Page 54 - GPD-4-2
P. 54
Gene & Protein in Disease Orexin in depression
25. Parodi G, Zanini G, Collo L, et al. In vitro electrophysiological and plasticity in the hypothalamic hypocretin/orexin
drug testing on neuronal networks derived from human neurons. Neuroscience. 2009;162(4):980-988.
induced pluripotent stem cells. Stem Cell Res Ther. doi: 10.1016/j.neuroscience.2009.05.033
2024;15(1):433.
36. Li Y, Guo Z, Cai C, Liu D, Kang Y, Liu P. The orexinergic
doi: 10.1186/s13287-024-04018-2
system mediates the excitatory effects of caffeine on the
26. Linehan V, Hirasawa M. Electrophysiological properties arousal and sympathetic activity. Heliyon. 2023;9(3):e14170.
of melanin-concentrating hormone and orexin neurons in
adolescent rats. Front Cell Neurosci. 2018;12:70. doi: 10.1016/j.heliyon.2023.e14170
37. Haj-Dahmane S, Shen RY. The wake-promoting peptide
doi: 10.3389/fncel.2018.00070
orexin-B inhibits glutamatergic transmission to dorsal
27. Peleg-Raibstein D, Burdakov D. Do orexin/hypocretin raphe nucleus serotonin neurons through retrograde
neurons signal stress or reward? Peptides. 2021;145:170629. endocannabinoid signaling. J Neurosci. 2005;25(4):896-905.
doi: 10.1016/j.peptides.2021.170629 doi: 10.1523/jneurosci.3258-04.2005
28. Kargar HM, Azizi H, Mirnajafi-Zadeh J, Mani AR, 38. Karnani MM, Venner A, Jensen LT, Fugger L, Burdakov D.
Semnanian S. Orexin a presynaptically decreases inhibitory Direct and indirect control of orexin/hypocretin neurons by
synaptic transmission in rat locus coeruleus neurons. glycine receptors. J Physiol. 2011;589(Pt 3):639-651.
Neurosci Lett. 2018;683:89-93.
doi: 10.1113/jphysiol.2010.198457
doi: 10.1016/j.neulet.2018.06.022
39. Fernandez-Rilo AC, Forte N, Palomba L, et al. Orexin
29. Aou S, Li XL, Li AJ, et al. Orexin-A (Hypocretin-1) induces the production of an endocannabinoid-derived
impairs morris water maze performance and CA1-schaffer lysophosphatidic acid eliciting hypothalamic synaptic loss
collateral long-term potentiation in rats. Neuroscience. in obesity. Mol Metab. 2023;72:101713.
2003;119(4):1221-1228.
doi: 10.1016/j.molmet.2023.101713
doi: 10.1016/s0306-4522(02)00745-5
40. Linehan V, Fang LZ, Hirasawa M. Short-term high-fat diet
30. Bonci A, Borgland S. Role of orexin/hypocretin and primes excitatory synapses for long-term depression in
CRF in the formation of drug-dependent synaptic orexin neurons. J Physiol. 2018;596(2):305-316.
plasticity in the mesolimbic system. Neuropharmacology.
2009;56 Suppl 1:107-111. doi: 10.1113/JP275177
doi: 10.1016/j.neuropharm.2008.07.024 41. Harris T, Bugescu R, Kelly J, et al. DLK1 expressed in mouse
orexin neurons modulates anxio-depressive behavior but
31. Orlando G, Leone S, Ferrante C, et al. Effects of kisspeptin-10 not energy balance. Brain Sci. 2020;10(12):975.
on hypothalamic neuropeptides and neurotransmitters
involved in appetite control. Molecules. 2018;23(12):3071. doi: 10.3390/brainsci10120975
doi: 10.3390/molecules23123071 42. Bilkei-Gorzo A, Albayram O, Ativie F, et al. Cannabinoid
1 receptor signaling on GABAergic neurons
32. Fenzl T, Romanowski CP, Flachskamm C, Deussing influences astrocytes in the ageing brain. PLoS One.
JM, Kimura M. Wake-promoting effects of orexin: Its 2018;13(8):e0202566.
independent actions against the background of an impaired
corticotropine-releasing hormone receptor system. Behav doi: 10.1371/journal.pone.0202566
Brain Res. 2011;222(1):43-50. 43. Aleksandrova LR, Phillips AG, Wang YT. Antidepressant
doi: 10.1016/j.bbr.2011.03.026 effects of ketamine and the roles of AMPA glutamate
receptors and other mechanisms beyond NMDA receptor
33. Kniazkina M, Dyachuk V. Does EGFR signaling mediate antagonism. J Psychiatry Neurosci. 2017;42(4):222-229.
orexin system activity in sleep initiation? Int J Mol Sci.
2023;24(11):9505. doi: 10.1503/jpn.160175
doi: 10.3390/ijms24119505 44. Bénac N, Ezequiel Saraceno G, Butler C, et al. Non-
canonical interplay between glutamatergic NMDA and
34. Alvarez CL, Troncoso MF, Espelt MV. Extracellular ATP and
adenosine in tumor microenvironment: Roles in epithelial- dopamine receptors shapes synaptogenesis. Nat Commun.
mesenchymal transition, cell migration, and invasion. J Cell 2024;15(1):27.
Physiol. 2022;237(1):389-400. doi: 10.1038/s41467-023-44301-z
doi: 10.1002/jcp.30580 45. Bjorness TE, Greene RW. Orexin-mediated motivated
arousal and reward seeking. Peptides. 2024;180:171280.
35. Xia J, Chen F, Ye J, et al. Activity-dependent release of
adenosine inhibits the glutamatergic synaptic transmission doi: 10.1016/j.peptides.2024.171280
Volume 4 Issue 2 (2025) 18 doi: 10.36922/gpd.4210

