Page 20 - GTM-2-1
P. 20

Global Translational Medicine                                            Mineralocorticoid receptor in CMD



               mineralocorticoid receptors from macrophages protects   the activation of T helper 17 and the downregulation of
               against deoxycorticosterone/salt-induced cardiac fibrosis   regulatory T lymphocytes. Hypertension, 63: 797–803.
               and increased blood pressure. Hypertension, 54: 537–543.
                                                                  https://doi.org/10.1161/hypertensionaha.113.02883
               https://doi.org/10.1161/hypertensionaha.109.131110
                                                               48.  Bene NC, Alcaide P, Wortis HH,  et al., 2014,
            38.  Bienvenu LA, Morgan J, Rickard AJ, et al., 2012, Macrophage   Mineralocorticoid receptors in immune cells: Emerging role
               mineralocorticoid receptor signaling plays a key role in   in cardiovascular disease. Steroids, 91: 38–45.
               aldosterone-independent cardiac fibrosis.  Endocrinology,      https://doi.org/10.1016/j.steroids.2014.04.005
               153: 3416–3425.
                                                               49.  Kirabo A, Fontana V, de Faria AP, et al., 2014, DC isoketal-
               https://doi.org/10.1210/en.2011-2098
                                                                  modified proteins activate t cells and promote hypertension.
            39.  Olefsky JM, Glass CK, 2010, Macrophages, inflammation,   J Clin Invest, 124: 4642–4656.
               and insulin resistance. Annu Rev Physiol, 72: 219–246.
                                                                  https://doi.org/10.1172/JCI74084
               https://doi.org/10.1146/annurev-physiol-021909-135846
                                                               50.  Araos P, Prado C, Lozano M,  et al., 2019, Dendritic cells
            40.  Guo C, Ricchiuti V, Lian BQ, et al., 2008, Mineralocorticoid   are crucial for cardiovascular remodeling and modulate
               receptor blockade reverses obesity-related changes in   neutrophil  gelatinase-associated  lipocalin  expression
               expression of adiponectin, peroxisome proliferator-activated   upon mineralocorticoid receptor activation.  J  Hypertens,
               receptor-gamma,  and  proinflammatory  adipokines.  37: 1482–1492.
               Circulation, 117: 2253–2261.
                                                                  https://doi.org/10.1097/HJH.0000000000002067
               https://doi.org/10.1161/circulationaha.107.748640
                                                               51.  Buonafine M, Martinez-Martinez E, Amador C,  et al.,
            41.  Wada T, Kenmochi  H, Miyashita Y,  et al., 2010,   2018, Neutrophil gelatinase-associated lipocalin from
               Spironolactone improves glucose and lipid metabolism   immune cells is mandatory for aldosterone-induced
               by ameliorating hepatic steatosis and inflammation and   cardiac remodeling and inflammation. J Mol Cell Cardiol,
               suppressing enhanced gluconeogenesis induced by high-fat   115: 32–38.
               and high-fructose diet. Endocrinology, 151: 2040–2049.
                                                                  https://doi.org/10.1016/j.yjmcc.2017.12.011
               https://doi.org/10.1210/en.2009-0869
                                                               52.  Latouche C, El Moghrabi S, Messaoudi S,  et al., 2012,
            42.  Zhang YY, Li C, Yao GF, et al., 2017, Deletion of macrophage   Neutrophil gelatinase-associated lipocalin is a novel
               mineralocorticoid receptor protects hepatic steatosis   mineralocorticoid target in the cardiovascular system.
               and insulin resistance through ERα/HGF/Met pathway.   Hypertension, 59: 966–972.
               Diabetes, 66: 1535–1547.
                                                                  https://doi.org/10.1161/hypertensionaha.111.187872
               https://doi.org/10.2337/db16-1354
                                                               53.  Guzik TJ, Hoch NE, Brown KA, et al., 2007, Role of the T cell
            43.  Vinh A, Chen W, Blinder Y, et al., 2010, Inhibition and genetic   in the genesis of angiotensin II induced hypertension and
               ablation of the B7/CD28 T-cell costimulation axis prevents   vascular dysfunction. J Exp Med, 204: 2449–2460.
               experimental hypertension. Circulation, 122: 2529–2537.
                                                                  https://doi.org/10.1084/jem.20070657
               https://doi.org/10.1161/circulationaha.109.930446
                                                               54.  Itani HA, McMaster WG Jr., Saleh MA,  et al., 2016,
            44.  Hevia D, Araos P, Prado C, et al., 2018, Myeloid CD11c+   Activation of human T cells in hypertension: Studies of
               antigen-presenting cells ablation prevents hypertension in   humanized mice and hypertensive humans.  Hypertension,
               response to angiotensin II plus high-salt diet. Hypertension,   68: 123–132.
               71: 709–718.
                                                                  https://doi.org/10.1161/hypertensionaha.116.07237
               https://doi.org/10.1161/hypertensionaha.117.10145
                                                               55.  Shen  JZ,  Young  MJ,  2012,  Corticosteroids,  heart  failure,
            45.  Hengel FE, Benitah JP, Wenzel UO, 2022, Mosaic theory   and hypertension: A role for immune cells? Endocrinology,
               revised: Inflammation and salt play central roles in arterial   153: 5692–5700.
               hypertension. Cell Mol Immunol, 19: 561–576.
                                                                  https://doi.org/10.1210/en.2012-1780
               https://doi.org/10.1038/s41423-022-00851-8
                                                               56.  Chu PY, Zatta A, Kiriazis H,  et al., 2011, CXCR4
            46.  Herrada AA, Contreras FJ, Marini NP,  et al., 2010,   antagonism  attenuates  the  cardiorenal  consequences  of
               Aldosterone promotes autoimmune damage by enhancing   mineralocorticoid excess. Circ Heart Fail, 4: 651–658.
               TH17-mediated immunity. J Immunol, 184: 191–202.
                                                                  https://doi.org/10.1161/circheartfailure.110.960831
               https://doi.org/10.4049/jimmunol.0802886
                                                               57.  Li C, Sun XN, Zeng MR,  et al., 2017, Mineralocorticoid
            47.  Amador CA, Barrientos V, Pena J, et al., 2014, Spironolactone   receptor deficiency in T cells attenuates pressure overload-
               decreases doca-salt-induced organ damage by blocking   induced cardiac hypertrophy and dysfunction through


            Volume 2 Issue 1 (2023)                         14                     https://doi.org/10.36922/gtm.v2i1.229
   15   16   17   18   19   20   21   22   23   24   25