Page 81 - GPD-4-3

Gene & Protein in Disease Cullin family members as biomarkers in KIRC

Cullin-ring ubiquitin ligases in kidney health and disease. doi: 10.1158/1078-0432.CCR-04-2225
Curr Opin Nephrol Hypertens. 2019;28(5):490-497.
21. Beroukhim R, Brunet JP, Di Napoli A, et al. Patterns of
doi: 10.1097/MNH.0000000000000527 gene expression and copy-number alterations in von-hippel
lindau disease-associated and sporadic clear cell carcinoma
11. Jiang A, Li J, He Z, et al. Renal cancer: Signaling pathways
and advances in targeted therapies. MedComm (2020). of the kidney. Cancer Res. 2009;69(11):4674-4681.
2024;5(8):e676. doi: 10.1158/0008-5472.CAN-09-0146
doi: 10.1002/mco2.676 22. Cutcliffe C, Kersey D, Huang CC, et al. Clear cell sarcoma of
the kidney: Up-regulation of neural markers with activation
12. Linehan WM, Spellman PT, Ricketts CJ, et al. Comprehensive
molecular characterization of papillary renal-cell carcinoma. of the sonic hedgehog and Akt pathways. Clin Cancer Res.
N Engl J Med. 2016;374(2):135-145. 2005;11(22):7986-7994.
doi: 10.1158/1078-0432.CCR-05-1354
doi: 10.1056/NEJMoa1505917
23. Xu WH, Xu Y, Wang J, et al. Prognostic value and
13. Rhodes DR, Yu J, Shanker K, et al. ONCOMINE: A cancer
microarray database and integrated data-mining platform. immune infiltration of novel signatures in clear cell renal
Neoplasia. 2004;6(1):1-6. cell carcinoma microenvironment. Aging (Albany NY).
2019;11(17):6999-7020.
doi: 10.1016/s1476-5586(04)80047-2
doi: 10.18632/aging.102233
14. Chandrashekar DS, Bashel B, Balasubramanya SAH,
et al. UALCAN: A portal for facilitating tumor subgroup 24. Cheng J, Bin X, Tang Z. Cullin-RING ligase 4 in cancer:
gene expression and survival analyses. Neoplasia. Structure, functions, and mechanisms. Biochim Biophys
2017;19(8):649-658. Acta Rev Cancer. 2024;1879(5):189169.
doi: 10.1016/j.bbcan.2024.189169
doi: 10.1016/j.neo.2017.05.002
25. Berthold J, Schenkova K, Ramos S, et al. Characterization
15. Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA:
A web server for cancer and normal gene expression of RhoBTB-dependent Cul3 ubiquitin ligase complexes-
profiling and interactive analyses. Nucleic Acids Res. -evidence for an autoregulatory mechanism. Exp Cell Res.
2017;45(W1):W98-W102. 2008;314(19):3453-3465.
doi: 10.1016/j.yexcr.2008.09.005
doi: 10.1093/nar/gkx247
26. Lee JW, Chou CL, Knepper MA. Deep sequencing in
16. Warde-Farley D, Donaldson SL, Comes O, et al. The
GeneMANIA prediction server: Biological network microdissected renal tubules identifies nephron segment-
integration for gene prioritization and predicting specific transcriptomes. J Am Soc Nephrol. 2015;26(11):
gene function. Nucleic Acids Res. 2010;38(Web Server 2669-2677.
issue):W214-W220. doi: 10.1681/ASN.2014111067
doi: 10.1093/nar/gkq537 27. Xu M, Yang X, Zhao J, et al. High expression of Cullin1
indicates poor prognosis for NSCLC patients. Pathol Res
17. Zhou Y, Zhou B, Pache L, et al. Metascape provides a
biologist-oriented resource for the analysis of systems-level Pract. 2014;210(7):397-401.
datasets. Nat Commun. 2019;10(1):1523. doi: 10.1016/j.prp.2014.01.015
doi: 10.1038/s41467-019-09234-6 28. Fan YC, Zhu YS, Mei PJ, et al. Cullin1 regulates proliferation,
migration and invasion of glioma cells. Med Oncol.
18. Li T, Fan J, Wang B, et al. TIMER: A web server for
comprehensive analysis of tumor-infiltrating immune cells. 2014;31(10):227.
Cancer Res. 2017;77(21):e108-e110. doi: 10.1007/s12032-014-0227-x
doi: 10.1158/0008-5472.CAN-17-0307 29. Liu W, Wang Y, Zhang C, Huang B, Bai J, Tian L. Cullin1
is up-regulated and associated with poor patients’ survival
19. Yusenko MV, Kuiper RP, Boethe T, Ljungberg B,
van Kessel AG, Kovacs G. High-resolution DNA copy in hepatocellular carcinoma. Int J Clin Exp Pathol.
number and gene expression analyses distinguish 2015;8(4):4001-4007.
chromophobe renal cell carcinomas and renal oncocytomas. 30. Xu J, Fang Y, Wang X, et al. CUL2 overexpression driven
BMC Cancer. 2009;9:152. by CUL2/E2F1/miR-424 regulatory loop promotes
HPV16 E7 induced cervical carcinogenesis. Oncotarget.
doi: 10.1186/1471-2407-9-152
2016;7(21):31520-31533.
20. Jones J, Otu H, Spentzos D, et al. Gene signatures of
progression and metastasis in renal cell cancer. Clin Cancer doi: 10.18632/oncotarget.9127
Res. 2005;11(16):5730-5739. 31. Wang H, Lu Y, Wang M, Wu Y, Wang X, Li Y. Correction to:

Volume 4 Issue 3 (2025) 12 doi: 10.36922/GPD025070014