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Gene & Protein in Disease NLRP3 in SCI and CHM

indicates that rutin possesses multiple bioactive properties, Availability of data
functioning as an antioxidant, anti-cancer agent, anti-
inflammatory substance, and neuroprotective agent. Not applicable.
105
Moreover, it has been associated with therapeutic benefits References
for conditions such as diabetes, alzheimer’s disease, stroke,
and spinal cord injuries. 106 1. Chen J, Shen Y, Shao X, Wu W. An emerging role of
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50 mg/kg of rutin results in a reduction of NLRP3, IL-1β, evidence-based care, and outcomes in spinal cord injury.
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5. Conclusion
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Taken together, the current evidence suggests that the use
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Acknowledgments
7. Zhu Y, Zhu H, Wang Z, Gao F, Wang J, Zhang W. Wogonoside
None. alleviates inflammation induced by traumatic spinal cord
injury by suppressing NFκB and NLRP3 inflammasome
Funding activation. Exp Ther Med. 2017;14(4):3304-3308.
None. doi: 10.3892/etm.2017.4904

Conflict of interest 8. Schmid-Burgk JL, Chauhan D, Schmidt T, et al. A genome-
wide CRISPR (clustered regularly interspaced short
The authors declare that they have no competing interests. palindromic repeats) screen identifies NEK7 as an essential
component of NLRP3 inflammasome activation. J Biol
Author contributions Chem. 2016;291(1):103-109.
Conceptualization: Ghazaleh Moshkdanian doi: 10.1074/jbc.C115.700492
Writing – original draft: All authors 9. Li Y, Li L, Yu M, Wang Y, Ge HY, Song C. Beneficial effects of
Writing – review & editing: Parvaneh Behi Shahreza the herbal medicine Di Huang Yin Zi in patients with spinal
cord injury: A randomized, placebo-controlled clinical
Ethics approval and consent to participate study. J Int Med Res. 2012;40(5):1715-1724.
Not applicable. doi: 10.1177/030006051204000510

Consent for publication 10. Unterholzner L, Keating SE, Baran M, et al. IFI16 is an
innate immune sensor for intracellular DNA. Nat Immunol.
Not applicable. 2010;11(11):997-1004.

Volume 4 Issue 3 (2025) 6 doi: 10.36922/gpd.4827