Page 19 - GTM-2-1
P. 19
Global Translational Medicine Mineralocorticoid receptor in CMD
https://doi.org/10.1038/nm.1879 https://doi.org/10.1161/hypertensionaha.115.06172
17. Nagase M, Fujita T, 2013, Role of Rac1-mineralocorticoid- 27. Sun XN, Li C, Liu Y, et al., 2017, T-cell mineralocorticoid
receptor signalling in renal and cardiac disease. Nat Rev receptor controls blood pressure by regulating interferon-
Nephrol, 9: 86–98. gamma. Circ Res, 120: 1584–1597.
https://doi.org/10.1038/nrneph.2012.282 https://doi.org/10.1161/circresaha.116.310480
18. Hayashi T, Shibata H, Kurihara I, et al., 2017, High glucose 28. Wu H, Ballantyne CM, 2020, Metabolic inflammation and
stimulates mineralocorticoid receptor transcriptional insulin resistance in obesity. Circ Res, 126: 1549–1564.
activity through the protein kinase C β signaling. Int Heart https://doi.org/10.1161/circresaha.119.315896
J, 58: 794–802.
29. Ferreira NS, Tostes RC, Paradis P, et al., 2021, Aldosterone,
https://doi.org/10.1536/ihj.16-649 inflammation, immune system, and hypertension. Am J
19. Nagase M, Matsui H, Shibata S, et al., 2007, Salt-induced Hypertens, 34: 15–27.
nephropathy in obese spontaneously hypertensive rats via https://doi.org/10.1093/ajh/hpaa137
paradoxical activation of the mineralocorticoid receptor:
Role of oxidative stress. Hypertension, 50: 877–883. 30. Van der Heijden C, Bode M, Riksen NP, et al., 2022, The
role of the mineralocorticoid receptor in immune cells in
https://doi.org/10.1161/hypertensionaha.107.091058 cardiovascular disease. Br J Pharmacol, 179: 3135–3151.
20. Cole TJ, Young MJ, 2017, 30 years of the mineralocorticoid https://doi.org/10.1111/bph.15782
receptor: Mineralocorticoid receptor null mice: Informing
cell-type-specific roles. J Endocrinol, 234: T83–T92. 31. Moore KJ, Tabas I, 2011, Macrophages in the pathogenesis
of atherosclerosis. Cell, 145: 341–355.
https://doi.org/10.1530/joe-17-0155
https://doi.org/10.1016/j.cell.2011.04.005
21. Kolkhof P, Joseph A, Kintscher U, 2021, Nonsteroidal 32. Keidar S, Kaplan M, Pavlotzky E, et al., 2004, Aldosterone
mineralocorticoid receptor antagonism for cardiovascular administration to mice stimulates macrophage nadph
and renal disorders-new perspectives for combination
therapy. Pharmacol Res, 172: 105859. oxidase and increases atherosclerosis development:
A possible role for angiotensin-converting enzyme and the
https://doi.org/10.1016/j.phrs.2021.105859 receptors for angiotensin II and aldosterone. Circulation,
109: 2213–2220.
22. Usher MG, Duan SZ, Ivaschenko CY, et al., 2010,
Myeloid mineralocorticoid receptor controls macrophage https://doi.org/10.1161/01.cir.0000127949.05756.9D
polarization and cardiovascular hypertrophy and 33. Keidar S, Hayek T, Kaplan M, et al., 2003, Effect of eplerenone,
remodeling in mice. J Clin Invest, 120: 3350–3364. a selective aldosterone blocker, on blood pressure, serum
https://doi.org/10.1172/jci41080 and macrophage oxidative stress, and atherosclerosis in
apolipoprotein E-deficient mice. J Cardiovasc Pharmacol,
23. Sun JY, Li C, Shen ZX, et al., 2016, Mineralocorticoid 41: 955–963.
receptor deficiency in macrophages inhibits neointimal
hyperplasia and suppresses macrophage inflammation https://doi.org/10.1097/00005344-200306000-00019
through SGK1-AP1/NF-κBpathways. Arterioscler Thromb 34. Shen ZX, Chen XQ, Sun XN, et al., 2017, Mineralocorticoid
Vasc Biol, 36: 874–885. receptor deficiency in macrophages inhibits atherosclerosis
https://doi.org/10.1161/atvbaha.115.307031 by affecting foam cell formation and efferocytosis. J Biol
Chem, 292: 925–935.
24. McCurley A, Pires PW, Bender SB, et al., 2012, Direct
regulation of blood pressure by smooth muscle cell https://doi.org/10.1074/jbc.M116.739243
mineralocorticoid receptors. Nat Med, 18: 1429–1433. 35. Man JJ, Lu Q, Moss ME, et al., 2021, Myeloid
https://doi.org/10.1038/nm.2891 mineralocorticoid receptor transcriptionally regulates
p-selectin glycoprotein ligand-1 and promotes monocyte
25. Nguyen Dinh A, Griol-Charhbili V, Loufrani L, et al., trafficking and atherosclerosis. Arterioscler Thromb Vasc
2010, The endothelial mineralocorticoid receptor regulates Biol, 41: 2740–2755.
vasoconstrictor tone and blood pressure. FASEB J,
24: 2454–2463. https://doi.org/10.1161/atvbaha.121.316929
https://doi.org/10.1096/fj.09-147926 36. Fraccarollo D, Thomas S, Scholz CJ, et al., 2019, Macrophage
mineralocorticoid receptor is a pleiotropic modulator of
26. Mueller KB, Bender SB, Hong K, et al., 2015, Endothelial myocardial infarct healing. Hypertension, 73: 102–111.
mineralocorticoid receptors differentially contribute
to coronary and mesenteric vascular function without https://doi.org/10.1161/hypertensionaha.118.12162
modulating blood pressure. Hypertension, 66: 988–997. 37. Rickard AJ, Morgan J, Tesch G, et al., 2009, Deletion of
Volume 2 Issue 1 (2023) 13 https://doi.org/10.36922/gtm.v2i1.229

