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Global Translational Medicine Clinical algorithms in ART

proposed by Esteves et al. is a great algorithm that gives Sterilità e MedicinadellaRiproduzione) focused on the
both embryologists and clinicians more information for Key Performance Indicators (KPI) useful for internal
clinical choice orientation (Table 2). The nomograms to and external control of each procedural step of the ART
[27]
predict blastocysts rate following cycles of IVF in patients programs may improve the quality of the entire procedure
with tubal factor infertility, polycystic ovary syndrome, by generating algorithms establishing the gold standards
or endometriosis is another useful algorithm helping procedures as well as their laboratory and clinicians’
[12]
the decision-making of the clinician, embryologist, and coherence . Many other predictive tools are published
couples together to follow-up on the procedure (Table 2). day by day in the literature, such as the natural conception
[9]
[45]
The endometrial receptivity estimation based on the prediction application or an AI model developed to
only parameter of ultrasound and vascularization of predict gestational age more accurately than standard
the endometrium in its own layers is not actually being fetal biometry-based estimates which was achieved by
the factor contributing to the endometrial receptivity utilizing both standard plane ultrasonography images and
[46]
more complex and determined by several independent fly-to ultrasonography videos . Moreover, the progress
parameters rather than this one. However, the establishment in performing studies and AI models are ongoing with an
enthusiastic perspective for patient management.
of each parameter with its own specific score in a database
supporting an algorithm inclusive of all those factors is, 5. Conclusion
from the methodological point of view, the right direction
for future studies . After an impressive increase from 1960 to 2010, the
[34]
world population is decreasing. The total fertility rate is
An algorithm was developed to predict implantation in inverse relationship to the literate couples population
efficiency by taking into account the impact of both female being lower in the high alphabetization communities. The
age and anticipated blastocyst euploidy rates on cumulative use of infertility treatments by IVF is now a worldwide
implantation rates, as published in a hands-on tool, is very phenomenon, with 2%–8% of newborns using this
attractive. Moreover, despite its estimation of implantation technique. The recent use of mathematical models and/
for euploid and aneuploid embryos after transfer according or real-time monitoring algorithms designed to improve
to the age of the women and the number of embryos the diagnostic power of specific tests as well as the best
transferred did not consider the value of the extra embryo management of the treatments is describing a new clinical
[33]
factors, this tool remains of great value for clinicians era where the improvement of efficiency and the reduction
(Table 2). of complications will be the most evident phenomenon.
The prediction of personalized cumulative live birth
following IVF as published by MacLernon et al. and Acknowledgments
[37]
adopted by the Sars registry and American Society for None.
Reproductive Medicine (ASRM) [38] (Table 2) is very helpful
for all involved in the ART programs, from the couples Funding
to the medical doctors. The attempt of other algorithms None.
proposed for the same finality, which include both the
couple’s profiling and the medical center’s performances, Conflict of interest
is a great improvement in medical practice for the
transparency by which the performances are released and The authors declare no conflicts of interest.
for the “True” informed consent to undergo IVF program Author contributions
in one center instead of the other . Public services
[36]
rather than private companies should provide for that. Conceptualization: Francesco Maria Bulletti
Unfortunately, we assist in medical center’s promotion by Data curation: Francesco Maria Bulletti, Marco Berrettini,
media with declared results that are not obtainable. This Romualdo Sciorio, Carlo Bulletti
phenomenon leads to making money on the emotional Formal analysis: Marco Berrettini
fragility of these couples. These AI application models can Writing – original draft: Francesco Maria Bulletti, Carlo
reduce a doubly reprehensible practice on a deontological Bulletti
and human level. Couples seeking information should Writing – review & drafting: Francesco Maria Bulletti,
make it a habit to avoid centers that do not release their Carlo Bulletti
results as disaggregated and verifiable data to national Ethics approval and consent to participate
registries in a transparent manner. The study of the Italian
Group of the SIFES e MR (SocietàItaliana di Fertilità, Not applicable.

Volume 2 Issue 2 (2023) 9 https://doi.org/10.36922/gtm.0308