Page 7 - GTM-2-3

Global Translational Medicine

REVIEW ARTICLE
Inhibiting oxidative stress and inflammation in

acute lung injury using hydrogen: A preclinical
systematic review and meta-analysis

2†
3
1
Guoshen Zhong , Yanhua Shi , Lingyu Kong , Kaixuan Lv , Lichun Zhang ,
1†
1
4
1
1
Mei Yang , Na Tian *, and Nana Yang *
1 School of Life Science and Technology, Weifang Medical University, Weifang, 261053, China
2 Physical Education and Sports School, Soochow University, Suzhou, 215021, China
3 State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine,
Kunming University of Science and Technology, Kunming, 650032, China
4 School of Public Health, Weifang Medical University, Weifang, 261053, China
Abstract
Acute lung injury (ALI) results from excessive inflammation and disruption of the
alveolar-capillary barrier, leading to acute respiratory distress syndrome. Hydrogen,
known as a reducing substance, has been commonly used in preclinical trials of ALI.
The present paper aims to summarize the effects of hydrogen on animal models of
† These authors contributed equally
to this work. ALI and the possible antioxidant and anti-inflammation mechanisms of hydrogen.
*Corresponding authors: We conducted a thorough search of the relevant literature on PubMed, EMBASE,
Na Tian Web of Science, and CNKI. Data retrieved from 20 studies were analyzed to assess
(tina_t123@163.com) the beneficial effects of hydrogen therapy on ALI animal models. To evaluate the
Nana Yang
(benben1980@126.com) effects of hydrogen, commonly assessed outcome indicators include wet-to-dry ratio
(W/D), arterial oxygen partial pressure (PaO ), malondialdehyde (MDA), superoxide
2
Citation: Zhong G, Shi Y, Kong L, dismutase (SOD), and tumor necrosis factor-alpha (TNF-α). The results demonstrate
et al., 2023, Inhibiting oxidative
stress and inflammation in acute that hydrogen reduces pulmonary edema (W/D: 95% CI = −0.98 – −0.85, P < 0.001),
lung injury using hydrogen: mitigates hypoxia (PaO : 95% CI = 6.08 – 22.30, P < 0.001), represses lipid peroxidation
2
A preclinical systematic review and (MDA: 95% CI = −2.12 – −1.06, P < 0.001), scavenges free radicals (SOD: 95%
meta-analysis. Global Transl Med,
2(3): 0379. CI = 10.12 – 30.07, P < 0.001), and inhibits inflammatory response (TNF-α: 95%
https://doi.org/10.36922/gtm.0379 CI = −5.52 – −1.72, P < 0.001). The subgroup analysis showed significant differences
Received: March 30, 2023 between interventions (MDA: P < 0.05; TNF-α: P < 0.05; SOD: P < 0.001). The meta-
regression suggests that species may cause heterogeneity (P < 0.05). These results
Accepted: July 12, 2023
suggest the potential of using hydrogen in clinical trials. Different interventions with
Published Online: August 11, 2023 hydrogen can affect metabolic transport and distribution in vivo. Further studies
Copyright: © 2023 Author(s). should be conducted to validate and confirm these findings.
This is an Open Access article
distributed under the terms of the
Creative Commons Attribution Keywords: Pharmacology; Inflammation; Acute lung injury; Preclinical study; Meta-analysis
License, permitting distribution,
and reproduction in any medium,
provided the original work is
properly cited.
1. Introduction
Publisher’s Note: AccScience
Publishing remains neutral with Acute lung injury (ALI) is an acute pneumonia disease caused by various factors .
[1]
regard to jurisdictional claims in
published maps and institutional Impairment of epithelial and endothelial barrier is a pathology hallmark of ALI, and it
affiliations. can progress into acute respiratory distress syndrome, resulting in diffuse pulmonary

Volume 2 Issue 3 (2023) 1 https://doi.org/10.36922/gtm.0379