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Gene & Protein in Disease                                                          Orexin in depression



               Bull. 2020;36(4):432-448.                          receptor-dependent pathway is implicated in the
               doi: 10.1007/s12264-019-00447-9                    development of overactive bladder and depression in rats
                                                                  exposed to corticosterone. Neurourol Urodyn. 2024.
            109. Esmaili-Shahzade-Ali-Akbari P, Ghaderi A, Sadeghi A,
               Nejat F, Mehramiz A. The role of orexin receptor antagonists      doi: 10.1002/nau.25602
               in inhibiting drug addiction: A review article. Addict Health.   119. Kishi T, Koebis M, Sugawara M, Kawatsu Y, Taninaga T,
               2024;16(2):130-139.                                Iwata N. Orexin receptor antagonists in the treatment of
               doi: 10.34172/ahj.2024.1491                        insomnia associated with psychiatric disorders: A systematic
                                                                  review. Transl Psychiatry. 2024;14(1):374.
            110. Alijanpour S, Khakpai F, Ebrahimi-Ghiri M, Zarrindast MR.
               Co-administration of the low dose of orexin and nitrergic      doi: 10.1038/s41398-024-03087-4
               antagonists  induces  an antidepressant-like  effect in  mice.   120. Na HJ, Jeon N, Staatz CE, Han N, Baek IH. Clinical safety
               Biomed Pharmacother. 2019;109:589-594.             and narcolepsy-like symptoms of dual orexin receptor
               doi: 10.1016/j.biopha.2018.10.033                  antagonists in patients with Insomnia: A systematic review
                                                                  and meta-analysis. Sleep. 2024;47(2):zsad293.
            111. Kron JOJ, Keenan RJ, Hoyer D, Jacobson LH. Orexin receptor
               antagonism: Normalizing sleep architecture in old age and      doi: 10.1093/sleep/zsad293
               disease. Annu Rev Pharmacol Toxicol. 2024;64:359-386.  121. Rocha RB, Bomtempo FF, Nager GB, Cenci GI, Telles
               doi: 10.1146/annurev-pharmtox-040323-031929        JPM. Dual orexin receptor antagonists for the treatment of
                                                                  Insomnia: Systematic review and network meta-analysis.
            112. Brooks S, Jacobs GE, de Boer P, et al. The selective   Arq Neuropsiquiatr. 2023;81(5):475-483.
               orexin-2 receptor antagonist seltorexant improves sleep:
               An exploratory double-blind, placebo controlled, crossover      doi: 10.1055/s-0043-1768667
               study in antidepressant-treated major depressive disorder   122. Zhou M, Tang J, Li S, Li Y, Zhao M. Orexin dual receptor
               patients  with  persistent  Insomnia.  J  Psychopharmacol.   antagonists, zolpidem, zopiclone, eszopiclone, and cognitive
               2019;33(2):202-209.                                research:  A  comprehensive dose-response meta-analysis.
               doi: 10.1177/0269881118822258                      Front Hum Neurosci. 2022;16:1029554.
            113. Staton CD, Yaeger JDW, Khalid D, et al. Orexin 2 receptor      doi: 10.3389/fnhum.2022.1029554
               stimulation enhances resilience, while orexin 2 inhibition   123. Tsuneki H, Wada T, Sasaoka T. Chronopathophysiological
               promotes susceptibility, to social stress, anxiety and
               depression. Neuropharmacology. 2018;143:79-94.     implications of orexin in sleep disturbances and lifestyle-
                                                                  related disorders. Pharmacol Ther. 2018;186:25-44.
               doi: 10.1016/j.neuropharm.2018.09.016
                                                                  doi: 10.1016/j.pharmthera.2017.12.010
            114. Jha MK. Selective orexin receptor antagonists as novel
               augmentation treatments for major depressive disorder:   124. Berger B, Brooks S, Zuiker R, Richard M, Muehlan C,
               Evidence for safety and efficacy from a phase 2B study of   Dingemanse  J.  Pharmacological  interactions  between  the
               seltorexant. Int J Neuropsychopharmacol. 2022;25(1):85-88.  dual orexin receptor antagonist daridorexant and ethanol
                                                                  in a double-blind, randomized, placebo-controlled, double-
               doi: 10.1093/ijnp/pyab078                          dummy, four-way crossover phase I study in healthy
            115. Recourt K, de Boer P, Zuiker R, et al. The selective orexin-2   subjects. CNS Drugs. 2020;34(12):1253-1266.
               antagonist seltorexant (JNJ-42847922/MIN-202) shows      doi: 10.1007/s40263-020-00768-8
               antidepressant and sleep-promoting effects in patients with
               major depressive disorder. Transl Psychiatry. 2019;9(1):216.  125. Xue T, Wu X, Li J,  et al. Different doses of dual orexin
                                                                  receptor antagonists in primary Insomnia: A  Bayesian
               doi: 10.1038/s41398-019-0553-z                     network analysis. Front Pharmacol. 2023;14:1175372.
            116. Brotschi C, Bolli MH, Gatfield J, et al. Pyrazole derivatives as      doi: 10.3389/fphar.2023.1175372
               selective orexin-2 receptor antagonists (2-SORA): Synthesis,
               structure-activity-relationship,  and  sleep-promoting  126. Krause A, Lott D, Brussee JM, Muehlan C, Dingemanse J.
               properties in rats. RSC Med Chem. 2024;15(1):344-354.  Population  pharmacokinetic  modeling  of  daridorexant,  a
                                                                  novel dual orexin receptor antagonist. CPT Pharmacometrics
               doi: 10.1039/d3md00573a                            Syst Pharmacol. 2023;12(1):74-86.
            117. Takaesu Y, Sakurai H, Aoki Y,  et al. Treatment strategy      doi: 10.1002/psp4.12877
               for insomnia disorder: Japanese expert consensus.  Front
               Psychiatry. 2023;14:1168100.                    127. Berger  B,  Kornberger  R, Dingemanse  J. Pharmacokinetic
                                                                  and pharmacodynamic interactions between daridorexant,
               doi: 10.3389/fpsyt.2023.1168100                    a dual orexin receptor antagonist, and citalopram in healthy
            118. Anna S, Jan W, Aleksandra S,  et al. The orexin OX(2)   subjects. Eur Neuropsychopharmacol. 2021;51:90-104.


            Volume 4 Issue 2 (2025)                         22                              doi: 10.36922/gpd.4210
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