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Global Translational Medicine Mineralocorticoid receptor in CMD
Acknowledgments Mineralocorticoid receptor antagonists in diabetic kidney
disease-mechanistic and therapeutic effects. Nat Rev Nephrol,
None. 18: 56–70.
Funding https://doi.org/10.1038/s41581-021-00490-8
This work was supported by grants from the National 6. Belden Z, Deiuliis JA, Dobre M, et al., 2017, The role of
Natural Science Foundation of China (81725003, the mineralocorticoid receptor in inflammation: Focus on
kidney and vasculature. Am J Nephrol, 46: 298–314.
82070262, 31900810, 81900227, 82100446), and the
Innovative Research Team of High-Level Local Universities https://doi.org/10.1159/000480652
in Shanghai (SHSMU-ZDCX20212500). 7. Buonafine M, Bonnard B, Jaisser F, 2018, Mineralocorticoid
receptor and cardiovascular disease. Am J Hypertens,
Conflict of interest 31: 1165–1174.
The authors declare that they have no competing interest. https://doi.org/10.1093/ajh/hpy120
Author contributions 8. Rossier BC, 2002, Hormonal regulation of the epithelial
sodium channel enac: N or P(o)? J Gen Physiol, 120: 67–70.
Conceptualization: Jian-Yong Sun, Yong-Li Wang, Hong https://doi.org/10.1085/jgp.20028638
Zhu, Sheng-Zhong Duan
Writing – original draft: Jian-Yong Sun, Yong-Li Wang, 9. Rossier BC, Staub O, Hummler E, 2013, Genetic dissection
Hong Zhu of sodium and potassium transport along the aldosterone-
Writing – review & editing: Jian-Yong Sun, Sheng-Zhong sensitive distal nephron: Importance in the control of blood
pressure and hypertension. FEBS Lett, 587: 1929–1941.
Duan.
https://doi.org/10.1016/j.febslet.2013.05.013
Ethics approval and consent to participate 10. Ivanes F, Susen S, Mouquet F, et al., 2012, Aldosterone,
Not applicable. mortality, and acute ischaemic events in coronary artery
disease patients outside the setting of acute myocardial
Consent for publication infarction or heart failure. Eur Heart J, 33: 191–202.
Not applicable. https://doi.org/10.1093/eurheartj/ehr176
11. Milliez P, Girerd X, Plouin PF, et al., 2005, Evidence for
Availability of data an increased rate of cardiovascular events in patients with
Not applicable. primary aldosteronism. J Am Coll Cardiol, 45: 1243–1248.
https://doi.org/10.1016/j.jacc.2005.01.015
References
12. Funder JW, 2004, Aldosterone, mineralocorticoid receptors
1. Arnett DK, Blumenthal RS, Albert MA, et al., 2019, and vascular inflammation. Mol Cell Endocrinol, 217: 263–269.
2019 ACC/AHA guideline on the primary prevention of
cardiovascular disease: A report of the American college https://doi.org/10.1016/j.mce.2003.10.054
of cardiology/American Heart Association Task Force on 13. Brown NJ, 2008, Aldosterone and vascular inflammation.
clinical practice guidelines. Circulation, 140: e596–e646. Hypertension, 51: 161–167.
https://doi.org/10.1161/CIR.0000000000000678 https://doi.org/10.1161/hypertensionaha.107.095489
2. Sattar N, Gill JM, Alazawi W, 2020, Improving prevention 14. Arriza JL, Weinberger C, Cerelli G, et al., 1987, Cloning of
strategies for cardiometabolic disease. Nat Med, 26: 320–325. human mineralocorticoid receptor complementary DNA:
Structural and functional kinship with the glucocorticoid
https://doi.org/10.1038/s41591-020-0786-7
receptor. Science, 237: 268–275.
3. Bluher M, 2019, Obesity: Global epidemiology and https://doi.org/10.1126/science.3037703
pathogenesis. Nat Rev Endocrinol, 15: 288–298.
15. Barrera-Chimal J, Jaisser F, 2019, Vascular mineralocorticoid
https://doi.org/10.1038/s41574-019-0176-8
receptor activation and disease. Exp Eye Res, 188: 107796.
4. Joseph P, Leong D, McKee M, et al., 2017, Reducing the global https://doi.org/10.1016/j.exer.2019.107796
burden of cardiovascular disease, Part 1: The epidemiology
and risk factors. Circ Res, 121: 677–694. 16. Shibata S, Nagase M, Yoshida S, et al., 2008, Modification
of mineralocorticoid receptor function by Rac1 GTpase:
https://doi.org/10.1161/circresaha.117.308903
Implication in proteinuric kidney disease. Nat Med,
5. Barrera-Chimal J, Lima-Posada I, Bakris GL, et al., 2022, 14: 1370–1376.
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