Page 11 - GTM-2-3

Global Translational Medicine Hydrogen for acute lung injury

Table 1. Summary of study characteristics
Author Species Type & modeling process Treatment Indicator
Fang et al., 2011 SD rats BI Process: Immersed in boiling water (980C) Hydrogen saline Artery blood: PaO ↑
[21]
2
[English] (Male, 8/8) for 12 seconds (5ml/kg, ip)
Tian et al., 2012 SD rats CLP Process: Use a 4-0 line to ligate the distal Hydrogen saline Lung tissue: W/D↓, SOD↑,
[22]
[Chinese] (Male, 8/8) cecum and then 18G syringe to perforate the (0.6 mmol/L,5 ml/kg, ip) MDA↓, TNF-α↓
ligation of the cecum
Chen et al., 2012 C57BL/6 CLP Process: Ligating the quarter of the 2% H 2 Lung tissue: W/D↓, SOD↑
[23]
[Chinese] (Male, 8/8) proximal cecum (nearby the ileocecal (Nasal inhalation 2 hours)
valve)→perforating ligation at the head and tail
of the cecum→ squeezing out 0.3 ml substances
Li et al., 2014 ICR mice CLP Process: Ligating the quarter of the 2% H Lung tissue: W/D↓
[24]
2
[Chinese] (Male, 6/6) proximal cecum(nearby the ileocecal (Nasal inhalation 2 hours)
valve)→20G syringe to perforate ligation at the
head and tail of the cecum→ squeezing out 0.3
ml substances
[25]
Zhang et al., 2016 C57BL/6 CLP Process: Ligating the half of the distal 2% H Lung tissue: W/D↓ , SOD↑,
2
[Chinese] mice (Male, cecum→ using a 21G syringe to perforate the (Nasal inhalation 2 hours) MDA↓, TNF-α↓
10/10) ligation of the cecum→ using NaCl liquid
(1 ml, IH) for mice recovery
Xie et al., 2010 C57BL/6 CLP Process: Ligating the half of distal cecum→ 2% H Artery blood: PaO -
[26]
2
2
[English] mice (Male, using 21G syringe to perforate the ligation of (Nasal inhalation 2 hours)
30/30) the cecum→ using NaCl liquid (1 ml, IH) for
mice recovery
Bu et al., 2015 SD rats I/R Process: Dividing artery and vein of right 2%H Lung tissue: W/D↓
[27]
2
[Chinese] (Male, 8/8) groin (keeping shocked for 1 hour)→reinfusion (Nasal inhalation 2 hours)
blood (1 hour)
Shi et al., 2013 SD rats I/R Process: Dividing artery and vein of right 2% H Artery blood: PaO ↑ Lung
[28]
2
2
[Chinese] (Male, 8/8) groin (keeping shocked for 1 hour)→reinfusion (Nasal inhalation 10 minutes) tissue: MDA↓, SOD↑, W/
blood (lasting 2 hours) D↓, TNF-α↓
[29]
Zou et al., 2018 Wistar rats I/R Process: Occluding the bilateral femoral Hydrogen saline Artery blood: PaO ↑
2
[English] (Male, 8/8) arteries (lasting 3 hours) and then reinfusion (0.6 mmol/L, 10 ml/kg, ip)
blood (lasting 2 hours)
Liu et al., 2013 Wistar rats LPS Process: LPS from Escherichia coli 055:B5 2% H Lung tissue: PaO ↑, W/D↓ ,
[30]
2
2
[English] (Male, 8/8) (15 mg/kg, ip) (Nasal inhalation 30 minutes) SOD↑, MDA↓, TNF-α↓
Mao et al., 2015 KM mice LPS Process: LPS from Escherichia coli O127:B8 Hydrogen saline Lung tissue: W/D↓
[31]
[Chinese] (Male, 6/6) (20 mg/kg, ip) (15 ml/L, 10 ml/kg, ip)
Xu et al., 2019 SD rats LPS Process: ip, 10 mg/kg Hydrogen saline Lung tissue: W/D↓, SOD↑,
[32]
[Chinese] (Male, 15/15) 2.2 mg/L, 5 ml/kg, ip) MDA↓
Liang et al., 2012 SD rats LPS Process: LPS from Escherichia coli 055:B5 2%H Lung tissue: TNF-α↓
[33]
2
[Chinese] (Male, 8/8) (15 mg/kg, ip) (Nasal inhalation 6 hours)
Song et al., 2016 SD rats LPS Process: LPS from Escherichia coli 055:B5 Hydrogen saline Lung tissue: W/D↓ ,
[34]
[Chinese] (Male, 10/10) (5 mg/kg, ip) (0.6 mmol/l, 10 ml/kg, ip) TNF-α↓
Ying et al., 2017 SD rats OA Process: Caudal vein injection (0.1 ml/kg) Hydrogen saline Artery blood: PaO ↑
[35]
2
[English] (Male, 10/10) (0.4 mg/L, 5 ml/kg, ip)
Ying and He, SD rats OA Process: Caudal vein injection (0.1 ml/kg) Hydrogen saline Artery blood: PaO ↑
2
[36]
2011 [Chinese] (Male, 10/10) (0.4 mg/L, 5 ml/kg, ip) Lung tissue: TNF-α↓
Fang et al., 2012 SD rats PQ Process: Injecting paraquat (35 mg/kg, ip) 2% H Artery blood: PaO2↑
[37]
2
[Chinese] (Male, 8/8) (Nasal lasting 72 hours) Lung tissue: W/D↓, MDA↓
Liu et al., 2015 ICR mice PQ Process: Gavage 20% paraquat (50 mg/kg) Hydrogen saline Lung tissue: MDA↓
[38]
[Chinese] (Male, 8/8) (0.4 mg/L, 5 ml/kg, ip)
Zhang et al., 2011 SD rats PQ Process: Gavage 20% paraquat (50 mg/kg) Hydrogen saline Artery blood: PaO ↑ Lung
[39]
2
[English] (Male, 10/10) (0.4 mg/L, 5 ml/kg, ip) tissue: W/D↓, MDA↓
(Cont’d...)
Volume 2 Issue 3 (2023) 5 https://doi.org/10.36922/gtm.0379