan YP, Liu C, Liu MF, et al. Involvement of oexin-A in the
neuronal system: An unexpectedly productive journey. regulation of neuronal activity and emotional behaviors in
J Neurosci. 2017;37(9):2268-2272.
central amygdala in rats. Neuropeptides. 2020;80:102019.
doi: 10.1523/JNEUROSCI.1708-16.2016
doi: 10.1016/j.npep.2020.102019
7. Chen Q, de Lecea L, Hu Z, Gao D. The hypocretin/orexin 19. Ji Q, Li SJ, Zhao JB, et al. Genetic and neural mechanisms of
system: An increasingly important role in neuropsychiatry. sleep disorders in children with autism spectrum disorder:
Med Res Rev. 2015;35(1):152-197.
A review. Front Psychiatry. 2023;14:1079683.
doi: 10.1002/med.21326
doi: 10.3389/fpsyt.2023.1079683
8. Johnson PL, Molosh A, Fitz SD, Truitt WA, Shekhar A. 20. Zhang B, Ma S, Rachmin I, et al. Hyperactivation of
Orexin, stress, and anxiety/panic states. Prog Brain Res. sympathetic nerves drives depletion of melanocyte stem
2012;198:133-161.
cells. Nature. 2020;577(7792):676-681.
doi: 10.1016/B978-0-444-59489-1.00009-4
doi: 10.1038/s41586-020-1935-3
9. Sun N, Wei R, Jia B, et al. Bibliometric analysis of orexin: 21. Agirman G, Yu KB, Hsiao EY. Signaling inflammation across
A promising neuropeptide. Medicine (Baltimore). the gut-brain axis. Science. 2021;374(6571):1087-1092.
2024;103(43):e40213.
doi: 10.1126/science.abi6087
doi: 10.1097/md.0000000000040213
22. Kim TK, Han PL. Functional connectivity of basolateral
10. Dinevska M, Widodo SS, Cook L, Stylli SS, Ramsay RG, amygdala neurons carrying orexin receptors and melanin-
Mantamadiotis T. CREB: A multifaceted transcriptional concentrating hormone receptors in regulating sociability and
regulator of neural and immune function in CNS tumors. mood-related behaviors. Exp Neurobiol. 2016;25(6):307-317.
Brain Behav Immun. 2024;116:140-149.
doi: 10.5607/en.2016.25.6.307
doi: 10.1016/j.bbi.2023.12.002
23. Nollet M, Gaillard P, Minier F, Tanti A, Belzung C, Leman
11. Mishima T, Kasanuki K, Koga S, et al. Reduced orexin S. Activation of orexin neurons in dorsomedial/perifornical
immunoreactivity in perry syndrome and multiple system hypothalamus and antidepressant reversal in a rodent model
atrophy. Parkinsonism Relat Disord. 2017;42:85-89.
of depression. Neuropharmacology. 2011;61(1-2):336-346.
doi: 10.1016/j.parkreldis.2017.06.003
doi: 10.1016/j.neuropharm.2011.04.022
12. Chieffi S, Carotenuto M, Monda V, et al. Orexin system: The 24. Zhang XY, Li J, Li CJ, et al. Differential development and
key for a healthy life. Front Physiol. 2017;8:357.
electrophysiological activity in cultured cortical neurons
doi: 10.3389/fphys.2017.00357 from the mouse and cynomolgus monkey. Neural Regen Res.
2021;16(12):2446-2452.
13. Sakurai T. The role of orexin in motivated behaviours. Nat
Rev Neurosci. 2014;15(11):719-731. doi: 10.4103/1673-5374.313056

Volume 4 Issue 2 (2025) 17 doi: 10.36922/gpd.4210